Commercial name Su Ling
Common name Agkistrodon acutus hemagglutinase for injection
English name Haemocoagulase Agkistrodon for injection
Chinese pinyin Zhusheyongjianwenfushexueningmei
The main component is an enzymatic hemostatic agent separated from the venom of Agkistrodon acutus in China.
characteristics this product is a colorless and clear liquid.
Indications: It is used for adjuvant treatment of various bleeding, hemophilia hematoma and thrombocytopenic diseases with hemorrhage. It can also be used for preventive medication before operation, which can reduce bleeding at the operation site and prevent bleeding after operation.
usage and dosage this product can be used for intravenous injection, intramuscular injection and external administration. Prevention of bleeding before operation: intramuscular injection of 1 unit half an hour before operation or intravenous injection of 1 unit 15 minutes before operation. If it is considered that there may be bleeding after operation, 1 unit should be injected intramuscularly 24 hours after operation. Hemorrhage of digestive tract, lung, kidney, cancer, liver disease, etc.: intravenous injection or intramuscular injection of 1 ~ 2 units, and then intramuscular injection of 1 unit every 24 hours until the bleeding stops. Gynecological menorrhagia: intramuscular injection of 1 unit per day, usually for three days.
Pharmacology and toxicology act on fibrinogen, cutting off the fibrin peptide A at the N-terminal of fibrinogen α chain to form unstable fibrin, and fibrin peptide A can constrict blood vessels and promote blood coagulation. This product has a thromboplastin-like effect and can promote the transformation of prothrombin into thrombin; It has the function of improving platelet aggregation, which can make platelets irreversibly aggregate, thus improving platelet function. This product has no effect on promoting platelet aggregation in intact blood vessels.
Pharmacokinetics Clinical pharmacokinetic studies show that the half-life of Suling is about 2.5 hours and there are no metabolites.
Adverse reactions occasionally include urticaria, anxiety, sweating, hypotension and bradycardia.