At present, there are more than 2 types of collagen, among which type I and type III collagen are the main types on our facial skin. Early functional proteins mainly come from animal tissue processing technology. This kind of collagen mainly from fish skin is mostly produced type I collagen, while type III collagen is unique to mammals. Therefore, some scientists extracted it from biological tissues such as pigs and cows, and selected some animals similar to human genome as extraction objects to avoid possible rejection and replenish urgently needed type III collagen. However, this situation still cannot be completely avoided, and it is expensive and has poor water solubility.
However, the humanized collagen developed by Jinbo Bio for ten years has made a leap-forward breakthrough in the acquisition technology. Developed the only humanized type III collagen in the world that is 1% identical to the original sequence of human collagen, obtained the invention patent recognized by the state, and became the only successful industrialization case of collagen included in PDB data in the world. Humanized type III collagen can be widely used in medical care, medical beauty, skin care and other industrial fields because of its standardized raw materials and stable collagen structure, providing diversified application methods for consumption and medical scenes. At present, the functions of humanized type III collagen mainly focus on:
1. Tightening and wrinkle-removing effects: Studies show that with the loss of age, the original coarse type I collagen fibers form wrinkles on the surface skin. Therefore, effectively supplementing humanized type III collagen can form a connective tissue environment under our surface skin, inhibit cell apoptosis, and also repair the original collagen fiber network, so that the original wrinkles can be removed from the surface.
2. moisturizing and whitening effect: jinbo humanized type III collagen contains a large number of hydrophilic amino acids, and it is also the only collagen that has been proved to have the ability to bind water at present. It can achieve powerful water locking and moisturizing effect by using its stable triple helix structure and flexible bending structure of 146.88. Moreover, according to the results of PDB determination, the cell adhesion rate of Jinbo humanized type III collagen is 19% of that of natural collagen, which can activate the metabolic function of cells, reduce the pigmentation of surface skin, avoid the formation of pigmentation and melanin precipitation, and realize the whitening effect.
3. nourishing and anti-aging effect: after using jinbo humanized type III collagen, the SOD activity in skin tissue is significantly increased, and the MMP content in surface skin is effectively reduced, which helps to nourish surface skin and effectively reduce the loss rate of collagen, thus achieving the nourishing and anti-aging effect.
4. Safe repair efficacy: The influence of Jinbo humanized type III collagen on the survival rate of different cell lines is , and its structural sequence is consistent with that of type III collagen synthesized by human body itself, so it will not cause rejection and allergy caused by being attacked by immune system, so it can form collagen network structure more safely, improve the metabolic ability of skin and realize self-repair of skin.
The decade of Jinbo Bio is a decade of vigorous development of functional proteins in China. During this decade, Jinbo Bio, together with Fudan University, Chongqing University and other scientific research institutions, has carried out numerous research and development, from interpreting the structure of collagen to screening functional regions to the final gene recombination and in vitro expression of collagen. Each step seems simple, but countless researchers have devoted a lot of efforts. And the ultimate achievement is bound to be to build an industrialized chain of humanized type III collagen at a world-leading speed, which has injected more powerful development momentum into China's biomedical industry.