Chile, South Africa, Australia, the United States, and Canada have the most outstanding research work on biometallurgy abroad, and were first successfully applied to the industrial development and utilization of copper and uranium. After decades of development, South Africa has begun to use biotechnology to economically recover precious metals from refractory gold concentrates, and most countries have now achieved large-scale industrial application. my country has industrialized the extraction of copper, gold and nickel by microbial oxidation in places such as Dexing Copper Mine in Jiangxi, Zijinshan Copper Mine, Shaanxi Geological Exploration Bureau, Kalatongke in Xinjiang, and Mojiang in Yunnan. At present, biometallurgical technology at home and abroad continues to mature, and its application scope continues to expand. The main application areas include the following aspects: bioheap leaching of secondary copper sulfide ores (chalcocite, covellite, bornite, etc.); primary copper sulfide ores ( Chalcopyrite) bio-heap leaching and bio-stirring leaching of concentrates; bio-leaching of nickel sulfide, cobalt, and zinc ores; bio-metallurgy such as coal desulfurization, bauxite desilication, laterite nickel ore; bio-preoxidation of refractory gold ores.