On January 8, 2019, a research team led by Brazilian scientist Professor Fernanda Felice discovered that a hormone called irisin released from muscles during exercise (swimming) can enter the brain and increase the concentration of iris in the hippocampus of the brain. levels of irisin, thereby rescuing the loss of synaptic plasticity and memory ability caused by AD (Alzheimer's disease). This research has important guiding significance for the prevention and treatment of AD. The relevant paper was published in the famous academic journal "Nature Medicine".
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The invention belongs to the field of medicine and specifically discloses the use of irisin (irisin) in the prevention and treatment of severe acute pancreatitis. In severe acute pancreatitis in mice, intravenous injection of exogenous irisin can significantly improve pancreatic function, reduce endoplasmic reticulum stress in pancreatic cells, and reduce pancreatic tissue damage and cell death, indicating that irisin can significantly improve severe acute pancreatitis. Acute pancreatitis; irisin is used in drug development and injected intravenously when acute pancreatitis is diagnosed in the emergency. When acute pancreatitis is diagnosed, it can block and prevent the local inflammatory reaction from progressing into systemic inflammatory response syndrome or reduce the chain expansion of systemic inflammatory response syndrome. The effect is to inhibit the severity of pancreatitis, protect local organs and prevent the occurrence of multiple organ failure syndrome; the present invention provides a new choice and idea for the current prevention and treatment of severe acute pancreatitis.