What are the most profitable patents in the world so far?

Lipitor. This is a hypolipidemic drug developed by Pfizer at the end of last century. During the patent protection period, the sales exceeded $654.38+000 billion. This sales volume occurred when Lipitor was developed in 1980s, and the patent expired between 2065.438+065.438+0 years. Lipitor patent 20 1 1 expires, which is a major event in the world.