In pharmaceutical industry, microcrystalline cellulose is often used as adsorbent, suspending agent, diluent and disintegrant. Microcrystalline cellulose is widely used in pharmaceutical preparations, mainly as diluent and adhesive for oral tablets and capsules, which can be used for wet granulation and dry direct compression. It also has certain lubricating and disintegrating effects, and is very useful in tablet preparation.
Because there are hydrogen bonds between microcrystalline cellulose molecules, they are associated under pressure, so they are highly compressible and often used as adhesives. After the tablet meets the liquid, the water quickly enters the tablet containing microcrystalline cellulose, and the hydrogen bond breaks immediately, which can be used as a disintegrant. Therefore, it is a widely used auxiliary material in tablet production, which can improve the hardness of tablets. For example, in the preparation of rifampicin tablets, MCC can be mixed with starch (6.25: 1 mass ratio) and various raw materials, and then directly tabletted. The product disintegrates into fog in lm in, and the content remains unchanged during the validity period, which can improve the stability of the drug. For another example, due to the addition of microcrystalline cellulose, the dissolution of prednisone acetate and berberine acetate (sodium bicarbonate) tablets increased to more than 80%. When microcrystalline cellulose is used as an auxiliary material, it does not need to go through the traditional granulation process. For example, MCC was added in the preparation of Kebiqing tablets, which solved the serious sticking phenomenon of Kebiqing wet granulation tablets and disintegrated quickly.
Microcrystalline cellulose can also be used as a sustained-release agent for drugs. The sustained release process is that the active substance enters the porous structure of the carrier, is contained by intermolecular hydrogen bonds, and is fixed after drying. When the active substance is released, due to the diffusion of water in the capillary system of the polymer carrier, the chemical bond between the carrier and the fixed active substance is broken, and the active substance is slowly released.
Microcrystalline cellulose powder can form a stable dispersion system in water, which can be mixed with drugs to make emulsion or suspension liquid medicine, and can also be used as capsules. Microcrystalline cellulose is strongly stirred in water to form gel, which can also be used to prepare paste and suspended pharmaceutical preparations.
American scholars directly pressed paracetamol tablets with excellent physiological effects by fluidized bed agglutination method with microcrystalline cellulose and pregelatinized starch as fillers and disintegrants. British patent points out that microcrystalline cellulose mixed with insoluble drugs can directly extrude spherical pills with gradually released drug effect. According to related literature, microcrystalline cellulose is used to adsorb methyl rosaniline chloride aqueous solution to make ointment, which can prevent fading and antibacterial degradation.
In addition, MCC is also widely used in food industry and cosmetics industry. Microcrystalline cellulose can be used as an important functional food base-dietary fiber in food industry, and it is an ideal health food additive.
In the field of cosmetics, MCC is used as a component of various cosmetics, skin care products and detergents.
The preparation method of microcrystalline cellulose is that α -cellulose can be prepared by controlled hydrolysis with dilute inorganic acid solution, and α -cellulose can be prepared from fiber pulp of cellulose-containing plants. The hydrolyzed cellulose is filtered, purified and spray-dried with water slurry to form dried porous particles with a wide particle size distribution.
Development prospect: In view of its unique structure and performance, microcrystalline cellulose is widely used in the fields of national economy such as medicine and health, food and beverage, light chemical industry, etc. As disintegrant and stable emulsifier. Because cellulose exists widely in nature, hundreds of millions of tons of cellulose-rich biomass residues can be produced worldwide every year. If these residues are well transformed and utilized, they will be a rich resource. The expansion of production scale and the improvement of product grade in domestic tanning, daily chemical, medicine, food and chlor-alkali industries,
The demand for microcrystalline cellulose is increasing year by year, so microcrystalline cellulose has a broad market prospect.
In recent years, in order to continuously improve the performance of microcrystalline cellulose, reduce the production cost and cater to the concept of environmental protection, people have been exploring the preparation of microcrystalline cellulose through cheaper raw materials and more environmentally friendly methods. With the progress of science and technology, the preparation methods of microcrystalline cellulose will be further developed.