Li Ruilin has been engaged in contraceptive research since 196s, and is one of the founders of oral contraceptives in China. He has successfully developed the No.1 contraceptive (norethindrone) and No.53 contraceptive for visiting relatives (diyne decarbonyl ester), which filled the domestic gap and was the first in the world. In 1978, he won the National Science Conference Award. These drugs have become the main varieties of safe, effective, simple and economical contraceptive series with China characteristics, and have made outstanding contributions to the implementation of family planning and the basic national policy in China.
in 198s, anti-early pregnancy drugs received extensive attention at home and abroad. Li Ruilin carefully explored anti-early pregnancy drugs with independent intellectual property rights in China. At that time, after studying abroad, he learned that foreign scientists had developed RU——486, an anti-early pregnancy drug, so he saved his living expenses and bought reagents, and immediately began research work after returning to China. As a result, he found that the yield of foreign synthetic routes was low, the production cost was high, and he needed to import reagents. He led the scientific and technological personnel of the research group to boldly design a scheme to improve the synthetic routes of foreign research based on his years of experience in steroid hormone drugs, and was determined to go his own way. During the "Seventh Five-Year Plan" period, Li Ruilin applied for the national key scientific and technological research project Mifepristone Development Project as the project leader. After numerous explorations and collective efforts, a new synthetic route was finally designed by ourselves, and a new synthetic route of mifepristone with strong specificity, simplified process, high yield and domestic reagent was formed, and the research task of mifepristone was completed. The chemical synthesis route won the national invention patent, and Li Ruilin was the first inventor.
mifepristone, an anti-early pregnancy drug, is the first progesterone antagonist in the world that can selectively block the binding of endogenous progesterone with its receptor, so that fertilized eggs cannot be implanted or early pregnancy cannot be maintained and spontaneous abortion occurs. Sequential combination with low-dose testosterone or other prostaglandins can replace induced abortion, which can make early pregnant women completely abort within 49 days of unwanted pregnancy. It is a safe, effective, convenient and acceptable new method for fertility regulation. Further research also found that mifepristone has great application prospects in oral contraception, menstrual regulation, hormone-dependent disease treatment, certain types of tumor treatment and so on, which is a breakthrough in human fertility regulation and progesterone biology research. The research results of mifepristone, a new anti-early pregnancy drug, have won the second prize of Shanghai Science and Technology Progress Award. Gold medal of the first Shanghai Science and Technology Expo; Second prize of scientific and technological research achievements of the National Family Planning Commission during the Seventh Five-Year Plan; The National Family Planning Commission won the second prize of scientific and technological progress in 1992 and the national second prize of scientific and technological progress in 1993. Li Ruilin also paid attention to the transformation of scientific and technological achievements into production. He and the members of the research group worked closely with Shanghai Hualian Pharmaceutical Company and handed over all the technical keys to the factory without reservation, helping the factory successfully complete the technical transition from pilot test to production in a relatively short time. In November 1992, the drug was approved by the Ministry of Health to be put into production, making China the second country in the world to produce this drug. In 1993, the output value was 7 million yuan and the profit tax was 2 million yuan. In 1993, it was listed as a key project of industrialization of high-tech achievements in Shanghai. It has been widely popularized and applied in the whole country. It has been clinically proved that the complete abortion rate can reach 95%. It is a safe and effective anti-early pregnancy drug with few side effects, which is well received by the masses, creating a precedent for contraceptive production that not only does not lose money, but also produces huge social and direct economic benefits.
The No.1 contraceptive pill and No.53 contraceptive pill studied by Li Ruilin have formed a series of contraceptives with China characteristics. These safe, effective, simple and economical contraceptives are still the main contraceptive drugs in China market. Mifepristone, an anti-early pregnancy drug, has gradually replaced induced abortion to protect pregnant women from the pain and sequelae caused by abortion. In 1993, mifepristone was transferred to Shanghai Hualian Pharmaceutical Co., Ltd., and it has been put into production for many years, with an annual output value of over 1 million yuan. During the Ninth Five-Year Plan period, Li Ruilin organized the development of compound anti-early pregnancy drugs, a key scientific and technological project of the National Ninth Five-Year Plan, in order to solve the problems of long bleeding time and high cost of mifepristone abortion. The drug research has applied for a patent and is under review. Compound mifepristone tablets are composed of two kinds of compound preparations, which are used to stop early pregnancy within 49 days after menopause. Animal experiments have proved that the combination of the two drugs has obvious synergistic effect after statistical treatment. Approved by National Medical Products Administration in 1999XL9 for clinical research of new drugs, the third phase of clinical research has been completed. The clinical study adopts a randomized, double-blind, double-simulated 2: 1 control method. The observation results show that the abortion effect, fetal sac discharge, bleeding, menstrual recovery and adverse reactions of the experimental group are similar to those of the control group. The compound mifepristone tablet has the same curative effect as the single mifepristone tablet when the dosage of mifepristone is reduced by 6%. Therefore, the compound mifepristone tablet has the advantages of liver function damage and glucocorticoid side effects caused by reducing the dosage of mifepristone, and it is also easier to take medicine. The development of the drug is being submitted for approval for new drug certificate and production approval, which will have great social and economic benefits once it is listed.
Li Ruilin has been engaged in the research of contraceptive drugs for a long time. He is not afraid of difficulties and has the courage to explore. When he went deep into the factory to guide the scale-up trial production, the reaction bottle suddenly exploded, and glass fragments were embedded in his eyes. After rescue, his left eye was completely blind and his right eye vision was .1. He didn't retreat, but devoted himself to the research of new contraceptive drugs. Although Li Ruilin is sickly and over sixty years old, he still persists in working tirelessly in the front line of scientific experiments all the year round, and continues to play a role in the development of reproductive health care drugs in China, selflessly dedicating his wisdom and strength. Recently, Li Ruilin continued to innovate in his research work, and applied for two China patents, namely, Compound with Efficacy for Treating Prostatic Hyperplasia and its Preparation Method and Compound with Antifertility Effect and its Preparation Method, making new contributions to the development of reproductive health care technology.
Li Ruilin kept innovating in his research work, and applied for two China patents, namely, Compound with Efficacy for Treating Prostatic Hyperplasia and its Preparation Method and Compound with Antifertility Effect and its Preparation Method, which made new contributions to the development of reproductive health care technology.
At the same time, the new anticancer drug "AC-7619" was discovered, and it was clinically tried in more than 2, cases, with remarkable curative effect, and obtained the American invention patent. In 1996, it was developed into a compound anti-early pregnancy drug and was patented in China. In 1998, it was discovered that the anti-prostate altar was innovative. In 22, it was patented in China. In 21, it was discovered that a simple oral contraceptive pill only needed to be taken once a month. In 23, it was patented in China. In 1996, he was elected as an academician of China Academy of Engineering.
﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣ ﹣. 198-Coach Award of Zhongzheng Cup Junior League Championship. 1989-took over as the head coach of Luguang baseball team and won the first group spring league championship for two consecutive years. 199-Won the title of "Triple Crown" for the first time. In that year, Lu Guang won the championship in the Spring League, followed by Meihe Youth League and Youth League. 1991-Joined the Times Eagle (Amateur) as the head coach, and immediately led the Hawks to win the autumn league championship for two consecutive years. 1997-In the first half of the eight-year baseball season of China Professional Baseball, he led the Times Eagle to win the first championship in the team's history. From 2 to March 7, he died of nasopharyngeal carcinoma. From March 5, 25 to March 5, 25, "Li Ruilin Memorial Tournament" was held at Tianmu Baseball Stadium. More than 8, fans braved the cold current and remembered the so-called Teacher Li with the Hawks players who had not gathered for many years.
in p>21, his widow, Li Shumei, was invited to present an award to Zhang Taishan, a soldier who won the hit king. When Zhang Taishan received the award, she said, "When I was a student, Mr. Li taught many very famous players now, and now he coached us by Chen Ruizhen, the head coach of the Brothers Elephant Team, and Peng Zhengmin, our batting king, and then I saw Jenny standing here. When his students get this award, it is for Mr. Li and General Manager Li, and it is for him. Although he can't stand in this place and get what he wants, I believe he must hope to see his students stand on the stage and become an outstanding player. 」