The 1 1β- hydroxylation of steroids is considered to be one of the most important reactions before the biotransformation of many steroids. t [k] is used to obtain glucocorticoids with antipyretic and antiallergic effects on an industrial scale, such as hydrocortisone, prednisolone and fluorinated corticosteroids (triamcinolone acetonide, dexamethasone, etc.) [1].
The maximum method of 1 1β- hydroxylation of δ4-3- steroids is to obtain hydrocortisone ([S]2 1[O] 5[N]30, hydrocortisone, Kendall substance "f" and [pregn]-4- ene. 20- Method Hydrocortisone is an independent preparation used to treat arthritis, bursitis, skin inflammation, allergic diseases and other diseases, so it is also the initial matrix before synthesizing other corticosteroids (corticosterone, prednisolone, prednisone, [methylprednisolone]) [2]. Another 1 1β- hydroxylation is necessary to obtain dexamethasone by 16α-[metilkorteksolon] according to the diagram.
Because of their high physiological activity and another11β-[gidroksiproizvodnye] .delta.4-3-[ketosteroids] [22-28], they also show interest as linkages. 11β-[gidrokssisteroy] is obtained by introducing 1 1- hydroxyl group beside steroid molecules with the help of microorganisms-the lowest fungi. However, contrary to 1 1α- hydroxylation, it has realized more than 300 forms of microorganisms and has the ability to accumulate a satisfactory yield of11β-[gidrokssisteroidov]. But before mixing, for11α-[gidroksiproduktami], It is inherently before a limited number of fungal forms-Clonorchis, Klebsiella Blakeslee and only 35 known forms of Curvularia fungal strains (collections-[ATSS], IFO, NRRL, BKM and others) were widely distributed before nature, mainly at 1 1β-. The advantages of [s] form. Lunata can also hydroxylate 2 1-[gidrokssisteroidov] and 21-[metilsoderzhashchikh] steroids 1 1β- [2,3,27].
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