When NMR was sent, the sample was soluble in dmso and methanol. Which deuterated reagent should I choose?
I've never been a very complicated molecule. According to my personal feeling, I basically started with deuterium chloride in Xian Yi, and I can't make any further changes, regardless of age. Solubility is an important factor. If the solubility of deuterium chloride is not good enough, deuterium DMSO, deuterium methanol, deuterium acetic acid, deuterium trifluoroacetic acid and deuterium water with stronger polarity can be used. . . Deuterium chloride is weakly acidic. If there is a key active hydrogen in the molecule to be observed, deuterated DMSO should be used instead; . If the molecule is sensitive to acid, add less alkali to deuterium chloride for neutralization; If the solvent peak position coincides with a key peak position, it must be replaced.