Stem cell research was carried out earlier in China, especially in the field of amniotic stem cell research for more than ten years. It is proved that amniotic epithelial cells not only have the characteristics of embryonic stem cells, but also are the best neural precursor cells besides neural stem cells, and have immeasurable prospects in the clinical treatment of neurodegenerative diseases and nerve injury diseases. Studies have proved that amniotic epithelial cells can be used as stem cells not only to treat diseases that need to be repaired, but also to treat inflammation, tissue fibrosis, allergic diseases and autoimmune diseases, including preventing graft-versus-host disease (GVHD) and enhancing the immune tolerance of grafts. This research has published more than 30 research papers, applied for 5 invention patents at home and abroad, and granted 2 patents. At present, the research is advancing to the clinical direction, and clinical trials have been carried out in cooperation with hospitals, which have achieved remarkable results in the treatment of some diseases.
Study on Industrialization of Recombinant Human Growth Hormone
65438-0985 presided over the national key scientific and technological project "Growth Hormone Genetic Engineering" and led the project team of "Human Growth Hormone Genetic Engineering" to complete the whole process from laboratory research to rhGH industrialization. The research achievement of recombinant human growth hormone (rhGH) in the laboratory stage of genetic engineering won the second prize of scientific and technological progress of China Academy of Sciences; The pilot process of 80-liter fermentor passed the acceptance organized by Shanghai Science and Technology Commission and Shanghai Economic Commission, and the recombinant human growth hormone (rhGH) obtained the new drug certificate from the Ministry of Health, with completely independent intellectual property rights. Subsequently, we continued to study the new dosage form and formula of rhGH, and achieved good results in the fields of treating children's pituitary dwarfism, anti-aging, skin care and beauty, and applied for and obtained the invention patent authorization.
Artificial total synthesis of yeast alanine tRNA
As one of the initiators, organizers and leaders of this work, this research achievement has won the first prize of the National Natural Science Award, Chen Jiageng and other awards. .
A plasmid bidirectional DNA sequencing method was established.
Any DNA sequence cloned from multiple cloning sites can be determined in two directions, which laid the foundation for later DNA automatic sequencer and "genome project research" and promoted the development of life science.
The earliest research on transgenic animals in China (1985).
The research of transgenic rabbits is carried out under the national key scientific research project "Individual Expression System". This research achievement won the first prize of 1990 China Academy of Sciences for scientific and technological progress.
Heterogeneous organ transplantation and transplantation immunity
It is listed as a major basic theoretical research project of the National Natural Science Foundation and the "863 Project" of the Ministry of Science and Technology, and has published more than ten SCI papers.
Study on transgenic mice with human antibody
With the support of key projects of Chinese Academy of Sciences and Shanghai Science and Technology Commission, the research work of chromosome targeting, construction of human chromosome bank, synthesis of human immunoglobulin light chain chromosome fragments and construction of chimeric mice has been completed, which makes technical preparations for the final completion of "human antibody transgenic mice".
The research field of neurotransmitter transporters has a certain influence in the world.
This research work started earlier in the world, and comprehensively and systematically studied the transporters of various neurotransmitters, published more than 40 SCI papers and applied for more than 10 patents at home and abroad.