Acute oral LD50； in rats; 5000 mg/kg, acute percutaneous LD50 of rats >: 2000 mg/kg; No irritation to rabbit eyes, mild irritation to rabbit skin and no allergy to guinea pig skin. The maximum ineffective dose of the original drug in the 90-day subchronic feeding test of rats was 507mg/kgd for males and 549,507 mg/kgd for females. Ames test and micronucleus test of mouse bone marrow cells were negative, and no mutagenicity was found.
Effects of tribenuron-methyl sodium salt on rainbow trout LC50 (96h) >:103mg/l; The acute oral LD50 of mallard duck was more than 2250 mg/kg; The LC50 (96h) of silkworm is more than 3750mg/kg, and the original drug is low toxic to fish, birds, bees and silkworms.