Omicron epidemic has occurred in many parts of the country. In the competition with COVID-19, more domestic small molecule oral drugs are put into research and development. Most of the action mechanism of COVID-19 small molecule oral drugs is to kill the virus by interfering with its self-replication. Because it mainly acts on cells, the intracellular process is relatively conservative and not easy to mutate, so the effect is not easy to be influenced by mutant strains. In addition, convenient administration, easy production, storage and transportation are also a major advantage of these drugs.
In the clinical trials carried out in China, at present, the domestic small molecule drugs produced in COVID-19 have the fastest growth rate: alfudine from real organism, clomipramine from 09939.HK Kaituo Pharmaceutical and VV 1 16 from Junshi Bio. These three drugs are RdRp inhibitors, AR antagonists and RdRp inhibitors. In April this year, Real Bio said that it was making every effort to promote the listing of azvudine for the treatment of COVID-19. But up to now, there is no further listing progress report.
Junshi Bio said that according to the requirements of relevant laws and regulations on drug registration in China, drugs need to complete clinical research and pass the review of the US Food and Drug Administration before they can be produced and listed. The company communicates with the drug regulatory authorities and submits the application for listing new drugs. NCT0534 1609 is a multi-center, single-blind, randomized controlled phase I clinical study initiated by Junshi Bio, aiming at evaluating the efficacy and safety of VV 1 16 and paciclovir in the early treatment of patients with mild to moderate COVID-19.
Everyone has a different opinion. Everyone knows that the COVID-19 epidemic has brought great influence on our lives, so everyone should pay attention to these problems in life and try to change themselves. If you want to be better, you should be prepared in advance at this time. So there is no need for everyone to feel too nervous. If oral drugs can be successfully marketed, there is no need to vaccinate everyone. Many people will feel that vaccination is very painful, and many people will have side effects, so the probability of vaccination will greatly increase.