Heilongjiang Provincial Government Pricing Drug Price Publicity Form
165 gulisen protein hydrolysate tablets 12 tablets/box 49.6 yuan.
166 gulixi cerebroprotein hydrolysate tablets 24 tablets/box 88.3 yuan.
Generic name: Gulixi Brain Protein Hydrolysate Tablets
Original name: brain enzyme hydrolysis tablets
Chinese name: cerebrolysin tablets
The components of cerebroprotein hydrolysate tablets contain amino nitrogen and total nitrogen.
This product is a sugar-coated tablet with a brownish yellow core.
Pharmacological Action This product can easily enter brain cells and neurons through the blood-brain barrier, activate adenylate cyclase, promote protein synthesis of brain cells, directly participate in controlling and regulating protein metabolism of brain tissue cells, enhance succinate dehydrogenase activity of brain cells, and improve symptoms such as brain hypoxia, memory reproduction disorder and brain decline. Conducive to the repair of nervous system cells, can be used to treat a variety of nervous system diseases, and has an auxiliary therapeutic effect on anti-aging of middle-aged and elderly people.
Indications can be used to improve symptoms such as insomnia, headache, dizziness and irritability, and can promote the recovery of acute cerebral infarction and acute brain injury. It can also be used for sequelae of brain trauma, cerebrovascular diseases, encephalitis sequela's diseases and neurosis, cerebral blood supply insufficiency, cerebral hypoplasia, senile dementia and memory loss related to various sequelae.
Usage and dosage: Take orally, 3 times a day, 2-4 tablets for adults each time, and reduce the dosage for children or follow the doctor's advice.
Adverse reactions: no adverse reactions such as liver, kidney and nervous system;
Taboo is not clear.
Caution: Use with caution for allergic people.
Pregnant women and lactating women are forbidden to take drugs.
When drug interaction and antidepressants are taken at the same time, it is suggested to reduce the dose of antidepressants.
Gauge 6.5mg (based on amino acid): 14.4mg (based on total nitrogen)
24 tablets per box
Storage is sealed and kept in a cool and dry place.
Valid for two years.
Approval number: National Medicine Zhunzi H23023288
Name of manufacturer: Heilongjiang Jiangshi Pharmaceutical Co., Ltd.
Address: No.2 Weihai Road, Fangping Economic and Technological Development Zone, Harbin
Postal code: 150069
Telephone number: 045 1-6546840
Fax number: 045 1-6547704
Two. sulpiride
Drug name
Common name: sulpiride tablets.
English name: Sulpiride tablets
Chinese Pinyin: Chinese Pinyin
The main component of this product is sulpiride, and its chemical name is N-[ methyl -( 1- ethyl -2- pyrrolidinyl) ]-2- methoxy -5- aminosulfonyl)-benzamide.
Molecular formula: C 15H23N3O4S.
Molecular weight: 34 1.42
Character; Role; letter
This product is a white tablet.
Pharmacology and toxicology
This product belongs to benzamide antipsychotic drugs, and its function is characterized by selectively blocking dopamine (DA2) receptor in the midbrain limbic system, which has little influence on other transmitter receptors, light anticholinergic effect, no obvious sedative and anti-agitation effects, and strong antiemetic and gastric juice secretion inhibition effects.
pharmacokinetics
This product is absorbed by gastrointestinal tract, and the blood concentration can reach the peak within 2 hours. After 48 hours of oral administration, 30% of the oral dose is excreted from urine and some from feces. The half-life of plasma is 8 ~ 9 hours. Animal experiments show that this product can enter the cord blood circulation through the placental barrier. This product is mainly excreted by the kidney. Can be excreted from breast milk.
indicate
It has good curative effect on symptoms such as indifference, withdrawal, stupor, depression, hallucination and delusion, and is suitable for symptoms such as loneliness, withdrawal and indifference of simple schizophrenia, paranoid schizophrenia, catatonic schizophrenia and chronic schizophrenia. It has certain curative effect on depressive symptoms. Other uses are anti-vomiting.
dosage
Oral treatment of schizophrenia, the initial dose is 100mg( 1 tablet) 1 time, 2 ~ 3 times a day, the therapeutic dose is gradually increased to 600 ~ 1200 mg (6 ~ 12 tablets) a day, and the maintenance dose is 2000. To stop vomiting, 100 ~ 200mg once (1 ~ 2 tablets), 2 ~ 3 times a day.
counteraction
1, common insomnia, early awakening, headache, irritability, fatigue, loss of appetite, etc. There may be dry mouth, blurred vision, tachycardia, dysuria, constipation and other anticholinergic adverse reactions.
2. When the dose is greater than 600 mg per day, extrapyramidal reactions may occur, such as tremor, rigidity, salivation, bradykinesia, akathisia and acute dystonia.
3. The concentration of prolactin in plasma increases, and the possible symptoms include galactorrhea, feminization of male breasts, menstrual disorder, amenorrhea and weight gain.
4. Abnormal electrocardiogram and liver function damage may occur.
5. A few patients may have excitement, excitement, sleep disorder or elevated blood pressure.
6. Long-term and large-scale drug use will lead to tardive dyskinesia.
taboo
Pheochromocytoma, patients with hypertension, patients with severe cardiovascular diseases and severe liver diseases, and those who are allergic to this product are prohibited.
Matters needing attention
1, used with caution for patients with cardiovascular diseases (such as arrhythmia, myocardial infarction and abnormal conduction).
2. In the case of tardive dyskinesia, all antipsychotics should be stopped.
3. Patients with allergic skin rash and malignant symptoms should immediately stop taking drugs and deal with them accordingly.
4, basal ganglia disease, Parkinson's syndrome, severe central nervous system inhibition with caution.
5, liver and kidney dysfunction should be reduced.
6, epilepsy patients with caution.
Medication for pregnant and lactating women
Pregnant women should use it with caution and reduce the dosage when using it. Lactating women should stop breastfeeding during the use of this product.
Children's medication
Children over 6 years old should start with a small dose and gradually increase the dose according to the adult dose.
Medication for elderly patients
Elderly patients should start with a small dose and gradually increase the dose.
drug interaction
Except clozapine, almost all antipsychotics and central depressants interact with clozapine, which should be paid full attention to.
excessive
Poisoning symptoms:
1. Central nervous system symptoms: serious disturbance of consciousness, from drowsiness and inattention to lethargy, and finally into coma. During the examination, it can be found that the pupils are narrowed and slow to respond to light. At the same time accompanied by central hypothermia.
2. Symptoms of cardiovascular system: postural hypotension, increased heart rate, accelerated pulse, occasional arrhythmia, and even hypovolemic shock in severe cases.
3, blood system symptoms: neutropenia, allergic purpura.
Treatment: gastric lavage, catharsis and infusion. According to the condition, symptomatic treatment and supportive therapy were given.
Meter 100 mg
Storage and shading, sealed preservation.
Packed in plastic bottles, each containing 100 tablets.
Valid for 3 years.
The approval number is National Medicine Zhunzi H32023 126.
Production enterprise
Enterprise name: Jiangsu Tasly First Pharmaceutical Co., Ltd.
Production address: No.29, Chengnan West Road, Qingpu District, Huai 'an, Jiangsu Province.
Postal code: 223002 Tel: 05 17-3803898 Fax: 05 17-3803898
3.Xi Pumiao
Indications: Routine treatment of depressive mental disorder (endogenous and endogenous depression), depression and anxiety.
[Usage and Dosage] Take orally, the initial dose is 20mg, qd, which can be increased to 40mg, qd if necessary, and the maximum dose can be increased to 60mg, qd, once in the morning and once in the evening. The appropriate dose for patients with hepatic insufficiency is 20mg dˉ 1, and it can be increased to 40mg dˉl if there is no adverse reaction. The dose for people over 65 years old is halved, namely 10 ~ 30 mg, qd.
Antidepressant treatment belongs to symptomatic treatment and must last for a period of time. General manic-depressive mental disorder takes 4 to 6 months. If insomnia or severe akathisia occurs, it is suggested to supplement sedation treatment in acute attack.
[Adverse drug reactions] Common adverse reactions include nausea, dry mouth, lethargy, increased sweating, headache and short sleep time, which are usually more obvious in the first 1 and second weeks of treatment; With the improvement of depression, the adverse reactions gradually disappeared. There are also seizures. This product can cause hormone secretion disorder, mania, tachycardia and postural hypotension. Studies have found that this product is more likely to cause sexual dysfunction than sertraline.
[Contraindications] Pregnant women, lactating women and those who are allergic to this product are prohibited.
【 Precautions 】 ① Fatal 5- hydroxytryptamine syndrome will occur when this product is combined with monoamine oxidase inhibitor. Therefore, the interval between the two drugs should be above 14d. ② Patients with hepatic insufficiency should be treated with small dose and closely monitored. ② Not recommended for children; The dose of elderly patients should be small and the increment should be slow. ④ Patients engaged in highly concentrated work should use this product with caution.
[Specification package] Tablets, 20mg, each box 14 tablets.
[Reference price] Retail price: 165.00 Yuan/box.
[Storage conditions] Sealed and stored at normal temperature (below 25℃), with a validity period of 5 years.
[Manufacturer] Denmark Lingbei Pharmaceutical Factory
[Import registration certificate number. ] X 1999043l