Bilirubin in the early stage of liver cancer is generally in the normal range, and there is no jaundice in clinic.
A small number of tumors located in special parts such as hepatic hilum can cause obstructive jaundice due to bile duct compression. Bilirubin gradually increased, indicating that the disease is in the late stage, mainly due to the compression of swollen cancer or serious damage to liver function. Leukocyte/globulin inversion is an important index of liver function decompensation. Because liver cancer is often complicated with chronic liver injury such as cirrhosis, it can often appear in the early stage, which is more obvious with the increase of liver cancer volume and the aggravation of liver function damage. Serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) is released into the blood due to liver cell injury, and the level of transaminase is an index to measure the degree of liver cell injury. Due to the damage of liver function, the production of coagulation factors is reduced, and the prothrombin time is prolonged, which is more than twice the normal value, suggesting that patients can not tolerate surgery. The obvious increase of GGT is mostly caused by huge tumor or portal vein tumor thrombus formation or active hepatitis, and the prognosis of patients with high GGT is poor.