2. National Essential Drugs and Xuefu Zhuyu Pill related national essential drugs retail guidance price information.
Essential drug serial number
DirectoryNo. Drug name, dosage form and specification Retail unit refers to
Remarks Price Category 689 52 Xuefu Zhuyu Pill Honey Pill 9g Pill 0.8 Chinese Patent Medicine Part * Note:
1. The dosage form specifications marked with "*" in the remarks column in the table are representative products.
2. Specifications of dosage forms with "△" in the remarks column in the table, and other specifications of the same dosage form are tentative prices.
3. The dosage form specifications are indicated in the remarks column. The prices of other specifications in this dosage form are based on the same usage and dosage, and are calculated according to the drug price comparison rules.
4. The "honey pills" marked in the column of dosage form in the form include small honey pills and big honey pills.
3 Pharmacopoeia Standard of Xuefu Zhuyu Pills 3. 1 Name Xuefu Zhuyu Pills
Xuefu Zhuyu Pill
3.2 Prescription Bupleurum 50g, Radix Angelicae Sinensis 150g, Radix Rehmanniae 150g, Radix Paeoniae Rubra 100g, Flos Carthami 150g, Semen Persicae 200g, Fructus Aurantii preparata with bran 100g, Radix Glycyrrhizae 50g, Rhizoma Chuanxiong 75g and Achyranthis Radix/kloc-.
3.3 pulverize the above eleven ingredients into fine powder, sieve and mix evenly. Every 100g powder is added with refined honey 1 10 ~ 130 g to make honeyed pills.
3.4 Characteristics This product is a brown honey pill; It tastes sweet and spicy.
3.5 Identification (1) Take this product, and observe it under the microscope: the oil tube contains yellowish or tawny strip secretion with a diameter of 8 ~ 25μ m (Bupleurum chinense). The diameter of the threaded catheter is 14 ~ 50μ m, and the thickened pipe walls are connected with each other, like a reticulated threaded catheter (Chuanxiong). Calcium oxalate crystals exist in parenchyma (Fructus Aurantii). Pollen grains are spherical or oval, about 60μm in diameter, with thorns on the outer wall and three germination holes (safflower).
(2) Take 9g of this product, add 6g of diatomaceous earth, grind it evenly, add 50ml of methanol, heat and reflux for 60min, let it cool, centrifuge for 5min, take the supernatant, evaporate to dryness, add 20ml of water to dissolve the residue, add 65438 00 ml of 50% ethanol and 65438±0ml of dilute hydrochloric acid, shake it evenly, and extract it twice with 25ml of ether. Adding another ferulic acid reference substance and methanol to prepare a solution containing 1 mg per 1 ml as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), on the same silica gel G thin-layer plate, 2 ~ 6 μ l of the test solution and 2μl of the reference solution were respectively absorbed, and toluene-ethyl acetate-formic acid (20:10/) was used as the developing agent, and then taken out. In the chromatogram of the test sample, spots with the same color appear in the position corresponding to the chromatogram of the control sample.
(3) Take the standby acid aqueous solution under [Identification] (2), shake and extract it with ethyl acetate twice, 25ml each time, combine the ethyl acetate extractive solutions (standby acid aqueous solution), wash with water twice, 25ml each time, discard the water washing solution, evaporate the ethyl acetate solution, and add 1ml methanol to dissolve the residue as the test solution. In addition, 65438±0g of Fructus Aurantii was taken as the control medicinal material, 65438±00ml of methanol was added, ultrasonic treatment was carried out for 65438±00min, and the filtrate was taken as the control medicinal material solution. Then take the naringin reference substance and add methanol to make a solution containing 1ml as the reference substance solution. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), 2 ~ 4 μ l of test solution, 2μl of control medicinal material solution and 2 μ l of control medicinal material solution were respectively spotted on the same high-performance silica gel G thin-layer plate, and the lower solution of chloroform-methanol-water (13: 6: 2) was used as developing agent. In the chromatogram of the test sample, fluorescent spots with the same color appear at the positions corresponding to the chromatograms of the reference medicinal materials and the reference substance.
(4) Take the standby acid aqueous solution under item [Identification ](3), shake and extract it with water-saturated n-butanol for 2 times, 20ml each time, combine the n-butanol extractive solutions, take half of the n-butanol solution (remaining amount for standby), wash it with ammonia test solution for 2 times, 20ml each time, discard the ammonia washing solution, evaporate the n-butanol solution, and add methanol 1ml to dissolve the residue as the test solution. In addition, 65438±0g of Achyranthes bidentata reference medicinal material is added with 25ml of 50% methanol, heated and refluxed for 65438±0h, cooled, filtered, and the filtrate is added with 20ml of water, and then shaken and extracted twice with 25ml of water-saturated n-butanol, and the n-butanol extracts are combined, washed twice with 25ml of water-saturated n-butanol, and the water washing solution is discarded, and then the n-butanol solution is evaporated, and methanol is added, and then the reference substance of β-ecdysterone is taken. According to the test of thin-layer chromatography (appendix ⅵ b of Pharmacopoeia I, 20 10), take 4 ~10 μ l of test solution, 6μl of control medicinal material solution and 2μl of control medicinal material solution, respectively, and spot them on the same silica gel GF254nm thin-layer plate. In the sample chromatography, spray 5% vanillin sulfuric acid solution on the spots with the same color at the corresponding positions, and heat them until the spots are clear. In the chromatogram of the test sample, spots with the same color appear at the position corresponding to the chromatogram of paeoniflorin reference substance.
(5) Take the remaining n-butanol extract under [Identification ](4), wash it with water for 2 times, 20ml each time, discard the water washing solution, evaporate the n-butanol solution, and dissolve the residue with 1ml methanol as the test solution. Take another 65438±0g of Glycyrrhiza uralensis Fisch, add 40ml of ether, heat and reflux for 65438 0h, filter, add 30ml of methanol to the residue, heat and reflux for 65438 0h, filter, evaporate the filtrate, add 40ml of water to dissolve the residue, shake and extract with n-butanol for three times, 20ml each time, combine the n-butanol extractive solutions, wash with water for three times, and discard. According to the test of thin-layer chromatography (Appendix ⅵ b of Pharmacopoeia Part I, 20 10), take 2 ~ 6 μ l of test solution and control medicinal material solution 1μl, and spot them on the same high-performance silica gel G thin-layer plate respectively. In the test chromatography, ethyl acetate-glacial acetic acid-formic acid-water (15:/kloc-)
(6) Take 9g of this product, add 6g of diatomite, grind it evenly, add 50ml of methanol, heat and reflux for 60min, let it cool, centrifuge for 5min, take the supernatant, recover the solvent under reduced pressure, evaporate to dryness, add 20ml of mixed solution of 7% sulfuric acid ethanol solution and water (1: 3) to the residue, put it in a water bath, heat and reflux for 3h, let it cool, and shake it evenly with chloroform. 20ml each time, discard the water washing solution, dehydrate the chloroform solution with appropriate amount of anhydrous sodium sulfate, filter, evaporate the filtrate, and dissolve the residue with 1ml methanol as the test solution. In addition, take Platycodon grandiflorum 1g, add 20ml of mixed solution of 7% sulfuric acid ethanol solution and water (1∶3), and prepare control medicinal solution by the same method. According to the thin-layer chromatography test (Appendix ⅵ b of Pharmacopoeia I, 20 10), 2 ~ 6 μ l of the test solution and 4μl of the control medicinal solution were respectively absorbed, spread on the same silica gel GF254 thin-layer plate with chloroform-ether (2: 1) as the developing agent, taken out, dried and placed under ultraviolet light (254nm). In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials. Spray with 10% sulfuric acid ethanol solution, heat at 105℃ until the spots are clear, and check in the sun. In the chromatogram of the test sample, the spots with the same color appear at the positions corresponding to the chromatogram of the control medicinal materials.
3.6 The inspection shall conform to the relevant provisions of Pills (Appendix VI A of Pharmacopoeia 20 10).
3.7 The content was determined by high performance liquid chromatography (Appendix ⅵ D of China Pharmacopoeia I, 20 10).
3.7. 1 chromatographic conditions and system applicability test, using octadecylsilane bonded silica gel as filler; 70% acetonitrile as mobile phase A and 0. 1% phosphoric acid solution as mobile phase B; The detection wavelength of paeoniflorin is 230nm, and that of naringin is 283nm. The theoretical plate number should be not less than 5000 calculated by paeoniflorin peak.
? Time (minutes)? Mobile phase A(%)? Mobile phase B(%)? 0~25 ? 24→40 ? 76→60 ? 25~26 ? 40→ 100 ? 60→0 ? 26~30 ? 100 ? 0 3.7.2 Preparation of reference solution Take appropriate amounts of paeoniflorin reference substance and naringin reference substance, weigh them accurately, and add 70% ethanol to make a mixed solution containing 30μg of paeoniflorin and 45μg of naringin per kloc-0/ml.
3.7.3 Preparation of test solution Take this product with poor weight, cut it into pieces, mix it evenly, take about 65438±0.0g, weigh it accurately, add 50ml of 70% ethanol accurately, weigh it, put it in a water bath for heating and refluxing for 45 minutes, let it cool, weigh it again, make up for the weightlessness with 70% ethanol, shake it evenly, and centrifuge (the rotation speed is per.
3.7.4 Determination Method Accurately absorb 10μl reference solution and test solution, inject them into liquid chromatograph, and determine to obtain the product.
Each pill of this product contains paeoniflorin (C23H28O 1 1), which shall not be less than 4.0mg, and the fried Fructus Aurantii with bran shall not be less than 8.7mg(c 27h 32 o 14) based on naringin.
3.8 Functions and indications: promoting blood circulation, removing blood stasis, activating qi and relieving pain. It can be used for treating chest pain, long-term headache, acupuncture local pain, internal heat and boredom, palpitation and insomnia, impatience and irritability caused by qi stagnation and blood stasis.
3.9 Usage and dosage Take it with brown sugar water on an empty stomach. 1 ~ 2 capsules once, twice a day.
3. 10 Pay attention to avoid spicy and cold food; Pregnant women are forbidden.
3. 1 1 specifications Each grain weighs 9g.
3. 12 storage seal.
3. The second supplement to People's Republic of China (PRC) Pharmacopoeia 20 10, version 3.
4. Standard of Xuefu Zhuyu Pill issued by the Ministry of Traditional Chinese Medicine 4. 1 Pinyin name Xuefu Zhuyu Pill
4.2 standard number WS3B007 189
4.3 Prescription Bupleurum 50g Angelica sinensis 150g Radix Rehmanniae 150g Radix Paeoniae Rubra 100g Flos Carthami 150g Semen Persicae 200g Fructus Aurantii (stir-fried with bran) 100g Radix Glycyrrhizae 50 g Rhizoma Chuanxiong 75g Radix Achyranthis Bidentatae 150g Radix Platycodi 75g.
4.4 Make eleven tablets according to the above preparation method, pulverize into fine powder, sieve and mix well. Every 100g powder is added with refined honey 1 10 ~ 130 g to make honeyed pills.
4.5 Characteristics This product is a brown honey pill; It tastes sweet and spicy.
4.6 The inspection shall comply with the relevant regulations under Pills (page 2 of the appendix).
4.7 Function indications: promoting blood circulation, removing blood stasis, activating qi and relieving pain. Used for blood stasis, headache or chest pain, internal heat, insomnia, dreaminess, palpitation, impatience and anger.
4.8 Usage and Dosage Take it on an empty stomach, 1 ~ 2 capsules with brown sugar water twice a day.
4.9 Pay attention to avoid eating spicy and cold food. Pregnant women should not take it.
4. 10 specification weighs 9g each.
4. 1 1 storage seal.
5 Instructions for Xuefu Zhuyu Pill 5. 1 Drug Name Xuefu Zhuyu Pill
5.2 Honey pill formula: each pill weighs 9g.
5.3 The main components of Xuefuzhuyu Pill are Bupleurum, Radix Angelicae Sinensis, Radix Rehmanniae, Radix Paeoniae Rubra, Carthami Flos, Semen Persicae, Fructus Aurantii (parched with bran), Radix Glycyrrhizae, Rhizoma Chuanxiong, Radix Achyranthis Bidentatae, Radix Platycodonis, etc.
5.4 Xuefu Zhuyu Pill is mainly used for promoting blood circulation, removing blood stasis, activating qi and relieving pain. Used for blood stasis, headache or chest pain, internal heat, insomnia, dreaminess, palpitation, impatience and anger.
5.5 Administration and dosage of Xuefu Zhuyu Pills: Take it with brown sugar water on an empty stomach, each time 1 ~ 2 capsules, twice a day.
5.6 Xuefu Zhuyu Pill should not be taken by pregnant women.
5.7 The adverse reactions of Xuefu Zhuyu Pill are not clear.
5.8 Precautions 1. Avoid alcohol, tobacco, spicy and fishy food.
2. It is not advisable to take nourishing Chinese medicine at the same time during medication.
3. Diabetic patients and those suffering from serious chronic diseases such as hypertension, heart disease, liver disease and kidney disease should be taken under the guidance of a doctor.
4. Children, pregnant women, lactating women, the elderly and the infirm, and loose stool with spleen deficiency should be taken under the guidance of a doctor.
If the symptoms are not relieved after taking the medicine for 3 days, you should go to the hospital.
6. It is forbidden for those who are allergic to this product, and should be used with caution for those who are allergic.
7. It is forbidden to use this product when its characteristics change.
8. Children must use it under the supervision of adults.
9. Please keep this product out of the reach of children.
10. If you are using other drugs, please consult a doctor or pharmacist before using this product.
5.9 Drug Interaction