Ji 'nan Shengquan Tanghetang Biotechnology Co., Ltd. Application Field

Tang and Tang L- arabinose are widely used in food and medicine. As people's eating habits become more and more scientific, the disadvantages of sugar become more and more obvious, and the harm of excess calories, metabolic disorder, obesity, hypertension, hyperlipidemia and diabetes becomes more and more serious.

People's requirements for quality of life are getting higher and higher, and traditional sugar is facing more and more severe tests. The daily intake of white sugar recommended by nutritionists is 30 ~ 40 grams. If you don't pay attention, this limit is very easy to break through. Moreover, more and more foods will add a lot of sugar sweeteners during processing, which is easy for us to consume too much sugar. "Being friends with sweetness and being enemies with sugar" has become a paradox that sugar has to face, and it is also the main contradiction that must be solved in seeking a breakthrough.

Jinan Shengquantang Hetang Biotechnology Co., Ltd. has been producing L- arabinose since 2008. The product quality is the best among peers, and the product content can reach above 99.5%. In view of this, since 2008, Tanghetang Company has cooperated with China Center for Disease Control and Prevention, China Academy of Sciences, Shandong Sugar Research Institute, Shandong University and other major scientific research institutions to do a lot of experiments on the application of L- arabinose in food.

Tang and Tang L- arabinose

Tang and Tang L- arabinose are white crystalline powder, odorless, with molecular weight 150. 13, melting point 159- 160℃, relative density 1.625, and sweetness about 60% of sucrose. It is easily soluble in water, but its solubility is slightly lower than sucrose.

Characteristic analysis of Tang and Tang L- arabinose

First, sense and taste.

The appearance of L- arabinose is white crystalline powder, and its sweetness is 60% of that of sucrose. Other indexes are consistent with that of white sugar. It can be said that L- arabinose is a good compound product and substitute product of white sugar.

Second, functional analysis.

A: The source hinders the absorption of sugar.

Diet is the only source of blood sugar. The food ingested by human body can only be decomposed into glucose under the action of glycosidase after reaching the small intestine; Only when sugar is decomposed into glucose can it be absorbed into the blood by intestinal mucosa and form blood sugar. It can be said that the level of blood sugar and the strength of glycosidase in small intestine are important determinants.

L- arabinose can not be converted into blood sugar by inhibiting the activity of glycosidase in small intestine and preventing food from being converted into glucose. Instead, L- arabinose is excreted through the digestive tract through feces, which blocks the production of blood sugar at the source, and also has a good effect on reducing the fat accumulation in animal viscera, slowing down weight gain, lowering blood pressure and inhibiting the increase of blood pressure.

B: Repair skeletal muscle and activate the body's own blood sugar regulation system.

Skeletal muscle is a striated muscle, which spans joints and attaches to bones. It is the dynamic organ of human movement. It can be said that every activity of our body is completed through the contraction of skeletal muscle. Skeletal muscle is closely related to the blood sugar level of diabetic patients. 85% of blood sugar in human body is converted into energy and physical strength through skeletal muscle utilization, and skeletal muscle is the key place for human body to utilize sugar. Secondly, skeletal muscle is responsible for more than 70% glycogen storage in human body. When human blood sugar is high, skeletal muscle stores excess sugar. When human blood sugar is low, skeletal muscle releases the stored sugar for the body to use, which helps stabilize blood sugar. Therefore, skeletal muscle is called the body's own blood sugar regulation system.

Normal skeletal muscle consists of red muscle fiber and white muscle fiber, in which red muscle fiber is responsible for most of the energy consumption and storage of human body, while white muscle fiber is of little use to blood sugar. Diabetic patients have weakened skeletal muscles, decreased red muscle fibers and increased white muscle fibers, so they can't store and utilize blood sugar normally. Diabetic patients are weak and tired, and their blood sugar fluctuates greatly.

L- arabinose can effectively repair the skeletal muscle of diabetic patients, increase the proportion of red muscle fibers, make the skeletal muscle stronger gradually, and thus improve the utilization rate of blood sugar. After the skeletal muscle is strong, the fatigue and fatigue of diabetes are completely improved, and the human body's own blood sugar regulation system is activated to achieve the effect of balancing blood sugar.

C: Improve intestinal microecology and proliferate beneficial bacteria.

The acidic environment in the intestine is conducive to the growth of beneficial intestinal flora such as Bifidobacterium and lactic acid bacteria, promoting the absorption of calcium by the body, enhancing the ability of the body to discharge toxic substances, and inhibiting the reproduction of harmful microorganisms.

L- arabinose has a good acidification effect on the intestine. Moreover, the physical and chemical properties of L- arabinose are similar to those of bifidobacteria such as fructooligosaccharides and soybean oligosaccharides: L- arabinose is not absorbed by human body, nor is it used by harmful bacteria, but is only used by bifidobacteria, which can proliferate probiotics in intestinal tract and promote human intestinal health. It can also be said that L- arabinose is a good bifidus factor.

The research results in Japan also show that women with constipation tendency will add sucrose containing 3%L- arabinose to drinks such as black tea and continue to take it, and the number of defecations per week will increase significantly. Sucrose added with 5%L- arabinose can also effectively promote the growth of Bifidobacterium.

D: increase high lipoprotein

High density lipoprotein (HDL), formerly known as human vascular scavenger, is a good lipid substance in our blood, which can clean the lipids in blood and reduce blood viscosity. At the same time, high-density lipoprotein can also reduce and prevent low-density lipoprotein from being oxidized (oxidized low-density lipoprotein can be deposited on the blood vessel wall, causing atherosclerosis)-1985. Dr. Brown of the United States won the Nobel Prize for discovering the important functions of high-density lipoprotein.

L- arabinose is the only substance that has passed the functional verification of China CDC and can effectively increase high-density lipoprotein. Experiments show that every 2.8 ml of arabinose can increase the content of high density lipoprotein by 20%. So as to clear blood fat, reduce blood viscosity and prevent cardiovascular and cerebrovascular diseases.

Application fields of Tang and Tang L- arabinose

The application of 1 L- arabinose in medicine

L- arabinose is an important intermediate in the synthesis of drugs, which can be used to synthesize cytarabine, arabinoside, D- ribose, L- ribose, deoxyribose and so on. Nucleoside antiviral drugs can also be synthesized, such as active reagent 1-(2- fluoro -5 methyl -β-L- arabinofuranose)-uracil (L-FMAU) against hepatitis B virus and Ep-stein-Barr virus, and new anti-hepatitis B drug telbivudine (nucleoside analogue, Idenix Company, USA). Changchun Institute of China Academy of Sciences has also developed a drug containing L- arabinose and galactose for the treatment of liver cancer.

L- arabinose has stable structure, good heat resistance, no calories and sweet taste similar to sucrose, and can be used as pharmaceutical excipients and fillers. Such as cough syrup, tablets and other different dosage forms.

2. Application status of L-arabinose in food

2. 1 directly replace sucrose as sweetener.

Japan introduced healthy sugar, and Tang and Tang introduced healthy white sugar, Nestle's companion sugar and other products. The main ingredients are sucrose and a certain proportion of L- arabinose, which are sold on supermarket shelves instead of white sugar, mainly for family consumption or direct use in the kitchen.

2.2 Functional sugar products for people with "three highs and one super"

Dafu Jiangtang, introduced by Tanghetang Company, is based on L- arabinose, combined with plant extracts such as chromium-rich yeast, bitter gourd extract and Polygonatum odoratum extract, which has obvious hypoglycemic and lipid-lowering effects and good market feedback. In addition, Tanghetang Company and Chinese Academy of Sciences and other institutions have also cooperated to develop functional health foods such as Xianshen Buccal Tablets (slimming) and Yangchang Tongtai (constipation).

2.3 Functional Instant Beverage

Chida Society has developed the best-selling instant slimming tea (Baikelina) in Japan, including oolong tea, black tea and original flavor, which is very popular in Japan. UNITIKA Company has developed an instant beverage containing cellulose (Nist Arabia), which can be added to water, tea and fruit juice for drinking. The main components of each package (6.2g) are 3.6g fiber and 0.3g L- arabinose.

2.4 Functional capsules

For example, ternary Lian Fang PLUS slimming capsule, its main components are potassium, L- arabinose, dextrin and so on. Control the absorption of sugar, water and salt through triple compound action to achieve the effect of losing weight; At the same time, vitamin C, folic acid, vitamin B group and other nutritional strengthening elements are added. Compared with other weight-loss products, it pays more attention to make up for the insufficient intake of energy and trace elements that may occur during weight loss and reduce the harm caused by weight loss.

2.5 Application in candy chocolate.

The L- arabinose chocolate developed by Tanghe Company can not only inhibit the increase of human blood sugar, but also improve the product quality and prolong the shelf life. The application of L- arabinose in candy and chocolate industry will receive great attention. L- arabinose not only has its own health care function, but also can help solve the problems of "frosting" of chocolate and "melting" and "returning to sand" of candy, and it is one of the new sugar sources to be developed in the next step.

2.6 Application in baked goods.

The molecular structure of L- arabinose is relatively stable and will not decompose at high temperature, so it can be used for baking food. Soft biscuit is a kind of biscuit that Americans like, but it is easy to get fat because of its high sugar content. Therefore, adding L- arabinose to these biscuits can inhibit the absorption of sucrose by human body, thus reducing people's fear of obesity caused by high-sugar biscuits. Similarly, adding a certain amount of L- arabinose to high-calorie foods such as cakes and egg yolk pies can reduce the unit energy density and attract more consumers. Tanghetang Company also studied that L- arabinose can improve the sense of Qifeng cake to a certain extent and has a strong inhibitory effect on the postprandial blood sugar increase of people with normal blood sugar.

2.7 Application in the field of flavors and fragrances

L- arabinose can be used not only in food and medicine, but also in perfume synthesis, chemical industry, biochemical reagents and so on. It is found that the reactive essence of L- arabinose can produce soft and rich aroma, which makes the aroma of the final product using this essence closer to nature and fullness. And since 20 1 1, Tanghe Company and well-known domestic scientific research institutions have started the application of L- arabinose in tobacco shreds to develop high-grade tobacco shreds.

Prospect of L- arabinose

Before 2008, L- arabinose production enterprises were mainly concentrated in a few countries such as Japan, Britain, Germany, Slovakia and Spain. Although the research on the development of L- arabinose in China is relatively late, with the improvement of people's living standards, the number of people with "three highs and one super" and sub-health has greatly increased, and the demand for L- arabinose products with unique health care functions will also increase sharply. Starting from 20 12, Jinan Shengquantang Hetang Biotechnology Co., Ltd. will make great efforts in the application research of L- arabinose, hoping to have more exchanges and cooperation with experts and customers from all walks of life on 20 12.