In the practice of diagnosis and treatment in the past thirty years, the author found that there are not many cases in which otolaryngology diseases really need systemic application of antibiotics (including oral administration, intramuscular injection, intravenous drip, etc.). However, the overuse of such drugs occurs from time to time. Such as chronic pharyngitis, chronic laryngitis, chronic rhinitis and chronic otitis externa. Unless the acute attack is caused by bacterial infection, it is unnecessary to use antibiotics in most cases. Not only does it fail to achieve the therapeutic purpose, but it may also cause adverse reactions, not to mention the cost.