Chinese name: menthol mbth: menthol other names: menthol indications: itchy skin and itchy skin diseases: colorless needle-like or prismatic crystals. Si Nuo. : 89-78- 1 Basic information, numbering system, safety information, physical and chemical properties, molecular structure data, computational chemical data, properties and stability, storage methods, main uses, preparations, manufacture from citronellal, manufacture from thymol, manufacture from peppermint oil, identification, pharmaceutical information, basic information Chinese name: menthol Chinese alias: (+/ Menthol; 2- isopropyl -5- methyl cyclohexanol; Thymol hexahydro; English name: DL- menthol, English alias: menthol; 2- isopropyl -5- methyl cyclohexanol; CASNo.: 89-78- 1 molecular formula: C 10 H 20 O molecular weight: 156.26500 exact mass:15100psa: 20.23000. I don't know :MFCD0000 1484 EINECSNo。 : 20 1-939-0 rtecNo.: OT0350000 BRNNo: 1902288 PublicationNo.: 2490 1226 Safety Information Customs Code: 290665438. 1888 6. 1/PG3WGK Germany: 2 danger category code: R36/37/38 safety description: s36/37/39-s24/25-s36-s26 rtecsno: ot0350000 dangerous goods symbol: Xi physical and chemical properties This product is one of the products extracted from peppermint oil. Also known as menthol and peppermint ice. Flammable, completely burning, smokeless when burning. The product is colorless needle-like or prismatic crystal or white crystalline powder; It has the special fragrance of mint and is cool after initial burning; The ethanol solution is neutral. This product is easily soluble in ethanol, chloroform, ether, liquid paraffin or volatile oil, and slightly soluble in water. Molecular structure data 1, molar refractive index: 47.83 2, molar volume (cm 3/mol): 175.53, isotonic specific volume (90.2 k): 409.84, surface tension (dyne /cm): 29.75, polarity (/kloc-. Kloc-0/, calculation reference value of hydrophobic parameter (XLOGP): 32, number of hydrogen topological molecular polar surface area (TPSA): 20.27, number of heavy atoms: 1 1 8, surface charge: 0.9, complexity:120/kloc-0. The number of uncertain atomic stereocenters is 0 13, the number of determined chemical bond stereocenters is 0 14, the number of uncertain chemical bond stereocenters is 0 15, and the number of * * * valence bond units is 1. The one on the left hand is a colorless needle crystal. Soluble in ethanol, miscible with oil. It has a cool, fresh and pleasant mint-specific aroma with a sweet prickly smell. It gives people a cold feeling, and the aroma is thorough, but it is not durable enough. The taste is also fresh and sweet. 2. It exists in flue-cured tobacco leaves, aromatic tobacco leaves and mainstream smoke. 3. It naturally exists in peppermint oil and Japanese peppermint oil, and a small amount exists in essential oils such as geranium oil. 4.*** has 12 isomer. 5. There is a little liquid oil and a little nonvolatile on the surface of ordinary crystal, and the synthesized menthol is a mixture of various isomers. 6. It is toxic, allergic and allergic. Storage method: This product should be sealed in a cool place. Main uses 1. Menthol and racemic menthol are both used as flavoring agents for toothpaste, perfume, beverage and candy. Medically used as a * * * medicine, it acts on the skin or mucous membrane, and has the effect of cooling and relieving itching; Oral administration can be used as a drug for expelling wind, such as headache, nasopharynx inflammation and so on. Its esters are used in spices and medicines. In the world, China and Brazil are the main natural peppermint producing areas, with an annual output of 2,000-3,000 tons of peppermint oil. Widely used in daily chemical essence, edible essence and cigarette essence. 1100 mg/kg in general chewing gum; 400 mg/kg in candy; Baked food130mg/kg; Ice cream 68mg/kg；; ; 35 mg/kg in soft drinks. 3. It has the functions of sterilization and antisepsis. 4. Used as a special additive for therapeutic cosmetics. Used for toilet water and so on. It can also be used as perfuming agent for toothpaste, perfume, beverage and candy. Used for making candy, beverage, spice and medicine. In preparation industry, peppermint oil and menthol are extracted from peppermint by steam distillation and organic solvent extraction. The former has low extraction efficiency, while the latter has the toxicity of residual organic solvents. Extracting menthol (menthol) from mint with supercritical carbon dioxide can eliminate the shortcomings of the above two methods. Its yield is about 5 times higher than that of steam distillation method and 3 times higher than that of organic solvent method. This product maintains its natural characteristics, with good quality, high purity, no residual toxicity of solvent, easy to meet the export requirements, good competitiveness and market occupation. Menthol can be purified or synthesized from natural peppermint crude oil. The aboveground part (stem; Branches; The essential oil obtained by steam distillation of leaves and inflorescences is called peppermint crude oil, and the oil yield is 0.5-0.6. There are many ways to synthesize thin brain. In the production of citronellal, D- citronellal was cyclized into L- isohumulol by acidic catalyst (such as silica gel), and L- isohumulol was separated and hydrogenated to produce L- menthol. Its stereoisomers can be partially converted into D- citronellal by thermal cracking and recycled. In the presence of m-cresol aluminum, m-cresol is alkylated to produce thymol. All four pairs of menthol stereoisomers (i.e., racemic menthol; Racemic menthol; Racemic isomenthol and racemic neoisomenthol). Distillation, removal of menthol fraction, repeated recrystallization after making ester, separation of isomers and optical resolution. Saponifying the separated L- menthol ester to obtain menthol. Racemic menthol can be separated from the other three isomers by distillation, and the remaining isomer mixture can be balanced into racemic menthol, racemic neomenthol and racemic isomenthol under the hydrogenation condition of thymol, with the ratio of 6: 3: 1, and the content of neoisomenthol is very small and can be ignored. Racemic menthol can be separated from the above mixture. Racemic menthol is inoculated with a saturated solution of benzoic acid ester or its supercooled mixture to crystallize levo-menthol, which is saponified after separation to obtain pure levo-menthol; According to the hydrogenation conditions, unwanted D- menthol and other isomers can be converted into racemic menthol in an equilibrium state. In the production of peppermint oil, peppermint oil is frozen to separate crystals, and the crystals obtained by centrifugation are recrystallized with low boiling point solvents to obtain pure L- menthol. The mother liquor after crystallization still contains 40% ~ 50% menthol and a large amount of menthone, which is converted into a mixture of L- menthol and D- neomenthol by hydrogenation. More L- menthol can be obtained by saponifying part of the ester, crystallizing, distilling or making its borate ester, and then separating the other parts of peppermint oil. Identification (1) Take this product 1g, add 20ml of sulfuric acid to dissolve it and turn it into orange red. After 24 hours, a colorless oil layer (different from thymol) without menthol flavor will precipitate. (2) Take 50mg of this product, add 1ml glacial acetic acid to dissolve it, and add 6 drops of cold mixed solution of sulfuric acid and 1 drop of nitric acid, which is only light yellow (different from thymol). Pharmacological action of drug information This product forms a conjugate with glucuronic acid, and after urine and bile excretion, various isomers combine with glucuronic acid in different amounts. It produces molecular degradation reaction in dogs and rats. It can exist as a metabolite of menthone. This product is easily soluble in ethanol, chloroform, liquid paraffin or volatile oil, and slightly soluble in water. Specific rotation: accurately weigh this product, add ethanol to make a solution containing 0. 1 ml, and measure it according to law. The specific rotation angle is -49 degrees to -50 degrees. Indications for external use are local pain relief, itching relief, headache, dizziness and mosquito bites; Nasal drip for cold nasal congestion and inhalation or spray for pharyngitis; Oral administration can strengthen the stomach. Drug interaction is often combined with camphor to enhance the antipruritic effect. Usage and dosage: external use on itchy skin, several times a day. 0.02 ~ 0. 1g, which can be taken in tablets. Or adde into medicine and ointment for external use on that affected part. Preparations and specifications menthol powder, ointment and tincture: 1% ~ 2%. Adverse reactions occasionally have local effects. Contraindications are prohibited for infants and young children. Store in a sealed and cool place. Poisoning first aid Because menthol has a * * * effect on skin and eyes and has certain toxicity, gloves and protective glasses must be worn when it is used in large quantities. 1. Inhalation: move the poisoned person to a ventilated place and take general first aid measures. 2. Wrong eye: It is necessary to consult a doctor when washing eyes according to the general steps. 3. Skin contact: Wash with water and soap. 4. Others: consult a doctor. Precautions do not apply to eyes and mucous membranes. The lethal dose of subcutaneous injection in rats is about 2g/kg body weight. It is very dangerous to use nasal drops or ointment containing this product in children's nasal cavity, which will cause collapse.