Atropine is an anticholinergic drug with the chemical formula of C 17H23NO3, and it is an M receptor blocker. Rachyoscyamine is extracted from Solanaceae plants such as Belladonna, Datura stramonium or Artemisia scoparia. Its alkali salt is colorless crystal or white powder, which is easily soluble in water.
Mainly relieve smooth muscle spasm, relieve small blood vessel spasm, improve microcirculation, inhibit gland secretion at the same time, relieve vagus nerve's inhibition on the heart, accelerate heartbeat, dilate pupils, raise intraocular pressure, excite respiratory center and relieve respiratory depression.
This product is easily absorbed from gastrointestinal tract and other mucous membranes, and can also be absorbed from eyes or a small amount of skin. It can be quickly distributed in the whole body tissue, can penetrate the blood-cerebrospinal fluid barrier and can also pass through the placenta. There are traces in all secretions, including milk.
Atropine action
It can compete with acetylcholine for acetylcholine M receptor on the postsynaptic membrane of parasympathetic nerve fibers, thus antagonizing muscarinic symptoms and central nervous system symptoms caused by acetylcholine overstimulation on the postsynaptic membrane. Clinically, it is often used to inhibit gland secretion, dilate pupils, regulate ciliary muscle spasm and relieve smooth muscle spasm of gastrointestinal tract and bronchus.
It can effectively control the muscarinic symptoms and central nervous system symptoms of organophosphorus pesticide poisoning. However, organophosphorus poisoning has a high tolerance to atropine sulfate, and the dose should be large enough.
Refer to the above content: Baidu Encyclopedia-Atropine