What is the second generation sequencing technology (NGS) and what are its advantages?

NGS, also known as high-throughput sequencing, can help identify gene mutations in tumors when traditional cancer treatment fails or doctors cannot determine the origin (main focus) of patients' cancer, which may be matched with some drugs for specific mutations. The main advantage of NGS is its large flux and large amount of data. The smallest data unit in Qualcomm is G, but the first generation sequencing can only produce 1K data at a time.

How useful is NGS for patients with advanced cancer? Research shows that:

1. Potential operable genomic variation was found in 80.5% of patients.

2. Among 132 patients treated under the guidance of sequencing, 37. 1% patients achieved clinical benefits, and 19.7% patients achieved hyperresponsiveness (defined as controlling their diseases for at least one year);

3. For cancer patients with unknown primary focus, NGS solved the problem of tissue traceability of nearly half (50.9%) cases, providing better clues for doctors to know which standard therapies and targeted therapies may be helpful;

4. In 15.8% of cancer patients, potential hereditary germ-line pathogenic variation (increasing cancer risk) was found, of which 4.8% was related to targeted therapy.

For more information about the second generation sequencing technology, it is recommended to consult Hyplos. Hyplos has original technology and core advantages in gene sequencing, liquid biopsy, biological information, big data and other fields, and its medical laboratory has the world's top gene sequencing platform and perfect international standard quality system. ● Is it necessary to do genetic testing if you are not sick? A n experienced person has something to say. ......