Individualized medication How to realize individualized medication?

In order to popularize the concept of individualized and differentiated medication and promote clinical safe, effective and economical medication, individualized medication is mainly based on clinical diagnosis and pharmacogenomics. However, with the completion of the human genome project and the arrival of the post-genome era, it is far from enough to carry out the so-called "individualized medication" only from the perspectives of age, gender and health status. Genetic variation is the fundamental factor of any phenotypic change, and genetic factors are the source of individualized differences in drug responses. The real individualized medication is to use advanced molecular biology technology (including gene chip technology) to interpret the drug-related genes (drug metabolizing enzymes, transporters and receptor genes) of different individuals. Clinicians can implement the drug administration scheme according to the patient's genotype data and use drugs reasonably according to the patient's situation. In order to improve the curative effect of drugs, reduce the side effects of drugs, and at the same time reduce the pain and economic burden of patients, this is gene-oriented individualized drug use, which represents the perfect combination of pharmacogenomics and clinical drug treatment and has epoch-making significance.

1999 April 16, the front page of The Wall Street Journal reported "Initiating a New Era of Individualized Drug Therapy —— Determining Drug Category and Dosage according to Individual Genotype", which keenly proposed the arrival of a new era of gene-oriented individualized drug therapy to the world. On March 22, 2005, the US Food and Drug Administration (FDA) issued a "drug genome data submission" guide for pharmaceutical companies. The purpose of this guide is to urge pharmaceutical companies to provide pharmacogenomic data of new drugs according to specific conditions when submitting new drug applications. Its purpose is to promote a more effective new "individualized medication" process, and finally use drugs according to "everyone's genetic status", so that patients can get the maximum drug efficacy and only face the minimum risk of adverse drug reactions. The new guidelines issued by FDA undoubtedly sounded the clarion call for human beings to March into "individualized medication based on pharmacogenomics".

The history of individualized medication in China, 200 1 year, successfully developed the world's first "gene chip for individualized medication of hypertension" for specific diseases. Individualized medication guidance and consultation center was established in 2004, individualized therapy gene analysis center was established in 2006, and Xiangya Medical Laboratory of Central South University was established on 20/0/0. The medical research results of "individualized medication" go out of the boudoir, so that more patients can achieve the effect of rational medication.