1. The metabolic function of cells decreases, and the body fat is easily oxidized, resulting in senile plaques. This pigment can not be excreted, so it is deposited on the cell body, thus forming senile plaques.
2. The metabolism in the body begins to decline, the decline of cell function accelerates year by year, and the blood circulation tends to slow down. In addition, the changes in the diet structure of the elderly and the imbalance in animal and plant fat intake have prompted a tiny brown particle called lipofuscin to accumulate in the basal cells of the skin. This brown particle is the product of lipid peroxidation. Aging tissues and cells lose their proper functions of decomposition and rejection, resulting in excessive brown particles accumulating in the basal layer of local cells, thus forming senile plaques on the surface of human body.
3. The activity of superoxide dismutase (SOD), which has anti-peroxidation effect in the body, is decreased, and the free radicals are relatively increased, which is the result of long-term poisoning of the body by free radicals and their induced peroxidation.
4. In the process of metabolism, the human body will produce a substance called "free radical", that is, lipofuscin, which accumulates on the surface of the human body and forms senile plaques.
When people are young and middle-aged, there are natural antioxidants and antioxidant enzymes in their bodies. These antioxidants can turn free radicals into inert compounds and cannot produce lipid peroxides, so they cannot damage cells. However, with the increase of age, the antioxidant function in the body gradually decreases, and the free radicals in the body will play a destructive role in old age. It is generally believed that senile plaque is a precursor plaque of tissue aging, indicating that cells have entered the aging stage. Lipoprotein not only accumulates on the skin, but also invades the body. If deposited on the blood vessel wall, it will cause vascular fibrosis, leading to arteriosclerosis, hypertension and myocardial infarction. When accumulated in brain cells, it will affect brain function and accelerate it.