First, the particle clock is introduced.
Microparticle seeds are cell membrane fragments with the size of 100- 1000nm produced by cell germination after apoptosis or stimulation. These particles mainly exist around activated platelets and have the function of promoting coagulation.
Its source cells include red blood cells, monocytes, white blood cells, lymphocytes, platelets, endothelial cells, photoreceptor cells, microglia, neurons and glial cells. The particle surface is rich in phospholipids and specific surface antigens of its source cells.
Second, the formation of particles.
The process of particle formation and release can be induced by many biological behaviors, including cell activation, aging and apoptosis. Studies have shown that the phenotype and quantity of microparticles formed in the same cell during activation and apoptosis are also different, which may be related to the mechanism of microparticle formation.
The mechanism of particle formation in the process of apoptosis mainly depends on Rho-related kinase (ROCKI), which is activated after being cleaved by caspase. The activated ROCKI can trigger cytoskeleton rearrangement and the release of apoptotic particles.
Many pathological processes can lead to cell activation or apoptosis to produce particles, while apoptosis in the eyes can lead to visual impairment or even blindness. Therefore, it is of great significance to study the biological function and mechanism of action of particles in ophthalmology.
The above information is for reference only. It is recommended to consult professional books or professionals for more comprehensive and accurate information.
Function of particle seeds
Coagulation promoting effect
Particle seeds mainly come from activated platelets, which can promote blood coagulation and blood coagulation.
Promote angiogenesis
Some microparticle seeds can promote angiogenesis, which is necessary for tissue repair and wound healing.
Pass the signal
The specific antigen carried on the surface of microparticle seeds can combine with recipient cells, transmit signals and affect the activation and function of cells.
Please note that the above information is for reference only, and the specific biological processes and mechanisms need further research and verification.