Domperidone tablets can relieve dyspeptic symptoms caused by delayed gastric emptying, gastrointestinal reflux and esophagitis, such as abdominal distension, abdominal distension, epigastric pain, belching, flatulence and heartburn, with or without intraoral reflux of gastric contents; It can also treat nausea and vomiting caused by functional, organic, infectious, dietetic, radiotherapy or chemotherapy.
catalogue
Basic information
Drug identification
Matters needing attention
Related diseases
pharmacokinetics
launch
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Basic information
Brief introduction of domperidone tablets
domperidone tablets
Drug Name Domperidone Tablets
The generic name of domperidone.
Trade name hengbang
English name domperidone tablets
Pinyin name domperidone tablets
Drug approval number National Medicine Zhunzi H 19990 107
Jiangsu haosen pharmaceutical co., ltd.
Primary pharmaceutical classification of digestive system drugs
Antiemetic drugs and emetic drugs are classified as Class II drugs in pharmacy.
Ingredients The main ingredient of this product is domperidone, and its chemical name is: 5- chloro-1[ 1-[3-(2- oxo-1- benzimidazolyl) propyl ]-4- piperidinyl ]-2- benzimidazolone. Molecular formula: C22H24ClN5O2
Character white block
Pharmacokinetic study showed that the peak of plasma concentration of domperidone tablets appeared 20-30 minutes after taking the drug. If you take the medicine about 30 minutes before meals, the drug effect is the strongest when the blood concentration reaches the peak, which has a good effect on increasing the tension of lower esophageal sphincter, enhancing gastric peristalsis, promoting gastric emptying and coordinating the movement of stomach and duodenum, so the symptoms of digestive system such as abdominal distension will be obviously alleviated.
Functional indications Domperidone tablets can relieve dyspeptic symptoms caused by delayed gastric emptying, gastrointestinal reflux and esophagitis, such as abdominal distension, abdominal distension, epigastric pain, belching, flatulence and heartburn, with or without reflux stomach contents in the mouth; It can also treat nausea and vomiting caused by functional, organic, infectious, dietetic, radiotherapy or chemotherapy.
Taking method
Usage and dosage: 1. Adults: 10mg 3-4 times a day, and the dosage can be doubled if necessary or as directed by the doctor. 2. Children: 3-4 times a day with a weight of 0.3mg per kilogram. This product should be taken before meals 15-30 minutes.
The adverse reaction was 1. Occasionally, there will be instant and slight abdominal cramps. 2. Sometimes the serum prolactin level will rise, but it will return to normal after stopping the drug. This effect is similar to that of many other drugs.
Pregnant women should use drugs with caution.
Children under 1 year-old cannot rule out the possibility of central side effects on infants under 1 year-old due to the imperfect development of blood cerebrospinal fluid barrier.
drug interaction
Anticholinergic drugs may antagonize the anti-dyspeptic effect of this product, so they should not be used together.
Specification10mg
Validity period: tentative five years.
Store in a dark place and keep it sealed.
manufacturer
2. Domperidone Tablets (National Medicine Zhunzi H20093779 Zhejiang Amlikang Pharmaceutical Co., Ltd. 86904606000337)
3. Domperidone Tablets (National Medicine Zhunzi H2009379 1 Shandong Lu Kang Chen Xin Pharmaceutical Co., Ltd. 86904 127004043)
4. Domperidone Tablets (National Medicine Zhunzi H20093772 Datong Yunhua Pharmaceutical Co., Ltd. 869028490007 18)
5. Domperidone Tablets (National Medicine Zhunzi H20093700 Changzhou Pharmaceutical Factory Co., Ltd. 8690 139700 1055)
6. Domperidone Tablets (National Medicine Zhunzi H2009349 1 Sichuan Vio Pharmaceutical Co., Ltd. 86902264000249)
7. Domperidone Tablets (National Medicine Zhunzi H20093426 Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd. 8690
domperidone tablets
4960000530)
8. Domperidone Tablets (National Medicine Zhunzi H20093370 Avis (Foshan) Pharmaceutical Co., Ltd. 869079 10000 17)
9. Domperidone Tablets (National Medicine Zhunzi H2009306 1 Revised Pharmaceutical Group Changchun Gaoxin Pharmaceutical Co., Ltd. 86903592000796)
10. domperidone tablets (national medicine standard H20093043 Xi ambohua pharmaceutical co., ltd. 8690246 1000547)
1 1. domperidone tablets (National Medicine Zhunzi H20084577 Harbin Pharmaceutical Group Sanjing Pharmaceutical Co., Ltd. 8690370600537)
12. domperidone tablets (National Medicine Zhunzi H20044 163 Hainan Asia Pharmaceutical Co., Ltd. 86905832000 139)
13. domperidone tablets (National Medicine Zhunzi H2003 1280 Tian Ping Pharmaceutical Factory of Shanghai Huashi Pharmaceutical Co., Ltd. 8690068 1000668)
14. domperidone tablets (National Medicine Zhunzi H20033864 Jiangxi Zhong Jie Biochemical Co., Ltd. 8690530300057)
15. domperidone tablets (National Medicine Zhunzi H200332 13 Xi Anrang Sang Pharmaceutical Co., Ltd. 86902529000 168)
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Drug identification
(1) Take a proper amount of fine powder of this product (approximately equivalent to domperidone 10mg), add dichloromethane-methanol (1: 1) 10ml, shake it evenly to dissolve, filter it, and take the filtrate as the test solution. Another proper amount of domperidone reference substance was dissolved in dichloromethane-methanol (1: 1) to prepare a solution containing 1mg per 1ml as reference substance solution. According to the TLC test, absorb 65438 00μ l of the above two solutions, respectively spot them on the same silica gel GF254 thin plate, and mix them evenly with ethyl acetate-dichloromethane-methanol-acetic acid buffer solution (pH4.7) (take 1mol/L acetic acid solution 10ml and 30ml water, and use/kloc-0. Diluted with water to 50 ml) (54:23: 18:5) as developing agent, dried after development, and inspected under ultraviolet lamp (254nm). In the test solution, the position of the main spot should be the same as that of the control solution.
(2) Take the solution under the content determination and determine it by spectrophotometry within the wavelength range of 220 ~ 320 nm. The absorption spectra of the test solution and the reference solution should be consistent. Functional indication
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Matters needing attention
1. Disabled for those allergic to this product.
2. Patients with pheochromocytoma, breast cancer, mechanical intestinal obstruction, gastrointestinal bleeding and other diseases are prohibited.
3. It is recommended that children use domperidone suspension.
4. Pregnant women should use it with caution.
5. Patients with heart disease (arrhythmia) and tumor patients receiving chemotherapy should use it with caution, which may aggravate arrhythmia.
6. If you have excessive or serious adverse reactions, please seek medical attention immediately.
7. When the nature of the drug changes, it is forbidden to use it.
Please keep this medicine out of the reach of children.
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Related diseases
Dyspepsia symptoms of gastro-intestinal reflux esophagitis with delayed gastric emptying. Abdominal distension, abdominal distension, epigastric pain, belching, flatulence, heartburn, nausea and vomiting.
This product is a peripheral dopamine receptor blocker, which can directly act on the gastrointestinal wall, increase the tension of lower esophageal sphincter, prevent gastroesophageal reflux, enhance gastric peristalsis, promote gastric emptying, coordinate the movement of stomach and duodenum, inhibit nausea and vomiting, effectively prevent bile reflux, and do not affect the secretion of gastric juice. This product is not easy to pass through the blood-cerebrospinal fluid barrier and has no inhibitory effect on dopamine receptors in the brain. Therefore, there are no neuropsychiatric adverse reactions such as extrapyramidal system.
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pharmacokinetics
It is absorbed quickly after oral administration, and the peak blood concentration can be reached in 15 ~ 30 minutes. The local drug concentration in gastrointestinal tract is the highest, followed by plasma, and almost none in brain. Almost all of this product is metabolized in the liver, and its half-life (t 1/2) is 7 hours. The total amount excreted through urine is 3 1.23%, and the original drug accounts for 0.4%. The total fecal excretion was 65.7%, and the crude drug accounted for 10%.