So is it necessary to amputate after diabetic foot appears? Of course not. There is no way to amputate, and drug treatment is the main measure to delay the development of vascular diseases. But if the drug has little effect, the method of vascular surgery also has certain effect.
Since diabetic foot is caused by insufficient blood supply to the foot, can't it be solved by artificial bypass to draw blood to the foot? Yes, this is a traditional surgical method, which surgeons often use for many years. When bypass, you must cross the diseased and narrow blood vessels, from the thigh root to the ankle, otherwise it will affect the blood supply in the distance. Generally speaking, the farther the bridge is built, the better the effect of protecting the distal limbs. Building a bridge is a building. Where do the materials come from? The easiest thing to think of is artificial blood vessels. After years of application, it is found that the effect of close-range application of artificial blood vessels is good. If it is too long, the probability of internal thrombosis leading to obstruction is very high. Where the knee joints cross, artificial blood vessels are often squeezed and blocked. The other material is the patient's own material, and the great saphenous vein running through the whole length of the lower limb is the most ideal. However, it is found that the great saphenous vein also has some shortcomings, that is, the ratio of mouth to diameter is small, and the blood supply is often not large enough. A considerable number of patients have problems with the great saphenous vein itself, and it is difficult to obtain the length of a leg. Dr. Friedman of Boston University in the United States combined two materials, one above the knee is an artificial blood vessel material, and the other below the knee is a great saphenous vein, which is called sequential bypass surgery, which not only meets the blood supply, but also reduces the probability of obstruction, and has been widely used in the world. In the application, we found that the connection of the second-stage graft and the connection of the distal end are the key points of the operation, so we improved these two parts. The joint of the two materials was originally connected to the human artery, but the artificial blood vessel is connected to the artery itself, and then connected to the artificial blood vessel from the great saphenous vein, which is beneficial to improve the local blood flow patency. The expansion of the distal joint of the ankle joint changed the direction of venous blood flow accompanying the artery. The injection point of great saphenous vein changed from one point to two points, and two boats were stepped on one foot, which created the outflow technique with * * * belt and promoted the blood flow.
Because sufficient blood supply is restored to the foot, the dying cells and tissues in the toe ulcer area quickly recover their vitality, and the ulcer can heal quickly. The patient feels that his feet are much warmer and his calves don't hurt when he walks. In the case of toe or partial foot necrosis, it is of course impossible to resurrect the dead. However, due to the abundant blood supply, the edge of the necrotic area will not continue to spread upward, and the dividing line between normal and abnormal tissues will become more and more obvious. Finally, the necrotic toe can fall off by itself, and when it is difficult to fall off, only the necrotic part needs to be surgically removed, which avoids high amputation caused by the foot, fully preserves the function of the limb, and is of great benefit to improving the quality of life of patients.
China has "bloodletting therapy", which is used on or under patients' necrotic skin.
Acupuncture is thorough, so that congestion is released, necrotic tissue is taken away, and foot ulcers will gradually improve.
A patent relieved ten thousand people from sores.
reading skills
By chance, physician Zhang Ping made up his mind to study the medical problems of skin sores. After continuous improvement, her formula and treatment became more and more mature, and she obtained a patent in China. So she turned to be a specialist, and now she has developed into a large-scale specialist hospital, which has relieved tens of thousands of patients.
The story tells us that the emergence of excellent patent achievements is accidental and inevitable; However, from the production to the implementation of patents, it is necessary to have a peaceful attitude to obtain extensive benefits.
Before interviewing Jinan Skin Ulcer Hospital, the reporter had got a copy of the hospital's information. In the thick folder, except for simple written materials, all the rest are photos of patients with skin ulcers. Canker wounds and bloody limbs can only be described as "terrible". It is hard to imagine that the patient will suffer such physical and psychological torture.
Some data show that wound nonunion and skin ulceration caused by various reasons are difficult problems in the field of medical research. Clinical treatment is usually skin grafting, amputation or declaring an incurable disease. Many patients face the tragedy of being amputated or paying the price of their lives.
However, Jinan Skin Ulcer Hospital has created a medical myth of "turning decay into magic". After careful treatment by the hospital, many patients from all over the country will save their limbs. Patients with unhealed wounds for more than ten years and decades have recovered to normal skin.
This stems from a China patent invented by Zhang Ping, the president of the hospital-"Shengji Transdermal Plaster".
Love drives doctors to fill in the gaps.
"This is not an ancestral secret recipe, but I slowly developed it myself." In the humble dean's office of Jinan Skin Ulcer Hospital, Zhang Ping talked to reporters about her patent.
Zhang Ping was a generation who grew up during the Cultural Revolution. As a student of workers, peasants and soldiers in that special era, her theoretical practice time in health school adds up to only two years. After graduation, he was assigned to Lixia District Hospital in Jinan and became a doctor. In the early 1980s, an old lady asked Zhang Ping to change her dressing during the Spring Festival, and she agreed. At that time, the old man had a thumb-sized ulcerated wound on his foot, which needed to be changed frequently. Knowing that the wound had not healed for eight years immediately aroused Zhang Ping's curiosity. As a physician, she has never studied this chronic skin ulcer in class, nor has she seen it in relevant materials. In the next few days, she tried to change several drugs for the old lady, but none of them worked. A doctor told her that he would give a plaque to anyone who could heal the wound. Zhang realized that the treatment of this disease is still a medical blank.
Zhang Ping, who likes challenges, consulted relevant experts everywhere in the following days and consulted ancient books and documents every day. From traditional Chinese and western medicine to folk remedies, she studied them one by one and finally became obsessed. Sometimes when I sleep until midnight, I suddenly have inspiration and suddenly call my sleeping husband to help.
For the ultimate success of this formula, Zhang Ping jokingly called herself "a blind cat catches a dead mouse", because it only took half a year, and the drug achieved satisfactory results, and the old lady with foot ulcer ended her eight-year illness. With her first success, Zhang Ping paid more attention to those patients with skin ulcers. On one occasion, she saw a patient with a fracture and plaster in the hospital surgery, and a large area of skin sores appeared. With a try attitude, she suggested that patients use her formula. And it worked.
After that, she constantly improved and perfected the formula. In her spare time, she keeps going in and out of the surgical ward of the hospital, making house calls from time to time and practicing medicine in patients' homes. Slowly, she gradually summed up a set of "trinity" therapy of oral Chinese medicine, external Chinese medicine and intravenous drip.
Parexdavco Medical Fine Patent Achievement Private Hospital
Miracles are constantly appearing, and their influence is growing. Later, with the support of the hospital, Zhang Ping left her job without pay, rented a hospital ward and set up a "skin ulcer treatment center".
Once, one of her patients told her that your prescription was so good that you should apply for patent protection. That was in 1993, and most people don't know what a patent is. Zhang Ping followed her words, sorted out her prescription and went to Shandong Patent Office to apply for an invention patent. 1997, her invention patent "Shengji skin-healing cream" was authorized.
The so-called skin ulcer is caused by diabetes, varicose veins of lower limbs, vasculitis, bedsore, burns, frostbite, traumatic fracture, osteomyelitis, postoperative wound nonunion, mosquito bite, anal fissure, anal fistula, hemorrhoids, genital inflammation and other reasons, and the incidence rate is high. With the increasing popularity of Zhang Ping, the rented hospital outpatient rooms are far from enough. With the help of relatives and friends, she bought a simple three-story building in Lixia District of Jinan City, and founded "Jinan Skin Ulcer Hospital" in 2003.
With more and more patients, the three-story building became cramped, and she converted the hospital into a six-story building. Up to now, more than 90 beds are far from meeting the clinical needs, and she is actively planning to expand the hospital.
"We have a statistic that all provinces and cities except Tibet have patients coming to see a doctor." Zhang Ping said. Since she invented this formula in 1985, tens of thousands of patients have been treated here, and most of them have recovered.
Create myths and write legends in hospitals.
Zhang Ping's office is full of photos of patients with skin sores. At first glance, most of the walls are covered with horrible pictures. A doctor in the hospital admitted that it was "very uncomfortable" for people who had never been a doctor to look at these photos. But in Zhang Ping's eyes, these photos have different meanings. Perhaps this represents a kind of responsibility and a kind of care.
Patient Dong is from Guide Town, Changqing District, Jinan City. 1In the summer of 996, Dong felt pain in his left shoulder, but the pain worsened after being treated in a local hospital, accompanied by redness and swelling. Soon, the muscle tissue began to turn black and fester. Dong's family hurriedly took him to a provincial hospital in Jinan and was diagnosed as "arteriovenous cellulitis". In just a few days, the hospital issued a critical notice after seeing that the whole left arm muscle fester and spread continuously, causing serious complications such as acute heart failure, acute renal failure and severe anemia. In desperation, Dong and his family came to Jinan Skin Ulcer Hospital with luck. At that time, more than 80% of the skin and muscles of Dong's whole left arm were necrotic in a large area, showing a honeycomb shape and extending to the armpit, and his face was bruised and severely deformed. In the face of this rare disease, all the medical staff present were shocked. Zhang Ping and the hospital experts immediately consulted and worked out a rescue plan.
A week later, the patient's affected limb gave birth to granulation, and the honeycomb necrotic tissue gradually disappeared, and the complications began to improve. After half a month, skin began to grow around the wound. Four months later, Dong miraculously recovered.
Ms. Su from Jiamusi City, Heilongjiang Province came to Jinan for medical treatment with her elderly mother. Ms. Su told experts that her mother's left foot was scarred by burns 30 years ago. Seven years ago, a small crack appeared on the scar, which gradually expanded and festered. In order to treat her mother, Ms. Su once took her mother to seek medical advice all over the country. However, it has brought them disappointment again and again. Ms. Su, who is eager to treat her mother, extensively searched the Internet for hospitals to treat this disease. She saw the information that Jinan Skin Ulcer Hospital can treat skin ulcers, so she came to Jinan with the psychology of giving it a try. In just 9 days, bright red granulation tissue appeared on the ulcerated foot surface, and the skin gradually healed. Mother and daughter never dreamed that seven years of illness finally saw hope here.
On the wall of the hospital office hangs a banner presented by an old general in jinan military area command: "Excellent medical skills, the crown of apricot trees". It turned out that two years ago, Mrs. General's left foot was necrotic and ulcerated due to diabetic gangrene. After being diagnosed by a military hospital, she had to undergo amputation. After learning this news, the old general, who had been a soldier all his life, endured grief and comforted his wife to accept this cruel reality, but he still couldn't bear to let her leave a disability regret in her later years. After being introduced, Zhang Ping was invited to the military hospital for consultation. After careful diagnosis, Zhang Ping thinks that the old man's feet don't need amputation, and even the festering toes can be saved. In order to be prudent, Zhang Ping went to the military hospital for treatment after reaching an agreement with the military hospital. Two days later, the inflammation of the patient's wound began to disappear obviously. This made the general overjoyed and immediately decided to transfer to Jinan Skin Ulcer Hospital for treatment. After more than 40 days of careful treatment, the general's wife fully recovered. Experts from the military hospital heard the news and saw the therapeutic effect, and repeatedly praised: "Miracle! Miracle! "
Qufu peasant woman week. Last June, I accidentally fell on my right foot while riding a bike and got 6 stitches in the local health center. Since then, the wound has not healed, and it has been treated in local hospitals and several hospitals in Jinan, the provincial capital, but it has not improved. Finally, it was diagnosed as diabetes by the provincial hospital, resulting in unhealed wounds. The only clinical treatment is amputation, or you will pay the price of your life. As a result, her right leg was amputated below the knee for more than 60 thousand yuan in medical expenses, and this middle-aged peasant woman became a lifelong disability. But bad luck didn't leave. Before long, the surgical wound began to fester, and waiting for her would be a high amputation. In desperation, Zhou and her husband came to Jinan Dermatosis Hospital with the desire to survive. After understanding the situation, Zhang Ping and his colleagues said with regret: "If you had come earlier, you wouldn't have lost this leg. It's a pity. " The next treatment made the miracle reappear, watching the wound heal day by day, and Zhou was sad and happy; Although he lost a leg, his life was saved, which made the unfortunate Zhou and her husband see the hope of life.
It is difficult for private hospitals to develop and break through the bottleneck of funds.
Zhang Ping told reporters that the hospital is in a new stage of development, and like other small and medium-sized enterprises, there are also financial difficulties. This is because their operating costs are higher. First, the charges for patients are low; Second, they make house calls all over the country, resulting in huge travel expenses; Third, they often reduce fees for patients with family difficulties.
It is reported that a demobilized soldier who has been "sentenced to death" by the hospital wanted to leave the provincial capital Jinan and go home to "wait for death". The patient's brother inquired about the hospital. When I came, my shoulders were ulcerated and empty. After plain examination, it was diagnosed as "bone tuberculosis". The patient was on the verge of death many times during the debridement treatment. It was Zhang Ping and the doctors who saved him from death. When I was discharged from the hospital, because the patient's family was poor, I owed 50 thousand yuan for medical expenses. The hospital proposed to recover only the cost and reduce the rest of the expenses. However, the patient disagreed, insisting that his life was saved by the hospital and he could not owe the hospital money. Finally, 50,000 yuan was collected and handed over to the hospital. Zhang Ping said that this is the highest medical fee she has received since she opened the clinic. However, she explained that the cost was relatively high because of the need to rent an operating room in the hospital. At present, most patients spend only 3000 ~ 4000 yuan on the whole treatment, 1000 yuan or more.
In recent years, hospitals have reduced or even subsidized patients' funds and accumulated a lot.
From outpatient service to hospitalization, all investments are gradually accumulated. Zhang Ping said that she did not accept any investment during this period. However, as a private hospital, it is difficult to make a breakthrough only by its own meager accumulation.
"There are still a large number of patients waiting for our treatment in the society, and the existing conditions in the hospital are far from meeting the needs of patients. They need improvement, expansion, equipment, talents and popularity. This requires funds. " Zhang Ping finally said, "I hope someone can invest, expand the scale of the hospital, and let more patients relieve their pain."
Reporter's testimony
The nth mode of patent implementation
Among the patent holders contacted by reporters, there are generally several ways to implement patents: one is to transfer, that is, to sell their patents cleanly; Second, cooperation, signing a cooperation agreement with the management, and jointly implementing it to obtain long-term benefits; Third, self-implementation, that is, raising funds to develop their own patented products. Due to the different nature of patented products, various realization methods also have their own advantages and disadvantages in practice.
Zhang Ping's way of implementing patents seems to be somewhat special, and the reporter called it "the nth mode".
Its particularity lies in that the implementation of the patent of "Shengji Transdermal Plaster" started with the minimum investment, and gradually accumulated and expanded. Although during this period, Zhang Ping also cooperated with a pharmaceutical factory, for various reasons, during the contract period, she did not get a profit commission, but only got tens of thousands of yuan of cooperation funds according to the contract, which is obviously not enough compared with large private hospitals.
The birth of original invention patents often embodies the inventor's huge investment of money, time, energy and wisdom. But in many cases, big efforts do not mean good market returns-this is determined by market demand and project operation ability. Practice has proved that "Shengji Transdermal Plaster" has a broad market prospect. At present, it is not a luxury to transfer a "sky-high price". However, this "sky-high price" was gradually accepted and recognized by the society in the process of Zhang Ping's personal implementation. On the other hand, if Zhang Ping directly transfers the patent without clinical practice and asks for a million dollars, I'm afraid the possibility of success is very small. Maybe this patent is still sleeping. At least, tens of thousands of patients have been relieved of their pain and gained a new life through this patent. Judging from their contributions to medicine and the promotion of humanistic spirit, their merits are boundless and cannot be measured by money.
Not every patent's social value can be gradually highlighted like this. As an inventor, Zhang Ping's desirable feature is "peace of mind".
"Zhuangzi Zapian Lieyukou" said: Zhu Ping learned to slaughter dragons in pieces, and it was the home of a single daughter. Three years of skill, but no originality in using it. Paying for her daughter to learn dragon slaying is an expense that only the rich can afford, but no matter how exquisite her skills are, she has nothing to do after graduation, so it is better to kill pigs and cows. According to the ancient master-apprentice rule, learning to kill pigs means working with the master for free at most, and the cost is extremely low. After finishing my studies, I can support my family soon. I will not be rich, but I will not starve. There is a market when there is demand, a harvest when there is a market, and a success when there is harvest. This is the most shameless rule of market economy. Therefore, Mr. Liu Xuemin, a well-known management consultant, believes that the teacher who can "sell" the Dragon Slayer for thousands of dollars is the biggest winner in the market economy.
Whether a patent project is a "gold bar" or a "straw" is ultimately determined by the market and always depends on the recognition of consumers and the public. It takes time to test, it needs to overcome many difficulties and practice boldly to achieve "peace of mind", it needs to constantly improve patented technology, and it needs to master more market information and more market rules. The most important thing is that you can't "make big money" in this process, otherwise you may go to the opposite side.
Even if it is priceless and beautiful, it may not be recognized without thinking. This is an important connotation of the N-th patent implementation mode.