What is exciting in recent years is the development of predictive genetic testing. Using genetic testing technology, we can find risks before diseases occur, prevent them early, or take effective intervention measures. At present, more than 20 diseases can be predicted by genetic testing.
When testing, the subject's genes are first extracted from blood or other cells. Then, this part of genes can be replicated many times by primers and PCR technology, and whether there is mutation or sensitive genotype in this part of genes can be judged by mutation gene probe method, enzyme digestion method and gene sequence detection method with special markers.
Our usual medical detection means is to detect the specific symptoms or existing lesions of the disease. The development of modern science has promoted the continuous development of medical examination methods, and we can make a detailed analysis of diseases vertically or horizontally.
Question 2: What are the genetic testing items? Genetic testing can be used to diagnose diseases and predict the risk of diseases. Disease diagnosis is the use of gene detection technology to detect mutant genes that cause hereditary diseases. At present, the most widely used are the detection, diagnosis and auxiliary diagnosis of hereditary diseases in newborns. At present, there are more than 1000 diseases that can be diagnosed by gene technology.
Using genetic testing technology, we can find the risk of diseases before they occur and prevent them in advance. There are more than 20 kinds of diseases that can be predicted through genetic testing.
When testing, the subject's genes are first extracted from blood or other cells. Then, these genes can be replicated many times by primers and PCR technology that can identify genes that may mutate. After replication, there are many ways to judge whether there is mutation in this part of the gene. Such as probe method, enzyme digestion method, gene sequence detection method of special marker mutant gene, etc.
Question 3: What is genetic testing? Is there any specific content? Genetic testing is a technique to detect DNA through blood, other body fluids or cells. Genetic testing can be used to diagnose diseases and predict the risk of diseases. Disease diagnosis is the use of gene detection technology to detect mutant genes that cause hereditary diseases. At present, the most widely used genetic testing is the detection of neonatal hereditary diseases, the diagnosis of hereditary diseases and the auxiliary diagnosis of some common diseases. At present, there are more than 1000 kinds of genetic diseases that can be diagnosed by gene detection technology. What is exciting in recent years is the development of predictive genetic testing. Using genetic testing technology, we can find the risks before the disease occurs, prevent it early or take effective intervention measures. At present, more than 20 diseases can be predicted by genetic testing. When testing, the subject's genes are first extracted from blood or other cells. Then, this part of genes can be replicated many times by primers and PCR technology, and whether there is mutation or sensitive genotype in this part of genes can be judged by mutation gene probe method, enzyme digestion method and gene sequence detection method with special markers. At present, the methods of gene detection mainly include fluorescence quantitative PCR, gene chip, liquid biochip and microfluidic technology.
Question 4: Gene gene examination: What excellent genes can be detected through oral mucosa? The detection items of excellent genes include gifted gene decoding, 36 tumor risk genes decoding, 150 major diseases decoding, 150 common diseases decoding, infertility gene decoding, perfect baby gene decoding, tumor and common disease molecular typing gene decoding, and 100. These are not expensive, ranging from 3000 yuan to tens of thousands of yuan. In addition, it is more scientific to charge for good learning genes mainly according to the complexity of the genes analyzed and evaluated.
Question 5: What is the use of genetic testing? What do you mainly test? 1. Find the susceptible genes in our body in time and take preventive measures as soon as possible. 2. Genetic testing is a technique to detect DNA through blood, other body fluids or cells. It is to take the oral mucosa cells or other tissue cells shed by the examinee, amplify their genetic information, and then detect the DNA molecular information in the examinee's cells by special equipment, and analyze the various genes contained in them, so that people can know their own genetic information and predict the risk of diseases, so as to avoid or delay the occurrence of diseases by improving their living environment and habits.
3. Central Plains Sheikh genetic testing suggests that you use genetic testing technology to find risks before diseases occur, prevent them in advance, or take effective intervention measures.
Question 6: What are the meanings of gene testing? Which genes are the codes of life, and are the manipulators and regulators of life? Genes can not only transmit genetic information to the next generation through replication, but also express genetic information. Genetic differences between people determine differences in birth, growth, old age, illness, death, appearance, personality, habits, hobbies and so on. More importantly, genes are closely related to diseases. Except for trauma, almost all diseases can be detected by genetic testing, that is, avoiding unfavorable factors in a targeted manner, so that diseases are not displayed and diseases are truly prevented. So? First, let's learn what genetic testing is. 1. What is genetic testing? Genetic testing is called "disease susceptibility gene testing". It extracts DNA substance from exfoliated cells of human oral mucosa for specific detection, judges whether it is susceptible to diseases from the perspective of genetics, predicts the risk of future diseases, gives early warning to the risks of common diseases, and provides targeted health intervention guidance. So as to actively improve their living environment and habits and prevent and avoid the occurrence of major diseases. Second, what is the difference between genetic testing and routine physical examination in hospitals? Routine physical examination is usually once every six months or once a year, which is to check whether you are sick now and buy time for clinical treatment. Genetic testing only needs 1 test for the same project in human life, which is to predict the inherent risk of the subject's disease. Through the guidance of professional doctors, let the subjects pay attention to their usual living and eating habits, prevent the expression of pathogenic genes, and win time for preventing major diseases. The international common method is painless, harmless, non-infectious, safe and reliable for gene detection and sampling by scraping the oral mucosa of the subjects. It takes 15 working days from sampling to issuing the Genetic Physical Examination/Personalized Health Guidance Report. 3. What is the significance of genetic testing? All diseases are related to genes, which are functional fragments carrying genetic information on DNA molecules and substances that organisms transmit genetic information. Genes dominate life and are the foundation of life. 1, predictive medicine: the risk of diseases can be accurately predicted in both healthy and sub-healthy periods. 2. Disease prevention: disease = internal cause+external cause. Through the understanding of internal causes, the influence of external causes can be effectively avoided, thus reducing the risk of illness. 3. Health management: If you know that you have a certain disease susceptibility gene through genetic testing, you can actively improve your environment and living habits and do your own health management. 4. Personalized medical service: Through genetic testing, we are reminded which drugs to use with caution, which not only greatly reduces unnecessary medical expenses, improves the curative effect, but also avoids causing greater harm to the human body. Four. Significance of genetic testing For people who have already suffered from the disease, genetic testing can help clinical diagnosis, and can make up for the functional defects caused by susceptible genes according to the carrying situation of susceptible risk genes, so as to carry out corresponding treatment and prevent the disease from getting worse. Significance of breast cancer risk gene detection 1. Know the risk of breast cancer as soon as possible: Genetic testing can evaluate the genetic risk of breast cancer by detecting breast cancer-related loci. Genetic testing shows that people with high genetic risk of breast cancer can avoid the risk factors of breast cancer as soon as possible and delay or prevent the occurrence of breast cancer. 2. Guide personalized life: Unhealthy lifestyle is also a risk factor for breast cancer. For people with high risk of breast cancer according to genetic test results, it is necessary to avoid related unhealthy lifestyles. Maintain peace of mind, maintain relative endocrine balance, balance diet, avoid adverse environment, and actively treat benign breast lesions. 3. Auxiliary diagnosis of breast diseases: genetic testing (risk grade) can be used as an auxiliary diagnosis method of breast diseases, and the results can provide doctors with a basis for one-dimensional judgment. 4. Guidance on rational drug use: Genetic testing can prompt the sensitivity of individuals to certain drugs and the metabolic ability of poisons, and guide rational drug use, especially the safe use of estrogen-related drugs and the use of drugs related to detoxification and metabolism in human body. 5, help predict the risk of offspring: about 15%-20% of breast cancer patients have a family genetic history.
Question 7: What are the items of genetic testing and what is the cost? You can do children's talent testing, adult susceptibility testing, obesity gene testing, disease testing, cardiovascular drug testing, cardiovascular and cerebrovascular disease testing ... A lot, of course, the specific cost varies according to the testing items, hundreds of times, you can go to official website to check the details (Zhongyuan-Sheikh).
Question 8: What items are included in children's genetic testing? There are many, such as IQ, EQ, art, sports, diseases and so on. You can make one according to your child's situation. After all, the future of the child is the most important. Genetic testing of children in Zhongyuan Concord mainly includes 2 categories, 8 items and 98 items. I hope it helps you!
Question 9: What is the cost of genetic testing? For different testing items and different sequencing platforms, the price of gene testing ranges from several hundred yuan to tens of thousands of yuan.
The price of genetic testing mainly depends on the number of genes you detect, and the detection of a single system is about 5000 yuan. If you are interested, welcome to take a look at Zhongyuan Concord Gene.
A common disease ***(7 1)
Digestive system (7 items): esophagitis, nonalcoholic fatty liver disease, gallstones, pancreatitis, ulcerative colitis, Crohn's disease, colorectal adenoma.
Respiratory system (4 items): asthma, acute lung injury, idiopathic pulmonary fibrosis, emphysema.
Circulatory system (item 12): atherosclerosis, coronary heart disease, atrial fibrillation, acute coronary syndrome, myocardial infarction, dilated cardiomyopathy, hypertrophic cardiomyopathy, hypertension, hypertensive nephropathy, cerebral hemorrhage, cerebral infarction and deep vein thrombosis.
Immune system (9 items): rheumatoid arthritis, rheumatic arthritis, rheumatic heart disease, lupus erythematosus, autoimmune hepatitis, Behcet's disease, Kobayashi Harada syndrome, scleroderma, multiple sclerosis.
Nervous system (9 items): insomnia, migraine, cluster headache, depression, cognitive decline, Alzheimer's disease, vascular dementia, paroxysmal ataxia, Parkinson's disease.
Endocrine system (project 12): 1 diabetes, type 2 diabetes, insulin resistance, diabetic nephropathy, diabetes complicated with cardiovascular diseases, metabolic syndrome, hypertriglyceridemia, dyslipidemia, obesity, gout, hypothyroidism and exophthalmos.
Five senses (6 items): high myopia, cataract, age-related macular degeneration, angle-closure glaucoma, polypoid choroidal angiopathy, otosclerosis.
Blood system (project 1): polycythemia vera.
Skin motor system (6 items): vitiligo, psoriasis, Kawasaki disease, osteoporosis, lumbar disc herniation, osteoarthritis.
Genitourinary system (5 items): polycystic kidney disease, hereditary nephritis, hysteromyoma, endometriosis and polycystic ovary syndrome.
Tumor diseases (29 items)
Digestive system (7 items): esophageal cancer, gastric cancer, primary liver cancer, gallbladder cancer, extrahepatic cholangiocarcinoma, pancreatic cancer and colorectal cancer.
Respiratory system (3 items): nasopharyngeal carcinoma, laryngeal carcinoma and lung cancer.
Nervous system (2 items): glioma, meningioma.
Endocrine system (project 1): thyroid cancer
Five senses (1 item): oral cancer
Blood system (5 items): acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, multiple myeloma and malignant lymphoma.
Skin motor system (2 items): basal cell carcinoma and osteosarcoma.
Genitourinary system and breast (8 items): renal cancer, bladder cancer, sporadic breast cancer, prostate cancer, testicular cancer, cervical cancer, endometrial cancer and ovarian cancer.
Question 10: What is the use of genetic testing? What do you mainly test? 1. Purpose:
1) Auxiliary clinical diagnosis: Many diseases have similar symptoms, so it is difficult to differentiate and diagnose clinically, and it is easy to be confused. If the cause is found at the genetic level through genetic testing, it can assist clinicians in differential diagnosis and even correct clinical diagnosis.
For example, Huada Gene tested a family suspected of "congenital cataract-keratoconus syndrome" and finally found that their family actually suffered from "vitreoretinopathy" rather than "congenital cataract-keratoconus syndrome" at the genetic level, which helped them correct their clinical diagnosis.
Another example: a special type of diabetes is "monogenic diabetes" (caused by a single gene mutation, which is a Mendelian hereditary disease. ) Because of its gene defect, patients are obviously different from 1 type or type 2 diabetes in metabolic characteristics, clinical manifestations and treatment schemes. However, due to lack of understanding, monogenic diabetes is often mistaken for 1 type or type 2 diabetes. An epidemiological survey in the UK shows that 80% of patients with late adolescence diabetes (MODY) have not been correctly diagnosed. In the study of monogenic diabetes in Europe and America, it is found that 1 0% of 10% of diabetes and 2-5% of type 2 diabetes are actually monogenic diabetes. Therefore, by screening the pathogenic genes of monogenic diabetes in normal people, especially those with family history of diabetes, gene defects can be found as early as possible, so as to distinguish patients with monogenic diabetes from patients with 1 type or type 2 diabetes.
2) Guiding treatment: The effect of treatment is related to many factors, and the differences between people are mainly influenced by genetic factors. Genetic testing helps to realize individualized treatment, improve curative effect and reduce the occurrence of adverse reactions.
3) Carrier screening: Down syndrome is the most common screening. The traditional screening for Down's syndrome is carried out by serological screening, and the detection rate is 65%-75%, which is easy to miss the diagnosis. Noninvasive prenatal genetic testing can accurately screen children with Down syndrome, including 18 trisomy syndrome and 13 trisomy syndrome. In addition, screening related pathogenic genes for high-risk population with family history of some monogenic genetic diseases (especially recessive genetic diseases) can find out the carrying situation of pathogenic genes in this family in time, and then analyze the disease risk of future generations, provide effective genetic information for family members and prevent defective genes from being passed on to the next generation.
4) Fertility guidance: According to the results of genetic testing, combined with different genetic patterns of diseases, fertility guidance is provided through genetic counseling. Help to give birth to a healthy baby through prenatal diagnosis (after natural pregnancy) or IVF combined with pre-implantation screening or diagnosis.
5) Provide accurate matching information for hematopoietic stem cell transplantation: Patients with thalassemia, mucopolysaccharidosis and leukemia who need hematopoietic stem cell transplantation must be HLA typed to evaluate the incidence of rejection after transplantation. Huada Gene adopts the "gold standard" of international HLA typing method-gene sequencing method, which provides a high score of 4 digits, provides accurate typing information for transplantation, and finds the most suitable donor faster. It can detect HLA-A, -B, -C, -G, -DRB 1, -DRB3, -DRB4, -DRB5, -DQA 1, -DQB 1. Huada Gene independently developed and applied NGS to detect HLA, realizing the low-cost detection mode of HLA Qualcomm.
2. Test content:
Gene mutations that can be detected by gene detection include: changes in the base composition or arrangement order of gene-specific DNA sequences due to various factors inside and outside the body, resulting in changes in the primary structure of DNA. Gene detection mainly detects various changes of gene sequence, including single base change (SNV), insertion & deletion of large or small sequence fragments (insertion & deletion of one or more nucleotides in DNA sequence, InDel), copy number variation (CNV), structural variation (SV), dynamic mutation and so on. At present, the main types of mutations detected are single nucleotide mutation (SNV), insertion deletion mutation (InDel) and copy number mutation (CNV).
I. General genetic testing ... >>