1, too much uric acid is produced. This may be due to diseases, such as leukemia, chronic kidney disease, multiple osteomas and so on. This may lead to excessive uric acid production, or it may be due to the lack of enzymes that metabolize purine, and uric acid will increase with age.
2, uric acid excretion decreased. The abnormal function of kidney in dealing with uric acid may lead to the decrease of uric acid excretion. 90% patients with persistent hyperuricemia have abnormal renal function when dealing with uric acid, including inhibition of renal tubular secretion, increase of renal tubular reabsorption and decrease of glomerular filtration.
3. Bad eating habits. If patients drink too much, overeat, often eat barbecues, drink polysaccharide drinks, and eat foods with high purine content, it will lead to the inability of the body to excrete purine, and then the uric acid value will increase.
Please note that the above is only general information, and the specific reasons may vary from person to person. If you have any health problems, it is recommended to consult a professional doctor or obtain accurate information from authoritative sources.