What are the ways for drugs to reach the appendix from great saphenous vein injection?

Antibiotics pass through great saphenous vein, femoral vein, external iliac vein, common iliac vein, inferior vena cava, right atrium, right ventricle, pulmonary artery, alveolar capillary, pulmonary vein, left atrium, left ventricle, ascending aorta, aortic arch, thoracic aorta, abdominal aorta, superior mesenteric artery, ileocolic artery, appendix artery, and appendicitis area of medial malleolus.