John young, professor, doctoral supervisor, winner of National Natural Science Foundation "Outstanding Youth Fund", "Outstanding Young Scholar" of Shandong University and "Qilu Young Scholar" of Shandong University, has been engaged in signal transduction and structure research of GPCR for a long time, accumulated rich experience and made important progress in this field. In the process of studying the signal transduction mechanism of GPCR, the "flute model" of GPCR phosphorylation coding was revealed, which solved the core problems that have plagued this field for a long time and promoted the development of this field (Nature Communications 2015, Facility1000, Molecular Pharmacology 2017, cover article); The allosteric control mechanism between GPCR and SH3 protein was clarified, and it was found that Arrestin had catalytic effect, which broke the previous concept that Arrestin was just a "linker" protein, which was not only a conceptual innovation and breakthrough, but also an important new discovery of the signal transduction law of GPCR. (Natural Chemistry Biology 2018); A 1 H NMR probe was developed, which can detect the conformational changes of low concentration GPCR complexes in a few minutes. Using this probe, the mechanism of ligand regulating Arrstin through the transmembrane core region of GPCR was first clarified, which provided a theoretical basis for precise drug design (Nature Communications 2020). Taking itch receptor, bile acid receptor and prostaglandin receptor as targets, the structural basis of ligand recognition and bias signal pathway of GPCR was revealed, and the corresponding intervention strategies were formulated, which provided theoretical and structural basis for precise treatment of GPCR. In nature (2020,2021), NAT Chem Biol. (20 18)，Nat Commun。 (2015,2020, recommended by instructor 1000), J Clin Invest. (2065438+). Currently, he is a member of ion channel and membrane receptor branch of Chinese Neuroscience Society, member of biochemical and molecular pharmacology committee of Chinese Pharmacology Society, and member of biochemical and renal pharmacology committee of Chinese Pharmacology Society.