The newly recruited vice president and top leader of the company asked me to give up my office. What do you mean? Can I refuse?

If this happens in the workplace, you will be in danger and can't refuse. You need to find out from your own reasons, whether you are not serious about your work or not handling your work according to the boss's wishes! Although the newcomer is different from the department you are in charge of, if you let go of the office, you may make mistakes in your work, but you don't know it yet. I suggest you talk to your boss and tell him how to improve your work and how to cooperate with the new vice president in the next step.