1:250,000 is divided into 16 pieces on the basis of 1: 1 10,000, that is, it is divided into/kloc-from left to right according to longitude difference 1.30 minutes and latitude difference 1.06 minutes.
1:50,000 is formed on the basis of 1: 1 10,000. Your coordinate number on 1: 18 is I-49- 1 18, which is on the map of 1:50000.
I-49- 188-B, the formula is too complicated to apply. Just find a tutorial on map framing on the internet and compare it.