22. The bioavailability comparison of the following dosage forms is generally correct.
A. powder >; Granules > capsules B. capsules >; Granule > powder medicine
C. particles >; Capsule > powder D. powder = granule = capsule
E. incomparable
23. The following main materials can be used as hard capsule shell.
A. Glycerol B. Water
C. sucrose D. gelatin
E. starch
24. Soft capsules have good elasticity, mainly because they contain
A. Moisture B. Gelatin
C. glycerol D. sucrose
E. starch
25. Drugs that should not be made into soft capsules are
A. vitamin A oil solution B. vitamin C solution
C. vitamin d oil solution
E. Vitex negundo oil
26. The following statement about capsules is incorrect.
A. It is better absorbed than tablets and has high bioavailability. B. It can improve the stability of drugs.
C. it can avoid the first-pass effect of the liver. D. it can cover up the smell of drugs.
E. the main route of administration is oral administration.
27. Which of the following drugs should be made into capsules?
A. Weathering drugs B. Drug aqueous solution
C. hygroscopic drugs D. drugs with bitter taste or odor
E. dilute ethanol solution of drugs
28. Effervescent particles produce a lot of bubbles when they meet water because the acid in the particles reacts with alkali to produce gas, which is
A. Hydrogen B. Carbon dioxide
C. Oxygen D. Nitrogen
E. Other gases
29. Drugs that do not need to be crushed separately are
A. Oxidizing drugs B. Drugs with the same properties
C. Precious drugs D. Reducing drugs
E. irritant drugs
30. About the content of disintegrant, the description is wrong.
A. The function of disintegrant is to overcome the binding force formed by adhesive or press into tablets.
B effervescent disintegrant consists of citric acid or tartaric acid plus sodium carbonate or sodium bicarbonate.
C. internal addition is beneficial to the dissolution of drugs
D. The external application method is beneficial to the disintegration of the drug.
E. the order of disintegration speed is: internal and external addition >; Neijia >; External application method
3 1. The statement about tablet granulation is wrong.
A. increase the bulk density of materials to make air escape B. reduce fine powder flying
C. Improve the fluidity of raw materials D. Avoid powder delamination.
E, reduce the friction between the tablet and the die hole.
32. Compound acetylsalicylic acid tablets are not suitable for adding the following excipients.
A. starch slurry D. talcum powder
C. starch D. liquid paraffin
E. magnesium stearate
Reference answer and analysis?
22A. Analysis: The bioavailability of solid preparations is affected by the drug particle size. The smaller the particle size, the faster the drug absorption and the higher the bioavailability.
23D. Analysis: The main material of hard capsule shell is gelatin.
24C. Analysis: Soft capsule materials are made of gelatin, glycerol or other suitable pharmaceutical excipients alone or in combination. Soft capsule shell has great elasticity and plasticity. Its elasticity depends on the weight ratio of dry gelatin, dry plasticizer and water in capsule shell. Commonly used plasticizers are glycerol, sorbitol or their mixture.
25B. Analysis: aqueous solution is not suitable for preparing soft capsules, and vitamin C solution belongs to aqueous solution.
26C. Analysis: Capsules are oral preparations, which need to be absorbed into the blood in the gastrointestinal tract after administration. Drugs absorbed through the gastrointestinal tract have the first-pass effect of the liver, and capsules are no exception.
27D. Analysis: Oily or W/O emulsion is suitable for making capsules.
28B. Analysis: The effervescent preparation contains sodium bicarbonate and organic acid, which can react chemically in water to generate carbon dioxide.
29B. Analysis: The purpose of pulverizing drugs separately is to prevent different drugs from reacting or influencing each other, so drugs with different properties need to be pulverized separately, and drugs with the same properties do not need to be pulverized separately.
30E. Analysis: The order of disintegration speed is: internal and external addition >; Add method > internal add
31e. analysis: granulation and solid preparation are the same operating unit, and its purpose is: ① to improve liquidity. (2) Prevent segregation of components. (3) Prevent dust from flying and adhering to the wall. ④ Adjust the bulk density to improve the solubility. ⑤ Improve the uniform transmission of pressure in tablet production. ⑥ Easy to carry and improve the value of goods.
32E. Analysis: Acetylsalicylic acid in compound acetylsalicylic acid tablets is unstable in alkali and prone to hydrolysis reaction, while magnesium stearate is weakly alkaline, so magnesium stearate is not suitable for compound acetylsalicylic acid tablets.
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