(2) Using cDNA array technology and protein analysis method, we searched for new effector molecules and transcription regulators in Th 1 and Th2 cells, and studied their effects on cell differentiation and function. In the experiment, Th 1 cell mediated organ-specific autoimmune disease mouse model and Th2 cell mediated allergic mouse model, as well as T cell receptor transgenic mice and various gene knockout mice were used to confirm the function of the new gene. These studies will clarify the regulatory mechanism of DC on Th 1/Th2 cells, provide innovative academic ideas for explaining the differentiation mechanism of Th 1 and Th2 cells, and provide new ideas and drug targets for immune intervention and treatment of immune diseases mediated by Th 1 and Th2 cells, such as autoimmune diseases, organ transplant rejection and allergic diseases, as well as infections and tumors caused by hypoimmunity.
(3) Borrowing bioinformatics and gene recombination technologies, such as DNA immunization and DC targeted immunization, provide new scientific research ideas for new vaccine design and antibody preparation, and apply the results to practice. To provide experimental data for the diagnosis, treatment and prevention of diseases.
The laboratory has good scientific cooperation with NIH, Yale University, MD, Anderson Cancer Research Center and Columbia University, and they will provide us with technical support and information consultation.