Hepatitis B is not a genetic disease, but an infectious disease. Are you a man or a woman? For men, the probability of vertical transmission between father and baby is small. If the mother is fine, as long as the child is vaccinated on time after birth, the problem is not big. However, it is recommended to explain to his wife that she should be vaccinated and have antibodies before marriage and pregnancy.
If you are a woman and your liver function is normal when you are pregnant, it will not affect your child's development, but you must check your liver function regularly. Because the liver burden of pregnant women increases with the growth of children, abnormal liver function must be treated in time to avoid affecting the development of children and the risk of bleeding during childbirth. The viral load of pregnant women in big Sanyang will not be low, because hepatitis B E antigen is an indicator of viral replication, and a high drop of E antigen in pregnant women indicates that viral replication is active. Evidence-based medical evidence shows that mothers with high viral load have a higher probability of vertical transmission from mother to child, almost twice as much as mothers with low viral load. Therefore, mother-to-child blocking is very important! At present, the clinical application of immunoglobulin to pregnant women is no longer advocated. Immunoglobulin is a neutralizing antibody. For the people in the third world, that immunoglobulin does not play any role, wasting money and playing a psychological comfort role. If HBVDNA is really too high, on the basis of informed consent of pregnant women, telbivudine 600mg can be added in the third trimester.
Once a day or lamivudine 100 mg
Qd) Don't be smart enough to add them together. I have met such a patient. These two drugs are theoretically used as Class B drugs, which are also supported by a large number of clinical cases, but after all, they are drugs with special physique and unpredictable risks, so don't add them together); Within 24 hours after the baby is born, inject hepatitis B high-efficiency immunoglobulin and hepatitis B vaccine at different parts (10ug, which is 5ug for babies with HBsAg negative mothers under normal circumstances), and allow another injection of hepatitis B high-efficiency immunoglobulin on 15 days. In addition, infants were vaccinated with hepatitis B vaccine at 1 month and 6 months respectively. If you follow the above steps, the blocking rate of infant hepatitis B virus infection is 93-97%.
Regarding breastfeeding, the content of HBVDNA in breast milk is very low, which is not prohibited in theory. However, the nipples of primiparas are delicate and prone to chapped nipples and bleeding. Breastfeeding is not recommended at this time. For those with high load (quintic copy is greater than 10), the state recommends breastfeeding. The 20th10 version of China's guidelines for the prevention and treatment of chronic hepatitis B also says that breastfeeding is not a big problem.