What is the pharmacokinetics of Retting (Anastrozole Tablets)?

Hello, anastrozole tablets have a miraculous effect on the treatment of breast cancer patients. Retting (anastrozole tablets) is absorbed quickly, and the maximum blood concentration usually appears within 2 hours after taking the drug (on an empty stomach). Ruiting (anastrozole tablets) has a slow clearance, and the plasma clearance half-life is 40-50 hours. Food has a slight effect on the absorption rate, but it does not affect the absorption degree. When taking this tablet 1 time daily, the slight effect of food on the drug absorption rate will not affect the plasma steady-state concentration. After 7 days, the plasma concentration can reach 90-95% of the steady-state concentration. There is no evidence that the pharmacokinetic parameters of Retting (anastrozole tablets) are time or dose dependent.

Retting (anastrozole tablets) is widely metabolized in postmenopausal women, and less than 10% of the dose is excreted in urine within 72 hours after taking it. Metabolic processes include N- dealkylation, hydroxylation and glucuronide acidification. Its metabolites are mainly excreted in urine, and triazole, the main metabolite in plasma, does not inhibit aromatase activity. The apparent clearance rate of the drug taken orally by patients with stable cirrhosis and renal insufficiency is within the observation range of healthy volunteers. (Content source: Kang Aiduo New Special Medicine Room Network)

The age of postmenopausal women does not affect the pharmacokinetics of this product. The pharmacokinetics of this drug has not been studied in children. The plasma protein binding rate of Retting (anastrozole tablets) is only 40%.