The initial reaction of endogenous coagulation system is firstly

The factor is activated.

According to the information in Dr. Bohe's network, endogenous coagulation is mostly caused by the activation of 12 factor in patients. Endogenous coagulation pathways are usually formed after binding with accessories and surfaces, and the initial reaction of endogenous coagulation system is that factors are activated first.

Most of the initiating factors of endogenous coagulation are caused by the endogenous coagulation pathway that touches the negative surface, so it needs to be detected.