⑵ Analgesic effect: ① Hot plate method: After taking Tongjingbao in mice, the pain threshold of animals at each observation time point after administration was significantly higher than that before administration (P < 0.001~ 0.05); In the high dose group, the pain threshold increased by more than 50% within 65438 0 20 minutes after administration. ② writhing method: After taking Tongjingbao orally, the writhing times of mice induced by intraperitoneal injection of 0.5% acetic acid were significantly lower than those of the blank control group (P < 0.01~ 0.001); The latency of writhing was also significantly prolonged (P
⑶ Effect on the uterus of experimental animals: ① Effect on the isolated uterus of rats: Tongjingbao can effectively inhibit the spasmodic contraction of isolated uterus of rats caused by oxytocin, and all dosage groups can significantly reduce the contraction range of isolated uterus (P
⑴ Overall curative effect: The total effective rate of Tongjingbao Granule in treating dysmenorrhea of cold coagulation and blood stasis type was 92.00%, and the remarkable effective rate was 62.33%. No obvious adverse reaction was found in clinical verification.
⑵ Test results of dysmenorrhea pain items: After treatment, the patient's lower abdominal cold pain and degree score were significantly improved.
⑶ Efficacy of TCM syndromes: There was significant difference between the treatment group and the control group before and after treatment.
⑷ Symptoms improvement before and after treatment: There were statistically significant differences in symptoms such as less abdominal cold pain, less menstrual blood, unsmooth menstrual blood, blood clot, menstrual color, breast pain, chest tightness, chills or hypothermia in hands and feet before and after treatment (P < 0.05).
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