Hippophae rhamnoides L.-a green life plant in 21century
Seabuckthorn belongs to Elaeagnus family, and its English name is "Seabuckthorn". In Latin, "Seabuckthorn" is commonly known as vinegar willow, which means "shining horse" in Latin.
The definition of Hippophae rhamnoides L. is a kind of medicinal food containing various vitamins, trace elements, basic acids and other bioactive substances.
Seabuckthorn:
Plants that have lived on the earth for more than 200 million years;
Plants that can survive in the harsh environment of deserts and mountains;
"Cancer of the Earth"-the only plant that can grow in soft sandstone areas;
Develop plants with the highest ecological and environmental protection value in the western region;
Green plants that grow completely in pollution-free environment;
Recognized as the king of Vc in the world plant world;
A plant widely used in China Chinese Medicine Code and World Pharmacopoeia;
Medicinal and edible plants recognized by the Ministry of Health.
The story of seabuckthorn
Legend: It is said that an ancient primitive tribe, a group of sick old horses, could not bear the punishment of herders and was exiled to the vast Shan Ye. However, the horse hesitated to go. It was this year that he suddenly heard the crowing and neighing of horses outside the tent. Looking at it, he is dignified and radiant. The herdsmen thought that there was God's help, and they followed him. When they left Shan Ye, the magical "fruit of wisdom" appeared. At this point, people call this plant "Hippophae rhamnoides", which is a shining horse.
During the Three Kingdoms period, Zhuge Liang led troops south to Yunnan, and the generals were exhausted and there was nothing they could do. Suddenly, they saw a colorful thorn fruit in the wilderness, and their physical strength increased greatly. This great victory is really the help of "thorn fruit"
Long medicinal history and in-depth scientific research.
* China Hippophae rhamnoides L. has a long history of medicinal use, which is the earliest recorded country in the world. * In ancient China, Tibetan medicine and Mongolian medicine listed Hippophae rhamnoides as an important medicinal plant for relieving cough and asthma, promoting blood circulation and removing blood stasis.
* Four Medical Codes, a masterpiece of Tibetan medicine in the 8th century A.D., recorded the efficacy of Hippophae rhamnoides in detail.
* In A.D. 1840, Zhu Jing Materia Medica, a classic work of Tibetan medicine, also recorded the characteristics of seabuckthorn.
Medical function,
* In modern times, Tibetan and Mongolian compatriots in remote areas still use seabuckthorn to treat various common diseases.
* 1977 Hippophae rhamnoides L. was officially listed in China Pharmacopoeia by the Ministry of Health of China for the first time. Later, the State Administration of Medicine and the Ministry of Health jointly announced that Hippophae rhamnoides L. was a medicinal and edible homologous plant.
* Seabuckthorn roots, leaves, flowers, fruits and seeds can be used as medicine. In particular, fruit contains many vitamins that the human body can't synthesize, which is indispensable for people's physical and mental health. They are known as "the miracle of plants in the world" and a treasure house of vitamins.
* A complete seabuckthorn fruit has only one seabuckthorn seed, 1000 seabuckthorn seed is less than10g seabuckthorn seed oil, 20t seabuckthorn fruit is extracted 1t seabuckthorn seed, and 250ml seabuckthorn oil needs100kg seabuckthorn fruit concentration.
* Seabuckthorn oil contains 206 active substances beneficial to human body. Experts who have been engaged in seabuckthorn medicinal research for decades in the former Soviet Union said: "It is irreplaceable medicinal value of seabuckthorn to combine so many active substances skillfully and organically." This determines the position of seabuckthorn oil as "the essence of medicine and the king of oil".
* Seabuckthorn resources account for110 of the earth's resources, mainly distributed in China, accounting for more than 80% of the earth's resources. Wutai Mountain area is the main distribution area of seabuckthorn in China because of its unique geographical position.
Biologists and chemists in the former Soviet Union have conducted in-depth research on the biological composition, biochemical composition and biomedical value of Hippophae rhamnoides L., and found that there are nearly 200 kinds of active components, which are very rare in the existing plant resources on the earth, and are called magical fruits, creating a precedent for medical application. After birth, the Ministry of Health of the former Soviet Union approved more than a dozen medical approval numbers, and conducted a lot of clinical medical research. It was found that Hippophae rhamnoides really has very precious medicinal value, especially in the treatment of burns and drugs.
* Since 1980, Chinese medical workers have done a lot of research on the pharmacology, pharmacodynamics, toxicology and clinic of Hippophae rhamnoides. The famous domestic Xi Medical University, China-Japan Friendship Hospital, China Academy of Traditional Chinese Medicine, Sichuan West China Medical University, Shanxi Medical Research Institute and Gansu Medical Research Institute have conducted in-depth and detailed research on Hippophae rhamnoides. It is found that Hippophae rhamnoides L. has good medicinal value in human respiratory system, digestive system, immune system, metabolism, cardiovascular and cerebrovascular system, anti-aging and so on. At present, there are drugs on the market for treating burns, ulcers, gastric ulcers and anti-tumor with Hippophae rhamnoides L. oil as the main component.
In addition to its precious medicinal value, seabuckthorn is more important for the social value of ecological environment and land management. In the process of western development, serious desertification, desertification and soil erosion in the west bear the brunt. Because of its special root structure and tenacious vitality, Hippophae rhamnoides, a plant gold mine buried for many years, a precious ecological resource and a wonderful fruit of Buddha's fate, finally ushered in a golden opportunity.
2 1 the hope of human health and longevity in the century
In order to reveal the magical medical function and value of Hippophae rhamnoides L., scientists conducted in-depth research on the biochemical components of Hippophae rhamnoides L., and found that Hippophae rhamnoides L. is rich in vitamins (ve, VC, VP, VK, VB6, VB 12, etc. ), carotenoids (β-carotene), unsaturated fatty acids (linoleic acid, linolenic acid, palmitic acid, etc. ) and flavonoids (flavonoid glycosides, flavonoid glycosides). Trace elements (iron, copper, zinc, potassium, calcium, etc. ), amino acids (aspartic acid, etc. ), organic acids (malic acid, oxalic acid, etc. ), phospholipids (lecithin, cephalin, phosphatidylinositol) and anti-tumor 5- hydroxytryptamine, anthocyanin, coumarin, etc. It is closely related to the ecological stress resistance of seabuckthorn. It can balance nutrition, regulate function and metabolism according to different physiological systems of human body, thus playing a comprehensive health care role for human body. It is praised by international medical and nutrition experts as the most promising nutrition, health care and medicinal plants for human beings in 2 1 century.
With the arrival of the new century, mankind has gradually entered an aging society, and the health of the elderly has become the focus of social attention. The World Health Organization (WHO) has listed cardiovascular and cerebrovascular diseases, malignant tumors and diabetes as the three major killers of human beings. In the face of the disaster of this century, western medicine pharmacy, which is mainly based on chemical synthetic drugs, has limited the drug treatment of a single disease, with great side effects, and patients can not take it for a long time. The development of modern Chinese medicine science with plant extracts as the core has been able to solve these problems. In recent years, medical experts have turned their attention to this ancient plant, Hippophae rhamnoides. Studies have shown that the rich biochemical components in Hippophae rhamnoides L. are very beneficial to human absorption, and have a very unique role in regulating various functions, balancing nutrition, restoring functions, regulating metabolism and resisting aging. But also can be taken for a long time without any toxic or side effects, and plays an irreplaceable role in preventing and treating various cardiovascular and cerebrovascular diseases, malignant tumors, digestive system diseases, diabetes, liver diseases, kidney diseases and the like. Seabuckthorn is known as a green life plant for human health and longevity.
As can be seen from the above, Hippophae rhamnoides, an ancient earth plant of the same age as Ginkgo biloba, was gradually unveiled by people with the deepening of modern medical, pharmacological and biochemical research. It will be presented to mankind in the new century with a brand-new look, and it will make great contributions to human health with its precious ecological environment value, great social and economic value, special nutrition and health care value and precious medical value.
Four kinds of medicinal plants are covered with treasures
Seabuckthorn is a treasure everywhere, and almost all of it can be used as medicine.
● Fruit: divided into juice, pulp, peel and seeds.
Fruit juice contains a lot of VC, VE, carotene, flavonoids, trace elements, amino acids, organic acids and so on. It is an excellent raw material for making drinks and can also be used to extract flavonoids.
The pulp contains a lot of flavonoids and fruit oil, which is the main raw material for extracting flavonoids and making cosmetics.
Peel mainly contains peel oil, which can be used as raw materials for food, nutrition, washing products, skin care products and health care products, and is rich in nutrition.
Fruit seeds contain seed oil, protein, etc. It is an important raw material for extracting seabuckthorn seed oil.
● Leaves: contain leaf oil, various amino acids, flavonoids, trace elements, protein, etc. It can be used to extract leaf oil, which has extremely high nutritional value. Seabuckthorn leaves are mainly used to make seabuckthorn tea, which has the functions of relieving cough, relieving asthma, relaxing bowels, diuresis and moistening lung.
Stem bark: the stem part of Hippophae rhamnoides L., which contains 5- hydroxytryptamine with anticancer activity and can be used as anticancer drug.
3 Seabuckthorn oil:
There are two kinds of fruit oil and seed oil. Seed oil has the highest medicinal value and is used in pharmacy and health care products. Fruit oil is mainly used in cosmetics, beauty products, skin care products and washing products.
Seabuckthorn oil soft capsule (health food)
The advanced supercritical CO2 extraction technology in the world is mainly used to extract medicinal vegetable oil from seabuckthorn seeds. The extraction temperature is normal temperature and high pressure, and there is no toxic or side effect. CO2 can play a protective role, retaining the bioactive components in oil to the maximum extent, and reaching the export and medical standards.
Seabuckthorn seed oil is rich in natural vitamin E, β-carotene, α-tocopherol, unsaturated fatty acids, flavonoids and so on. It is mainly used for preventing and treating various cardiovascular and cerebrovascular diseases, and has the functions of reducing blood fat, lowering blood pressure, preventing arteriosclerosis, improving blood circulation, etc. It has the most obvious effect on various ischemic cardiovascular and cerebrovascular diseases caused by hyperlipidemia. In addition, seabuckthorn oil also contains 5- hydroxytryptamine, coumarin, tetrandrine and other effective anticancer components, which can inhibit malignant tumors, prevent tumor spread, improve the tolerance and autoimmune of tumor patients to radiotherapy and chemotherapy, restore the vitality of the body, improve appetite and sleep, and is an auxiliary therapeutic drug for tumor patients.
Seabuckthorn oil contains active substances such as VA, which can effectively regulate gastrointestinal function and cure gastrointestinal ulcer. The effect is very obvious, and it is an excellent drug to prevent gastric and duodenal ulcers. At present, it has been listed in the new drug declaration of the Ministry of Health. At present, gastric ulcer has shown a trend of multiple occurrences, and there is no effective radical cure method in western medicine. Seabuckthorn oil can restore digestive function and heal ulcer site.
Main anticancer components of seabuckthorn oil and its mechanism
Main anticancer components and contents of seabuckthorn oil;
Seabuckthorn oil contains 5- hydroxytryptamine, catechin, bitter rosin, coumarin, isocoumarin, anthocyanin, ginkgetin, betaine, terpenoids, SOD, phenolic flavonoids, VA, VB 1, VB2, VE, sitosterol, unsaturated fatty acids and other anticancer active components.
The main contents are as follows:
VC 1200mg/ 100g carotenoid 200mg/ 100g.
Ve 220/100g 5- hydroxytryptamine 0.3%
Vp1500mg/100g VBI 0.3/100g
VB2 0.5mg/ 100g SOD 2746 unit.
Unsaturated fatty acid 80%
Carotenoids can be transformed into VA, which plays an important role in the differentiation and maturation of epidermal cells and maintaining their structural integrity. Can guide epidermal cells to develop in a mature and hornless direction; It can also inhibit the process of pre-carcinogens strengthening into carcinogens, eliminate chemical carcinogens and reduce the adhesion of carcinogens such as benzopyrene on the cell surface; It can also kill major cancer cells by activating T-Saba cells and stimulating antibody production.
VA can prevent and treat skin cancer, gastric cancer, esophageal cancer, oral cancer, laryngeal cancer, colon cancer, rectal cancer, bladder cancer, cervical cancer, uterine body cancer, renal cancer, thyroid cancer, breast cancer, prostate cancer and gallbladder cancer. VA can prevent all tumors originating from epithelial tissue.
VE can inhibit the formation of nitrosamines, and has the functions of antioxidation, inhibition of free radicals and improvement of immunity. VC can enhance immunity and anti-cancer ability.
As a free compound, 5- hydroxytryptamine can be used as a neurotransmitter, which plays an important role in regulating people's blood pressure, body temperature and internal environment, and also has anti-cancer effect.
Coumarin: It can enhance capillary function and stop bleeding.
Anthocyanin: It has anti-tumor effect.
Catechin: Enhance the effectiveness of radiation.
Picolin: Anti-tumor and Anti-radiation.
Phenolic compounds: have antioxidant effect.
5- hydroxylamine, catechin, bitter rosin, phenolic compounds, etc. It has the function of resisting strong radiation and can improve the tolerance of patients to radiotherapy and chemotherapy. Vitamins, α -tocopherol and unsaturated fatty acids can promote the growth and development of skin epithelial cells, repair cell and tissue damage, and thus promote the rehabilitation of tumor patients after surgery and radiotherapy and chemotherapy.
The authoritative medical institution designated by the Ministry of Health 18 experiments show that Hippophae rhamnoides oil has a significant inhibitory effect on tumors.
The functional test results of authoritative medical institutions designated by the Ministry of Health show that Hippophae rhamnoides oil has obvious effects of inhibiting tumors and regulating blood lipids. Its anti-tumor effect is mainly manifested in the following four aspects:
1, inhibit tumor spread 2, and directly kill cancer cells.
3, blocking carcinogenic factors 4, improving the body's immunity
Seabuckthorn oil, as a functional health food for adjuvant treatment of tumor, can improve the immunity of cancer patients, quickly eliminate the side effects caused by alopecia, anorexia and radiotherapy and chemotherapy, promote tissue recovery after surgery and radiotherapy and chemotherapy, improve sleep, increase appetite, relieve mental pain of cancer patients and help patients recover as soon as possible.
Medical research and clinical verification by domestic seabuckthorn medical experts and oncologists show that seabuckthorn oil has the following functions in tumor prevention and treatment:
◆ Prevention: activate normal cell vitality and block carcinogenic factors.
◆ Anti-cancer: directly kill cancer cells and induce cancer cells to commit suicide.
◆ Tumor inhibition: eliminate tiny cancer focus and inhibit tumor spread.
◆ For patients undergoing surgery, radiotherapy and chemotherapy, it can improve the tolerance of the body, eliminate the side effects of radiotherapy and chemotherapy, enhance the immunity of the body after treatment, and promote the repair of damaged tissues and the recovery of the body.
◆ Those who cannot undergo surgery or radiotherapy and chemotherapy for special reasons can improve immunity, control or relieve pain and prolong survival.
◆ As a functional health food for adjuvant treatment of tumors, it can make up for the shortcomings of various treatment methods and consolidate the curative effect. Especially for digestive system cancer, the effect is better.
◆ Treat all kinds of acute radiation dermatitis and mucositis.
◆ Repair cell damage and promote the recovery of damaged tissues.
◆ Quickly eliminate alopecia, anorexia and other symptoms caused by radiotherapy and chemotherapy.
Improve the immunity of patients with radiotherapy and chemotherapy
Anti-cancer is the hardest hand-to-hand combat that human beings have ever had with the same disease. Humans have used chemotherapy, radiotherapy and even "desperate" means to resist, but all kinds of powerful chemotherapy drugs and large doses of radiation have caused great harm to the patient's body while killing cells, resulting in many complications and sequelae. What is even more worrying is that many chemical drugs have strong immunosuppression, and radiotherapy will also lead to leukopenia and weakened immune function, thus causing great damage to the immune system of patients.
The biggest risk of cancer patients after surgery and radiotherapy and chemotherapy is the recurrence and metastasis of cancer cells. Because the immune function is destroyed, it is in a low state, and it is impossible to kill the cancer cells left after treatment, and it is even more impossible to inhibit their division and proliferation, which provides an opportunity for the rapid resurrection and proliferation of the remaining cancer cells, leading to tumor recurrence and metastasis, and the consequences are unimaginable.
Medical experiments show that seabuckthorn oil can improve the immunity of immunocompromised organisms, and its rich vitamins, carotenoids, trace elements, polyphenols and flavonoids can activate macrophages, activate T lymphocytes, increase the ability of cells to produce antibodies, produce a large number of interferons, restore the level of natural killer cells (NK) under immunosuppression, increase the content of interleukin -2 (ZL-2), and affect its gene expression. Through the above ways, seabuckthorn oil will achieve a significant effect of improving the immune function of patients undergoing radiotherapy and chemotherapy.
In addition, 5- hydroxytryptamine, coumarin and isocoumarin in seabuckthorn oil are components with comprehensive anti-cancer effects, which can directly kill or inhibit the division and proliferation of residual cancer cells, so as to avoid the recurrence of cancer cells caused by low immune function after radiotherapy and chemotherapy to the greatest extent, make up for the shortcomings of surgery and radiotherapy and chemotherapy, and achieve a consolidated therapeutic effect. Prevent tumor recurrence and promote postoperative rehabilitation.
Promote the rehabilitation of postoperative and radiotherapy and chemotherapy patients.
With the increasing application of radiotherapy and chemotherapy for malignant tumors, complications and sequelae are common, and there are few effective treatment methods in the past, and the effect is not ideal. Some patients have been cured for a long time and suffered a lot.
In the process of surgical treatment, in order to completely eliminate cancer cells, it is often necessary to remove the whole organ and part of the surrounding tissue at the focus, thus causing disability or deformity of the body and affecting some functions of the body.
In the process of radiotherapy, it is easy to cause acute radiation injury of skin and mucosa, abdominal distension, vomiting, indigestion, radiation cystitis and normal tissue damage.
Chemotherapy: Anti-cancer drugs are all drugs with high toxicity and low safety factor, which have certain damage to some cells such as bone marrow, lymphatic system, gastrointestinal epithelium, skin germinal epithelial cells and embryonic tissue.
At the same time, chemotherapy can cause: 1 local tissue necrosis, leukopenia, digestive tract reaction, urinary system reaction, liver injury, heart damage, brain toxicity, neurotoxicity, alopecia, kloc-0/0 immunosuppression.
Seabuckthorn oil can restore the immunity of patients after surgery, radiotherapy and chemotherapy, kill and inhibit residual cancer cells and avoid their recurrence and metastasis. In the early stage of cancer, it can directly kill cancer cells, inhibit the spread, and provide conditions for surgery, radiotherapy and chemotherapy, even without treatment. In the medium term, it can assist radiotherapy and chemotherapy, consolidate the curative effect and promote the rehabilitation of patients undergoing surgery and radiotherapy and chemotherapy.
Main anti-cancer and anti-tumor ways of seabuckthorn oil
1 Suppressed the spread of tumor and fought a beautiful battle of annihilation.
The high mortality rate of malignant tumor is caused by the spread and metastasis of cancer cells. Therefore, only by controlling the metastasis to the maximum extent and blocking its metastasis route can the risk of malignant tumor be minimized.
The inhibitory effect of seabuckthorn oil on tumor proliferation is mainly achieved through collagen fibers. The effective components in seabuckthorn oil, especially the rich VA, are necessary for the synthesis of collagen fibers, which can promote the production of collagen and form a stable and strong network in the "blank area" between cells (the only way for cancer cells to metastasize), thus blocking the metastasis of cancer cells. Collagen fibers can also actively wrap tumors, prevent them from spreading, make them atrophic tumors with very slow proliferation, lose infiltration of surrounding tissues, and then kill "rebellious" cancer cells through the immune system.
Hyaluronic acid is a substance secreted by cancer cells, which can destroy collagen fibers and play an important role in tumor metastasis and invasion. The effective components in seabuckthorn oil can stimulate normal cells to produce a substance that inhibits hyaluronic acid, thus weakening the destructive power of tumors and realizing tumor wrapping and panic attack.
Killing cancer cells directly destroys the "rebels".
In the process of cancer cell formation and proliferation, the human immune system has been fighting cancer-preventing cancer cell formation and killing cancer cells and mutant cells. The anti-tumor effect of seabuckthorn oil is not only blocking, but also inhibiting and even killing cancer cells directly through the immune system.
It has been confirmed by medical research that the effective components in seabuckthorn oil (including the newly discovered new generation of comprehensive anticancer components such as coumarin, bitter rosin and 5- hydroxy gum) have direct killing effects on cancer cells such as sarcoma, melanoma, lymphocytes, leukemia and gastric cancer.
3 block carcinogenic factors, nip in the bud
The main way of seabuckthorn oil to inhibit tumor is to block carcinogens and prevent cancer. The main performance is that the effective components of seabuckthorn oil can improve the immune function of the body and block strong carcinogens.
Seabuckthorn oil can improve the level of cyclic adenosine monophosphate in cells, promote cell maturation, prevent canceration, prevent carcinogens from combining with cells, inhibit the generation of free radicals, have a powerful scavenging effect on the free radicals that have already occurred, inhibit the process of pre-carcinogens activating into strong carcinogens, and eliminate the attachment of chemical carcinogens such as benzopyrene, N- nitroso compounds and aflatoxin on the cell surface.
4 induce cancer cells to commit suicide
There is a protein molecule "53" in cancer cells, which is responsible for transmitting suicide information to cells. It can be attached to the gene chip of cancer cells. Seabuckthorn oil can produce a large number of protein named "95" on the surface of cancer cells. When "95" accumulates to a certain amount, it will send a message that the cell is about to "commit suicide" to protein molecule "53" which constitutes cancer cells through biochemical reaction, which will make the cell nucleus, cell membrane and cytoplasm contract together and eventually lead to cell death. In this process, "95" actually plays the role of transmitting suicide information of cancer cells, while "53" is equivalent to receiving suicide information every day. Therefore, seabuckthorn oil can promote cancer cells to produce "53" and realize cancer cell suicide.
5 activate normal cells
After cells become cancer cells, if the body does not have the conditions for growth and reproduction, it will die quickly and will not form cancer; On the contrary, if it is promoted in the body, it will continue to proliferate and gradually develop into cancerous lesions.
Cancer cells need much more energy to proliferate than normal cells, so increasing the vitality of normal cells, improving their ability to compete for nutrition with cancer cells and starving cancer cells are also important ways to inhibit tumors.
Seabuckthorn oil can promote the differentiation and maturation of normal cells, make their structure complete and their activity enhanced, thus ensuring that the structure and function of cell membrane are not infringed by free radicals, ensuring the integrity of cell, chromosome and gene structure, and repairing manipulated cells.
6. Improve the immune function of patients with radiotherapy and chemotherapy.
Radiochemotherapy is the most widely used treatment method at present, but it kills cancer cells and also causes great damage to normal cells, especially some active cells such as bone marrow, lymphatic system, gastrointestinal epithelium, germinal epithelial skin and embryonic tissue, heart, liver, lung and other organs, leaving many complications. The most important thing is that it weakens the immune function of patients. Once the operation is unsuccessful, cancer cells will take advantage of it and spread rapidly, with disastrous consequences.
The effective components in seabuckthorn oil can activate the phagocytosis of giant cells, activate T lymphocytes, increase the ability of white blood cells to produce antibodies, produce a lot of interferon, restore the NK level of natural killer cells under immunosuppression, scavenge free radicals in the body, inhibit lipid peroxidation, increase the content of interleukin -2, affect its gene expression, and thus improve the immune function of the body.
7. Promote the rehabilitation of patients with radiotherapy and chemotherapy.
Seabuckthorn oil can treat radiation injury and promote tissue repair, so it can treat acute dermatitis caused by radiotherapy and chemotherapy in tumor patients. Myositis has an unexpected effect on postoperative and rehabilitation of patients undergoing radiotherapy and chemotherapy. It can quickly eliminate hair loss, anorexia and other side effects caused by radiotherapy and chemotherapy, improve patients' mental state and accelerate rehabilitation.
8 concluding remarks
Recent data show that there are10.6 million new cancer cases and10.3 million deaths in China every year.
As the most terrible disease in people's minds, cancer is like a plague, which makes many people miserable and eventually loses their precious lives, which makes many families fragmented and makes many relatives unable to smile. No matter men, women, children, rich or poor, no one can avoid it. One day, the disease will fall from the sky, and the long road of life will end in suffering. And what we can do is that prevention is better than cure!
In the century-long anti-cancer struggle, people finally saw a ray of light through the long night, and found a natural drug that can effectively control tumors and inhibit cancer, which is seabuckthorn oil.
Seabuckthorn oil, as a precious natural medicinal vegetable oil, provides a powerful weapon for human beings to conquer tumors with its unique and efficient anti-tumor and immune-enhancing active components, so that people can overcome and eliminate tumors with incomparable confidence and ability when facing diseases!