Yang Yan
gender
woman
date of birth
1964. 10
Tutor qualification
Doctoral supervisor/tutor
professional title
professor
postal service
Official academic certificate
doctor
Graduation time
1999.7
Highest degree
doctor
Grant time
1999.7 2009.4-2009.438+02 Postdoctoral research at the University of Queensland, Australia.
2006.8-2009.3 postdoctoral fellow in dermatology, Anhui Medical University
2004. 10-2005. 10 senior visiting scholar/postdoctoral fellow, kansai medical university, Japan
1995.9- 1999.7 Doctor of Pharmacology, Anhui Medical University
1989.9- 1993.7 Master of Pathophysiology, Anhui Medical University.
1981.9-1986.7 Anhui Medical University Bachelor of Medicine 2003. 1 1~ Professor/doctoral supervisor/doctoral supervisor of the Department of Pharmacology, Anhui Medical University
2009.4-2009.438+02 Postdoctoral fellow, University of Queensland, Australia
2006.8-2009.3 postdoctoral fellow in dermatology, Anhui Medical University
2004. 10-2005. 10 senior visiting scholar/postdoctoral fellow, kansai medical university, Japan
1999.12-2003.11Associate Professor/Master Supervisor, Department of Anti-inflammatory and Immunopharmacology, Anyi University? professor
1998.12-1999.11Associate Professor, Department of Immunology, Anhui Medical University.
1992.11-kloc-0/998.11lecturer, Department of Pathophysiology, Anhui Medical University? associate professor
1 986.7-1992.11Assistant Professor, Department of Pathophysiology, Anhui Medical University1. TGF-β/Smad Signal Transduction and MAPK Pathway Regulation Mechanism of Compound Qishen Extract Against Hepatic Fibrosis-Hepatocellular Carcinoma (8 1073098), a General Project of National Natural Foundation of China.
2. Molecular pathogenesis of keloid in Smad2/3 signaling pathway under 2.MAPK pathway KJ2008A30ZC was supported by the Natural Science Foundation of Anhui Provincial Department of Education (key project) in 2008.1-2010.1250,000.
3. TGF-b signal transduction mechanism of anti-fibrosis effect of compound Astragalus extract (2008Z027) Anhui Talent Fund 2008438+0-20438+00.438+0.24 million.
4. The role of Smad2/3 signaling pathway regulated by 4.MAPK pathway in the pathogenesis of keloid. Anhui postdoctoral fund 2008.438+0-2009.33 million.
5. The mechanism of compound Astragalus extract against hepatic fibrosis through TGF-b signal transduction pathway. No.24 [2007] China Ministry of Education Research Start-up Fund for Returned Overseas Students 2007.05438+0-201225,000.
6. Therapeutic Effect of Compound Astragalus Extract on Keloid and Its TGF-b Signal Transduction Mechanism (2006007 16) China Postdoctoral Science Foundation 2006.01-2009.1230000.
7. Pharmacodynamics in Liver Diseases and Liver Surgery (ID 5697 10) Australian National Institute of Health and Medicine (NHRMC) Fund 2009.01-201.1.22 million Australian dollars (participated in Queensland in 2009,
Published papers (20/200712)
1. He S, Yang Y*, Liu X, Huang W, Zhang X, Yang S, Zhang X. Compound Radix Astragali and Radix Salviae Miltiorrhizae extract inhibits cell proliferation, invasion and collagen synthesis of keloid fibroblasts by mediating transforming growth factor -β/Smad pathway. Br J Dermatol，20 12， 166(3):564-74。
2. He Sheng, Liu, Yang, Huang, Xu, Yang, Zhang, Zhang. Mechanism of transforming growth factor β/Smad signal transduction mediated by mitogen-activated protein kinase pathway in keloid fibroblasts. Br J Dermatol，20 10， 162(3): 538-46。
3. Liu X, Yang Y*, Zhang X, Xu S, He S, Huang W, Roberts MS Compound Radix Astragali and Radix Salviae Miltiorrhizae extract inhibits cell invasion by regulating the transforming growth factor -β/Smad of HepG2 cells. Journal of Gastrointestinal Hepatology, 20 10.25(2):420-6.
4. Compound Radix Astragali and Radix Salviae Miltiorrhizae extract plays an anti-fibrosis role by mediating TGF-β/Smad signaling pathway in myofibroblasts. J ethnopharmacology, 2008. 1 18(2):264-70.
5. Zou, Yan Yang *, Li Jun, Wu Qing, Li Weiping, Lu Jiantang and Roberts. What is the potential therapeutic effect of JN on the liver? Carbon tetrachloride induced bone fracture in rats. Journal of ethnopharmacology. 2008. 120(3): 452-7.
6. Liu X, Zou, Heranzos AM, Yang Y, Nikolovski J, Weiss M and
After the initial dose of propranolol in perfused rat liver, the sinus relaxation induced by nitric oxide decreased the utilization rate of propranolol in subsequent administration. Clin。 Exp。 Pharmacology. Physiologist. 20 10.37: 1028-33
7. Rui, He, Huang Xianjia, Hang Xin, Li Qianjin, Yang Yan *. Expression of pSmad3L and PAI- 1 protein in *-induced hepatic fibrosis-hepatocellular carcinoma. Mouse nest. Bulletin of Pharmacology of China. 20 12; 28: 1393-7
8. Huang Weijuan, He, Yan Yang *, Zhou Fusheng, Fang, Yang Sen,. Effect of compound Qishen extract on Smad protein connection of keloid fibroblasts. Journal of Anhui Medical University, 20 10.45(6):780-4.
9. Liu, Xiao Bingkun, Yang, Yang Yan, Huang. Research progress on antitumor mechanism of toosendanin. Science, technology and engineering, 2011; 1 1(2): 167 1- 18 15
10. Yang Lin, Wang Lin, Yan Yang, Zhang Shouguo, Jing Liu, Peng Tao, Wen Xiaoxue, Yu Haiyan. Synthesis of anti-tumor drug PD 168393, Journal of Pharmacy of PLA, 2010; 26(3):0 192-03
1 1. Fang Jia; He Fang Shu; Yang Lin; Zou Yuhong; Wu Yingying; Yang Yan *. Inhibitory effect of anti-liver cirrhosis compound on proliferation and collagen synthesis of stellate cells in vitro. Journal of Anhui Medical University. 2008.43 (2): 0 169-04。
12. He, Huang Weijuan, Yang Yan *, Zhou Fusheng, Fang, Yang Sen,. The expression of PAI- 1 mRNA in keloid fibroblasts induced by TGF-b 1 was detected by real-time quantitative RT-PCR. Bulletin of Pharmacology of China, 2009.
13. He,,,,, Yang Yan *, Zhang Xuejun. Effects of effective fraction of Astragalus membranaceus on proliferation, migration and phosphorylation of Smads protein in rat myofibroblasts. Bulletin of Pharmacology of China, 2008.24 (7): 421-4.1. 54666.86666666666
2.20 1 1 won the second prize of multimedia courseware in Anhui province.
3.20 1 1 won the third excellent master's thesis (tutor) in Anhui Province.
4.20 10 won the 11th Anhui Youth Science and Technology Award.
5.20 10 won the excellent postgraduate tutor of Anhui Medical University.
6. In 2005, it was approved to enjoy the government allowance of the State Council.
7.200 1 year won the Young Pharmacologist Award of Chinese Pharmacology Society.
8. In 2000, he won the first prize of Anhui Natural Science (ranked second).
9. Patent: Effective parts of Astragalus membranaceus, preparation method and its application in pharmacy (ranked sixth); In 2003, "Astragaloside IV" obtained the clinical approval of 1999, and has trained 14 graduate students since 2000. At present, four graduate students are studying. One doctor graduated and there are currently three doctors studying.