In 1866, Dr. John Langdon Down first described and published the typical signs of Down syndrome, including similar facial features of such children. Therefore, this syndrome is named down syndrome after its name.
Extended data:
Preventive strategy
1, genetic counseling
The older the pregnant woman, the higher the risk rate. The recurrence risk rate of standard Down syndrome is 65438 0%. Parents of children with translocation should carry out karyotype analysis in order to find balanced translocation carriers: if the mother is D/G translocation, the risk rate of each fetus is10%; If the father is D/G translocation, the risk rate is 4%.
2. Prenatal diagnosis
Prenatal diagnosis is an effective measure to prevent the birth of children with Down syndrome. Couples who have a history of bearing this disease should make prenatal diagnosis, that is, chromosome karyotype analysis. Sampling includes amniocentesis of amniotic fluid cells in the second trimester, chorionic villi cells in the second trimester and umbilical cord blood lymphocytes in the second trimester.
The determination of serum markers HCG and AFP in prenatal screening has certain clinical significance, because it can reduce the blindness of prenatal diagnosis of amniocentesis, prompt the existence of high-risk pregnant women, enable these pregnant women to do further prenatal examination and consultation, and prevent the birth of children with Down syndrome to the greatest extent.
Baidu Encyclopedia-Down Syndrome in Children