Product introduction of febuxostat tablets (Fengdingning)
Febustat tablets (Fengdingning)
Generic name: febuxostat tablets
Manufacturer: Hangzhou Zhuyangxin Pharmaceutical Co., Ltd.
Approval number: National Medicine Zhunzi H20 130009
Drug specification: 40mg* 12 tablets.
Instructions for febuxostat Tablets (Fengdingning)
Generic name febuxostat tablets
Product name: febuxostat tablets (Fengdingning)
English name FebuxostatTablets
Pinyin full code FengDingNingFeiBuSiTaPian
The main component of febuxostat tablets is febuxostat, and its chemical name is 2-[(3- cyano -4- isobutoxy) phenyl ]-4- methyl -5- thiazolecarboxylic acid.
Molecular formula: c16h16n2o3 s.
Molecular weight: 3 16.37
Properties: Fengding Ning Fei Busotan tablets are white tablets.
Indications/Functions: Fengding Ning Fei Busotan Tablets are xanthine oxidase (XO) inhibitors, which are suitable for long-term treatment of hyperuricemia with gout symptoms.
Specification 40mg* 12 capsules
Usage and Dosage It is suggested that the dosage of Fengding Ning Fei Busotan Tablets should be 40mg or 80mg once a day.
Adverse reactions: weakness, chest pain/discomfort, edema, fatigue, abnormal mood, gait disorder, flu symptoms, nausea, pain and thirst.
Contraindications Patients who are taking azathioprine, thiopurine or choline are prohibited from using Fengding Ning Fei Bustatista Tablets.
Note: 1. After starting treatment with Fengding Ning Fei Busotan tablets, an increase in gout attacks can be observed. This is due to the change of serum uric acid level, which leads to the deposition of urate activity. In order to prevent gout attack when taking Fengding Ning Fei Busotan tablets, it is suggested to take non-steroidal anti-inflammatory drugs or colchicine at the same time. 2. In the randomized controlled study, patients who used Fengding Ning Fei Busotan Tablets [0.74 per100 p-y (95% ci 0.36-1.37)] were more likely to receive allopurinol [0.60 per100 p-y (95%). Signs and symptoms of myocardial infarction (MI) and stroke should be monitored. 3. In the randomized controlled study, it was observed that the level of transaminase was more than 3 times higher than the normal upper limit (patients who were given Fengding Ning Fei Busotan tablets and allopurinol increased respectively, AST: 2%, 2%, ALT: 3%, 2%). No dose-effect relationship was found with the increase of transaminase. Laboratory analysis of liver function suggested that Fengding Ning Fei Busotan tablets should be used for treatment in February and April, and then treated regularly.
The safety and efficacy of Fengding Ning Fei Busotan Tablets in children under 18 years old have not been determined.
Elderly patients need not adjust the dosage when using Fengdingning Febustat tablets. Compared with other age groups, there is no obvious clinical difference in safety and effectiveness, but it does not rule out that some elderly patients are more sensitive to Fengding Ning Fei Busotan tablets. Elderly patients (? Cmax and AUC24 of 65-year-old patients after taking febuxostat for many times are similar to those of young patients (18-40 years old).
For pregnant and lactating women 1. During organogenesis, rats and rabbits took febuxostat orally at a dose of 48 mg/kg (40 times and 50 times that of humans at a dose of 80 mg/day, respectively), and there was no teratogenic effect. During organogenesis and lactation, pregnant rats were given oral Fengding Ning Fei Busotan tablets at a dose of 48mg/kg (40 times that of 80mg/ day). It was found that neonatal mortality increased and neonatal weight increased. 2.Non-buzostat is secreted by the milk of rats. It is not clear whether febuxostat is secreted by human milk. Because many drugs are secreted by human milk, it is necessary to be cautious when giving Fengdingning Febusotan tablets to lactating women.
Drug interaction febuxostat is a xanthine oxidase (XO) inhibitor. Although the interaction between Fengding Ning Fei Busotan tablets and drugs metabolized by XO (such as cholophylline, thiopurine and azathioprine) has not been studied, the inhibitory effect of Fengding Ning Fei Busotan tablets on XO will increase the plasma concentration of these drugs and produce toxicity. Patients who are taking azathioprine, thiopurine or choline are prohibited from using Fengding Ning Fei Busotan Tablets.
After drug overdose, the dosage of Fengding Ning Fei Bustatista tablets reached 300mg for 7 consecutive days, and there was no dose-limiting toxicity. No cases of drug overdose were reported. Patients with drug overdose should receive symptomatic and supportive treatment.
Pharmacology and Toxicology Febuzostat is an inhibitor of xanthine oxidase, which can achieve therapeutic effect by reducing serum uric acid.
In the pharmacokinetics of healthy volunteers, Cmax and AUC increased in a dose-dependent manner after single or multiple doses of febuxostat 10 mg ~ 120 mg were taken. When the therapeutic dose was administered every 24 hours, no cumulative effect was observed. The average terminal elimination half-life (t 1/2) of febuxostat is about 5 ~ 8 hours.
Storage seal.
Packaging 40mg* 12 tablets/box.
Valid for 24 months.
Approval number: National Medicine Zhunzi H20 130009
Hangzhou zhuyang new pharmaceutical co., ltd.
Efficacy and role of febuxostat tablets (Fengdingning) This product is an inhibitor of xanthine oxidase (XO) and is suitable for long-term treatment of hyperuricemia with gout symptoms.
Frequently asked questions about taking febuxostat tablets (Fengdingning)
Q: Tongfengding tablets have the effect of promoting blood circulation, dredging collaterals and relieving pain. Each drug has its own matters, such as efficacy, applicable population, usage and dosage and other precautions, and Tongfengding tablets are no exception. So, who are the suitable people for gout tablets?
A: Tongfengding tablets are suitable for patients with gouty arthritis, joint deformity, gouty stones, liver injury, kidney calculi's disease, renal failure, heart disease, diabetes, hypertension and obesity. Can Tongfengding tablet effectively eliminate urate crystal deposition and tophi in joint cavity and subcutaneous tissue? Accelerate the dissolution and excretion of urate crystals, eliminate the causes of recurrent gout, and make tophi gradually shrink until it disappears. Tongfengding tablets are suitable for joint swelling and pain caused by damp heat, accompanied by fever, sweating, thirst and polydipsia, upset, yellow urine and gout.