1.？ Different design concepts
The design concept of the space shuttle is reusable, while the spacecraft is disposable.
2.？ There are also great differences in structure and appearance.
The structure of the space shuttle is similar to that of an airplane, which is a wing structure, while the spacecraft is composed of multiple cabins. These differences make them behave differently when launching, running and returning to Earth.
3.？ The difference between cost and technical difficulty
The space shuttle consists of many parts, including orbiter, solid rocket booster and external fuel tank. The technical requirements of the space shuttle are very high, involving many complex technologies and systems, such as rocket engine, flight control system, material science and so on.