The first batch of patients responded well. Www.ufo- 1.cn wonders.
In April this year, 19 patients with liver cancer who received chemotherapy but did not get better began to take this new drug called ALN-VSP. Within a few weeks after taking the first dose of the drug, the drug obviously began to prevent the tumor from producing the protein needed for its own growth.
By June this year, arni Ram claimed that ALN-VSP had successfully cut off 62% of the blood flow of liver cancer patients by "awakening" a rarely used immune defense system. In the treatment of liver cancer, traditional drugs generally adopt the method of eliminating pathogenic proteins, while ALN-VSP directly prevents cells from producing pathogenic proteins through RNA interference (RNAi) therapy.
Awaken the body's own defense mechanism
Scientists have also discovered the wonderful connection between ribonucleic acid (RNA) and deoxyribonucleic acid (DNA)-if DNA is protein's drawing, then RNA is a builder who can give instructions. RNA copies genes in DNA into single-stranded messenger RNA, transmits information to cells, and then produces protein.
1998, scientists discovered the mechanism of RNA interference (RNAi). Primitive organisms used this system to identify and destroy virus double-stranded RNA and virus messenger RNA. The researchers found that introducing a short piece of double-stranded RNA into cells can trigger this ancient mechanism buried in human body, and make RNAi stop producing specific protein again.
From this perspective, it can be said that RNAi has the ability to cure many diseases, including cancer. The characteristics of these diseases are generally caused by excessive common proteins produced by diseased cells. Theoretically, it is not difficult to manipulate RNAi to kill protein. For example, ALN-VSP contains synthetic double-stranded RNA, which matches the messenger RNA used in liver tumors and encodes two kinds of protein, namely, vascular endothelial growth factor (VEGF) which promotes tumor blood vessel growth and spindle driver protein (KSP) which accelerates tumor cell division.
After the synthesized double-stranded RNA enters hepatocytes, the RNAi mechanism in human body will destroy the synthesized RNA and any messenger RNA related to tumor growth, and prevent the continuous production of protein, thus preventing tumor growth.
It is expected to "cure all diseases"
In addition to its application in the field of cancer, this technology that can attack a single gene has also set off a whirlwind of RNAi treatment in other medical fields. At present, arni Ram has applied this therapy to the research of Huntington's disease, macular degeneration, muscular atrophy and AIDS.
John rossi, a well-known molecular geneticist in California, said that RNAi therapy is expected to mature within two years. Due to the good results of the first batch of experiments, ALN-VSP is expected to be the first drug to be marketed based on RNAi theory. Rossi said: "I think RNAi therapy is effective for all diseases." According to the China Journal.
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