[pharmacology]
pharmacodynamics
Clinical and experimental studies show that dipyridamole has antithrombotic effect. Dipyridamole inhibited platelet aggregation in the first and second stages; High concentration (50μ g/ml) can inhibit platelet release induced by collagen, epinephrine and thrombin. The mechanism is as follows: ① Reversible inhibition of phosphodiesterase can increase cAMP in platelets; ② It can enhance PGI2 activity and activate platelet adenylate cyclase; ③ Thromboxane A2(TXA2) function was slightly inhibited.
pharmacokinetics
Oral absorption is rapid. After entering the body, it is combined with glucuronic acid in the liver, discharged into bile, and absorbed into the blood after entering the small intestine, so the effect is more lasting. The blood concentration fluctuates greatly, and the half-life in blood is only 2 ~ 3 hours. Normal people take 200mg orally every day, and the blood concentration fluctuates between 1.8 ~ 5.6 μ mol/L, with little urine excretion.
[Drug Interaction]
When (1) is used together with aspirin, the dosage of dipyridamole should not exceed 100mg/ day, or 1g/ day if aspirin is taken orally.
(2) If this product is used together with heparin, coumarins, cefamandole, cefotetan, procaine or valproic acid, it may aggravate hypercoagulability 1 proton pump disease or further inhibit platelet aggregation, which may cause bleeding, so it is necessary to strengthen observation.
manufacturer
Kaifeng Pharmaceutical Factory, Jiangsu Wuzhong Industrial Co., Ltd. Suzhou No.6 Pharmaceutical Factory, Dandong Yichuang Pharmaceutical Co., Ltd., Guangdong Nanguo Pharmaceutical Co., Ltd., Shanghai Tian Ping Pharmaceutical Co., Ltd., Yunnan Dehong mangshi Pharmaceutical Factory, Chengdu Pharmaceutical Co., Ltd., Zhanjiang Xiangyang Pharmaceutical Factory, Guangzhou Pharmaceutical Company Guangzhou Mingxing Pharmaceutical Factory, Guangzhou Military Region Junshan Pharmaceutical Factory, Henan Xinxiang Huaxing Pharmaceutical Factory, Jiangxi Sinopharm Co., Ltd., Henan Pingyuan Pharmaceutical Factory, shandong jintai Group Co., Ltd. Jinan Jinda Pharmaceutical Co., Ltd., shandong jintai Pharmaceutical Factory, Shandong Dezhou Pharmaceutical Group Yanling Pharmaceutical Factory, Shandong Jining Second Pharmaceutical Factory, Xiamen Second Pharmaceutical Factory, Zhejiang Jiangnan Pharmaceutical Factory, Hefei Fourth Pharmaceutical Factory, Anhui Bengbu Second Pharmaceutical Factory, Anhui Hualian Pharmaceutical Co., Ltd., Nantong Shenyi Pharmaceutical Co., Ltd., jianhu county Pharmaceutical Factory, Kunshan Shuanghe Pharmaceutical Co., Ltd., Shanghai Hefeng Pharmaceutical Co., Ltd., Shanghai Sixth Pharmaceutical Factory, Shanghai Jiufu Pharmaceutical Company Zhao Xiang Company, Panjin Biochemical Pharmaceutical Factory, Harbin No.4 Pharmaceutical Factory, Mudanjiang Oriental Pharmaceutical Co., Ltd., Dalian Jinyi Pharmaceutical Factory, Linfen Jianmin Pharmaceutical Factory, Tongliao Pharmaceutical Factory, Shenyang Hongqi Pharmaceutical Factory of Northeast Pharmaceutical Group, Shanxi Pharmaceutical Research Institute Experimental Pharmaceutical Factory, Beijing Great Wall Pharmaceutical Factory, Shijiazhuang Hualong Pharmaceutical Co., Ltd., Hebei Sanjiu Taihang Pharmaceutical Co., Ltd., Shijiazhuang Xinhua Pharmaceutical Factory, Hebei Medical University Pharmaceutical Factory, and Hebei Xinxing Pharmaceutical Factory.