Ketoconazole is a pyrrole antifungal agent. It has antibacterial and bactericidal effects on dermatophytes, yeasts (candida, pityrosporum, coccidia and cryptococcus), biphasic fungi and fungi; In addition to entomophilous bacteria, it has a weak effect on Aspergillus, Sporothrix schenckii, some black spore families and Mucor.
The main mechanism of ketoconazole is highly selective interference with the activity of fungal cytochrome P-450, thus inhibiting ergosterol biosynthesis on fungal cell membrane.
Compound ketoconazole cream is mainly used for superficial fungal infections of the skin, such as tinea manus, tinea pedis, tinea corporis and tinea cruris, but it should be prohibited under the following circumstances:
It is forbidden for those who are allergic to the ingredients of this product, other pyrroles, aminoglycosides and corticosteroids; Viral infections such as herpes and chickenpox are forbidden.
In addition, pregnant women and lactating women use drugs:
1. Pregnant women should weigh the pros and cons and use it with caution. Long-term, large-scale or large-scale use of this product is prohibited.
2. Lactating women should use it carefully after weighing the pros and cons.
In short, pregnant women and lactating women are prohibited.
Therefore, the drug mainly has the following adverse reactions:
1. There are occasional allergic reactions locally, such as burning sensation, erythema, itching, tingling, etc.
2. Skin atrophy, telangiectasia, pigmentation and secondary infection may occur after long-term use.
3. It can be seen that the skin is dry, hairy, shriveled and susceptible to infection.
4. Long-term medication may cause hypercortisolism, manifested as hirsutism, acne, full moon face, osteoporosis and other symptoms.
5. Occasionally it may cause allergic contact dermatitis.