Lipitor is still the best-selling drug in the world in 2009, with total annual global sales of $654.38+0.23 billion, including $654.38+065.438+0.2 billion in the US market and $654.38+065.438+0.2 billion in other countries. Although Lipitor's sales in the US market declined last year, its sales in other countries and regions in the world increased, thus offsetting the decline in its total sales.
The therapeutic effect of atorvastatin calcium tablets is quite good. If you need to buy atorvastatin calcium tablets, welcome to 1 drug online pharmacy to ensure authenticity, favorable price and convenient purchase.
Atorvastatin calcium tablets, as a good lipid-lowering drug, belong to the first-line drug for lowering cholesterol. Oral absorption is good. Due to extensive metabolism in the liver, the absolute bioavailability is low, about 12%. This product is metabolized into various active metabolites by cytochrome P4503A4 in the liver. The average plasma half-life of atorvastatin is about 14 hours, but due to the influence of its active metabolites, the actual half-life of its inhibitory effect on HMG-CoA reductase is 20 ~ 30 hours. The protein binding rate of atorvastatin calcium tablets is 98%, and most of them are excreted in bile as metabolites.