2) Long-term high-dose use can continuously reduce the acidity of gastric juice, which is beneficial to the reproduction of bacteria in the stomach, thus reducing nitrate in food to nitrite and forming N- nitroso compounds.
Compound ranitidine capsules
standard light sources
Drug name
Generic name: CompoundRanitidineCapsules Previous name: trade name: English name: compound ranitidine capsules Chinese pinyin: compound ranitidine capsules The main ingredients of this product are ranitidine hydrochloride and bismuth potassium citrate.
composition
Character; Role; letter
This product is a capsule, and its contents are light yellow particles or powder.
Functional category
Pharmacology and toxicology
Ranitidine is an H2 receptor blocker, which can effectively inhibit gastric acid secretion and reduce pepsin activity. Potassium bismuth citrate can disintegrate rapidly in the stomach. Under the action of gastric acid, water-soluble colloidal bismuth forms insoluble bismuth-containing precipitate with protein on the ulcer surface or inflammatory site, and firmly adheres to the rotten surface, forming a protective barrier to resist the erosion of gastric acid and pepsin on the mucosal surface. It can also stimulate endogenous prostaglandin release, promote gastric mucus secretion, accelerate mucosal epithelial repair, improve gastric mucosal blood flow and eliminate Helicobacter pylori.
pharmacokinetics
Ranitidine is absorbed quickly and has obvious first-pass effect. Most drugs are excreted in the original form, and a small amount of metabolites are excreted by the kidney and excreted by the bile. Potassium bismuth citrate is rarely absorbed, with the highest bismuth concentration in kidney and a small amount in lung, spleen, liver, brain, heart and skeletal muscle. Absorbed products are excreted through urine, while unabsorbed products are excreted through feces.
indicate
Gastric ulcer, duodenal ulcer and helicobacter pylori infection.
dosage
Oral, adults each time 1 capsule, twice a day. The course of treatment should not exceed 6 weeks. The dosage and course of treatment of combined antibiotics are in accordance with the doctor's advice.
counteraction
(1) There may be nausea, rash, constipation, fatigue, headache, dizziness and insomnia. The tongue coating is black and grayish brown, and will disappear after stopping taking medicine. (2) ALT, AST and serum creatinine increased slightly in a few patients. (3) Mental states such as disorientation, lethargy and anxiety occasionally appear after taking the medicine.
taboo
Allergic to ranitidine bismuth citrate or any other ingredients, severely renal insufficiency and pregnant women are prohibited.
Matters needing attention
(1) In general, patients with hepatic and renal insufficiency should be appropriately reduced or used with caution. (2) Long-term high-dose use can continuously reduce the acidity of gastric juice, which is beneficial to the reproduction of bacteria in the stomach, thus reducing nitrate in food to nitrite and forming N- nitroso compounds.
Medication for pregnant and lactating women
Use with caution for lactating women.
Children's medication
Not recommended for children.
Medication for elderly patients
It's not clear yet.
drug interaction
It's not clear yet.
excessive
standard
Each capsule contains ranitidine (calculated by C 13H22N4O3S) 100mg, and bismuth potassium citrate (calculated by Bi) 1 10mg.
store
Keep away from light, seal and store in a cool and dry place.
parcel
term of validity
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Ranitidine hydrochloride tablets
Category of Action This product is an over-the-counter drug for inhibiting gastric acid and protecting gastric mucosa.
Pharmacological action This product has a strong inhibitory effect on gastric acid secretion. It is quickly absorbed by gastrointestinal tract after oral administration.
Indications are used to relieve stomach pain, heartburn (heartburn) and gastric acid reflux caused by hyperacidity.
Administration and dosage: oral. Adults should take 1 tablet once twice a day. No more than 4 diapers in 24 hours.
Contraindications: those who have allergic history to this product, and those with hepatic and renal insufficiency are prohibited.
Note: This product should not be used continuously for more than 7 days. If the symptoms do not relieve or disappear, please consult a doctor or pharmacist. Children should use this product under the guidance of a doctor. Use with caution for elderly patients, pregnant women and lactating women. In case of overdose or serious adverse reactions, please seek medical attention immediately. It is forbidden to use drugs with changed properties. Children must use it under the supervision of adults. Please keep this medicine out of the reach of children.
Drug interaction combined with procainamide can reduce the clearance rate of procainamide. If you are taking other medicines, please consult a doctor or pharmacist before using this product.
Common adverse reactions include nausea, rash, constipation, fatigue, headache, dizziness and so on. The adverse reactions to renal function, gonadal function and central nervous system were lighter than those of cimetidine. A few patients have mild liver function damage after taking the medicine, and the symptoms disappear after stopping taking the medicine, and the liver function returns to normal.
Specification: 0.075g per tablet.
Standard Source Generic Drugs (Pharmacopoeia 2000 Edition)
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ranitidine
(History) This product, like cimetidine, is the most widely used drug to treat ulcers at present. Developed by GlaxoSmithKline, UK. 1976 was synthesized by British Price, its pharmacology was expounded by Bradshaw in 1979, and it was reported by Berstad in 1980 that it was effective for duodenal ulcer, and it was listed in 198 1, and it was in nearly 100 countries in the world. China 1985 is produced by Shanghai Sixth Pharmaceutical Factory.
Furnitramine (other name); Methanofuran guanidine; Wei Antai Ding; Good stomach; Ruined; ZantaacRannineSostril Ranidil
(Properties and stability) The hydrochloride of this product is white to yellowish crystalline powder; Especially smelly, slightly bitter, astringent, easily deliquescent, black after moisture absorption, soluble in water, soluble in methanol and slightly soluble in ethanol.
(In vivo process) It is absorbed quickly after oral administration, and its first-pass metabolism is obvious after oral administration. It is metabolized into inactive substances in the liver, and its bioavailability is about 50%, which is higher in patients with liver disease. The peak blood concentration can be reached within 2-3 hours. It is widely distributed in the body, the effective blood concentration can be maintained above 12 hours, and the plasma half-life of adults is 2-3 hours, which is prolonged for the elderly and patients with liver and kidney diseases. The complete rate of plasma protein was 65438 05%.
This product is mainly excreted in urine, and some drugs enter the biliary tract from bile and are excreted with feces. The product can be removed by dialysis.
(Drug action) This product is an antagonist of H2 receptor, which promotes ulcer healing by competitively inhibiting histamine H2 receptor. It is 4- 13 times stronger than cimetidine in resisting gastric acid secretion stimulated by pentagastrin, and its drug effect lasts for a long time. This product can inhibit the amount and concentration of gastric juice stimulated by night and food. There is little antiandrogen effect, so there is little male breast development. This product has no obvious inhibitory effect on liver drug enzymes.
(Indications) (1) is used to treat hyperacidity and gastritis. (2) It is suitable for many patients with peptic ulcer who are ineffective in the treatment of cimetidine and those who cannot tolerate cimetidine.
The incidence of (adverse reactions and precautions) is less than 3%. Common headache, dizziness, fatigue, constipation, rash, etc., can generally subside with continued treatment. Some patients have leukopenia or thrombocytopenia, or elevated transaminase, but they can recover after stopping taking the drug.
This product can be excreted from breast milk and should be used with caution by lactating women.
Pregnant women and children under 8 years old should be prohibited from using it.
Those who have a history of allergy to this product are prohibited from using it.
(Drug Interaction) (1) This product can reduce the absorption of diazepam in the body and reduce its blood concentration by 25%. If necessary, the interval should be at least 1 hour. (2) This product can reduce the hepatic blood flow, so when it is combined with drugs whose metabolism is greatly affected by hepatic blood flow, it can delay the onset time of these drugs and enhance their effects.
(Usage and dosage) Oral. Hyperacidity, adult 0. 15g once, twice a day; Or 0.3 grams a day, before going to bed.
For reflux esophagitis caused by gastric or duodenal ulcer, adults should take 0. 15g once, twice a day, after breakfast and before going to bed.
Maintenance therapy: 0. 1.5g daily, taken before going to bed, can inhibit gastric acid secretion at night and prevent ulcer recurrence. When the pain needs to be controlled, you can take antacids, but the interval should be at least 1 hour.
(Limited dosage form) Tablets and capsules.
Ranitidine: Capsule, produced by Shantou Jinshi Pharmaceutical Factory. 0. 15g per capsule, 30 capsules per bottle, taken orally, as above. Store in a closed, room temperature and dry place.
Ranitidine: Capsule, produced by Suzhou No.3 Pharmaceutical Factory. Each capsule contains 65438 050 mg of ranitidine hydrochloride. Oral, 1 capsule once, twice a day, maintenance amount of one day 1 capsule.
Sitas: tablets, produced by Guangzhou Nanxin Pharmaceutical Co., Ltd., each containing ranitidine hydrochloride 150mg. Oral, 1 tablet once, twice a day, maintenance amount of one day 1 tablet.
Blue: tablets, produced by Hangzhou Sanofi Minsheng Pharmaceutical Co., Ltd., each containing ranitidine hydrochloride 150mg. Oral, 1 tablet once, twice a day, maintenance amount of one day 1 tablet.
Shanweide: Tablets, produced by Glaxo Wellcome China Company. Each tablet contains ranitidine hydrochloride 150mg and 300mg, and each box contains 10 tablets. Usage as above. Store in a closed, room temperature and dry place.
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