Vinyl pyrrolidone polymer
Water-soluble polyamide
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polyvinylpyrrolidone
polyvinylpyrrolidone
Chinese name: polyvinylpyrrolidone
English name: polyvinylpyrrolidone
Si Nuo. : 9003-39-8
Molecular formula: CH4
Molecular weight: 16.4046
EINECSNo。 : 13 12995- 182-4
Mol file: 9003-39-8.mol
polyvinylpyrrolidone
Properties of polyvinylpyrrolidone
Melting point > 300℃
Boiling point 90-93℃
Density1.69g/cm3
Storage conditions 2-8℃
Solubility H2O: soluble 100 mg/ml.
Morphological powder
Colors range from white to yellowish white.
PH value 3.0-5.0
Soluble in water.
Sensitive hygroscopicity
Merck14,7697
Stable. Incompatible with strong oxidant. Photosensitive. Moisture absorbing.
(IARC) Carcinogen Classification 3 (Vol. 19, Sup71)1987.
EPA chemical information polyvinylpyrrolidone (9003-39-8)
Application and synthesis method of polyvinylpyrrolidone
PVP for short is a polymer of polyvinylpyrrolidone, which can be divided into soluble PVP and insoluble PVPP because of its different polymerization degree. The relative molecular weight of soluble PVP is 8000 ~ 10000, which can be used as a precipitant and will precipitate when it reacts with polyphenols. In this way, it is easy to leave PVP in wine. Because PVP can accumulate in the human body, the World Health Organization does not recommend the use of this substance. In recent years, the use of soluble PVP is rare. Insoluble PVPP system began to be used in beer industry in the early 1960s, and its relative molecular weight was more than 700,000. It is a polymer insoluble substance formed by further crosslinking polymerization of PVP, and can be used as an adsorbent for polyphenols with good effect.
Structural formula of polyvinylpyrrolidone
Structural formula of polyvinylpyrrolidone
PVP is one of the three new pharmaceutical excipients, which can be used as a cosolvent for tablets, granules and injections, a glidant for capsules, a dispersant for liquid preparations and colorants, a stabilizer for enzymes and heat-sensitive drugs, a precipitant for insoluble drugs, a detoxifier and lubricant for eye drops, etc.
Industrially used as foaming polystyrene additives, gelling agents, stabilizers, fiber treatment agents, paper processing additives, adhesives and suspension polymerization thickeners.
Polyvinylpyrrolidone PVP and its * * * polymer CAP are important raw materials of cosmetics, mainly used as hair retention agents. The film formed on the hair is elastic and shiny, with excellent combing performance and no dust. Resins of different specifications can meet all kinds of relative humidity and climate conditions, so they are indispensable raw materials for styling hair cream, hair gel and mousse. It can also be used as skin care humectant for cosmetics, hair dyeing dispersant and foam stabilizer for ointment matrix, and can improve the consistency of shampoo.
Insoluble PVP is a stabilizer for beer and fruit juice, which can improve its transparency, color and taste.
Water-soluble polyamide polyvinylpyrrolidone (PVP) is a water-soluble polyamide. According to the K value (Fikentscher K value), PVP in the market is divided into four viscosity grades: K- 15, K-30, K-60 and K-90, and their number-average relative molecular weights are 10000 and 40000, 160000 and 360000 respectively. K value or relative molecular weight is one of the important factors that determine the properties of PVP.
Polyvinylpyrrolidone (PVP) is soluble in water, chlorine-containing solvents, ethanol, amines, nitroalkanes and low molecular weight fatty acids, and in most inorganic salts and various resins. Insoluble in acetone, ether, etc. The polyvinylpyrrolidone used as the matrix of dropping pills is odorless and tasteless, white to yellowish waxy solid, with a relative density of 1.062 and a pH value of 3-7 in a 5% aqueous solution. PVP is hygroscopic. Good thermal stability, soluble in various organic solvents, high melting point. Adding some natural or synthetic polymers or organic compounds can effectively adjust the hygroscopicity and softness of PVP. Polyvinylpyrrolidone is not easy to react chemically, and dried PVP is very stable when stored under normal conditions. PVP has excellent physiological inertia and biocompatibility, and has no irritation to skin and eyes, no allergic reaction and no toxicity.
Due to hydrogen bonding or complexation, the viscosity of polyvinylpyrrolidone increases, which inhibits the formation and growth of drug crystal nucleus and makes the drug amorphous. Dropping pills based on polyvinylpyrrolidone (PVP) can improve the dissolution and bioavailability of poorly soluble drugs. Generally speaking, the greater the dosage of PVP, the greater the dissolution and solubility of drugs in the medium. Susana et al. studied the dissolution of the insoluble drug albendazole in PVP(k30) solid dispersion. With the increase of PVP(k30) dosage, the dissolution rate and efficiency of drug in solid dispersion increased. Teresa et al. studied the dissolution of PVP solid dispersion of flunarizine, and found that the higher the PVP content, the more significant the dissolution increase. Infrared spectrum shows that flunarizine has no chemical interaction with PVP. However, there are exceptions. Some drugs and PVP have the best dissolution effect in a certain proportion. Tantishaiyakul and others found that when the ratio of piroxicam to ∶PVP was1:5 and1:6, the dissolution rate of solid dispersion was the highest, which was 40 times higher than that of single drug within 5 minutes.
Polyvinylpyrrolidone (PVP) can also be dissolved in other molten dropping pills, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer, stearic acid, glyceryl monostearate, etc. To make a composite matrix.
The PVP grade commonly used in the materialized cosmetics industry is K-30. Commercially available PVP is white free-flowing powder or solid, and its content is in the form of aqueous solution with mass fraction of 20%, 30%, 45% and 50%. PVP is soluble in water and has hygroscopicity. Its equilibrium hygroscopicity is about 1/3 of the relative humidity of the environment, which is similar to the hydration of protein. Each monomer is associated with 0.5 mole of water. Polyvinylpyrrolidone (PVP) is not easy to react chemically. Dry PVP is very stable when stored under normal conditions. The mildewproof solution is also stable. When heated to 150℃ in air or mixed with ammonium persulfate and heated at 90℃ for 30 minutes, PVP will be exchanged into water-insoluble compounds. In the presence of oxidant such as azo compound or dichromate, light will change PVP solution into gel. When its solution is heated with strong alkali (such as sodium silicate or trisodium phosphate), precipitation will occur. Many different compounds can form complexes with PVP, for example, the complex formed by PVP and iodine is very stable, has good bactericidal effect and can reduce its toxicity; Adding polyacrylic acid, tannic acid or polymethylvinyl ether and maleic acid into the aqueous solution of polyvinylpyrrolidone PVP will form an insoluble complex, which is insoluble in water, alcohol and ketone, but neutralizing polybasic acid with alkali can reverse the reaction. PVP complexed with toxins, drugs and chemicals can reduce its toxicity. Some dyes can also be strongly complexed with PVP, which is the basis for polyvinylpyrrolidone PVP to be used as dye decolorizer.
As a ketone organic compound, polyvinylpyrrolidone can be used as a clarifier. Stabilizer; Thickening agent; Tablet filler; Dispersant. PVP with molecular weight of 360,000 is often used as a clarifier for beer, vinegar and wine.
The use of polyvinylpyrrolidone In the early 1950s, the older hair styling agent based on shellac and oil was quickly replaced by polyvinylpyrrolidone PVP spray, which is still widely used. It can form a re-wettable transparent film on hair, which has luster and good lubricity. PVP has good compatibility with various propellants and corrosion resistance. It is widely used in hair styling and combing products, as emollients and stabilizers for film formers, skin care lotions and creams, as base materials for eye and face beauty cosmetics and lipsticks, as dispersants in hair dyes and as foam stabilizers for shampoos. PVP can detoxify and reduce the irritation of other preparations to skin and eyes. It is also used as a cleaning agent, gelling agent and antidote in toothpaste. The main disadvantage of polyvinylpyrrolidone PVP is that it is sensitive to moisture, but the influence of moisture and humidity can be alleviated by using its vinyl acetate polymer. In addition, PVP is also widely used in medicine, beverage and textile industries.
The rheology of aqueous solution and methanol is the best solvent for polyvinylpyrrolidone (PVP). The pH value has little effect on the viscosity of PVP aqueous solution. For example, at 25℃, the viscosity of 5% PVP K-30 aqueous solution is 2.3 ~ 2.4 MPa·s； in the range of pH 0. 1 ~ 10; 4.96 MPa sec in concentrated hydrochloric acid. Temperature has little effect on the viscosity of PVP aqueous solution. Non-crosslinked PVP solution has no special thixotropy, only when the concentration is very high, and it shows a short relaxation time. Table 3 below lists the viscosity of polyvinylpyrrolidone PVP K-30 in various solvents.
Viscosity of polyvinylpyrrolidone PVP K-30 in different organic solvents at room temperature
Chart 3: Viscosity of polyvinylpyrrolidone PVP K-30 in various organic solvents (wt%) (room temperature)
References:
Qiu, editor. The Complete Works of Cosmetic Chemistry and Technology, Volume 1. Beijing: China Light Industry Press. 1997。
Compatible polyvinylpyrrolidone is mainly used as pharmaceutical excipient, blood compatilizer, cosmetic thickener, latex stabilizer and beer brewing clarifier.
Whether in solution or in the form of film, polyvinylpyrrolidone PVP has high compatibility, which can be compatible with most inorganic salt solutions, many natural and synthetic resins and other chemicals. Examples of their compatibility are shown in Figures 4 and 5.
Compatibility of polyvinylpyrrolidone PVP with some substances in water or ethanol
Chart 4: Compatibility of polyvinylpyrrolidone PVP with some substances in water or ethanol.
Solubility and compatibility of polyvinylpyrrolidone PVP in different solvents
Figure 5: Solubility and compatibility of polyvinylpyrrolidone PVP in different solvents
Safe PVP is physiologically inert. Acute oral toxicity of polyvinylpyrrolidone LD50:100g/kg. It will not irritate skin or eyes, nor will it cause skin allergy. Long-term toxicological studies have confirmed that polyvinylpyrrolidone can be used for intraperitoneal injection, intramuscular injection, intravenous injection and parenteral administration. The results of subacute and chronic toxicity tests were negative.
Discrimination test
Soluble in water, ethanol and chloroform, insoluble in ether. According to OT-42 method.
Dichromate precipitation test In 5ml of 2% sample solution, add 5ml of diluted hydrochloric acid test solution (TS- 1 17), and then add 5ml of water and 2ml 10% potassium dichromate solution. An orange precipitate should form.
Dissolve 75 mg of cobalt nitrate and 300 mg of ammonium thiocyanate in 2 ml of water, add 5 ml of 2% sample aqueous solution, mix and acidify with dilute hydrochloric acid solution (TS- 1 17). A light blue precipitate should form.
Take 5ml of 2% sample solution, add 5ml of 25% hydrochloric acid, 5ml of 5% barium chloride solution and1ml of 5% molybdotungstate phosphate solution to produce a large number of white precipitates, which will gradually turn blue in the sun.
The pH value of 5% sample solution should be 3.0 ~ 3.7. According to the conventional method.
Add a few drops of iodine test solution (TS- 124) to 5ml of 0.5% test solution. It should produce a deep red color.
In the identification test, take 1g sample, add water to 10ml to make suspension, add 0. 1ml iodine test solution (TS- 124), and after mixing and shaking for 30s, the iodine test solution should fade (to distinguish it from polyvinylpyrrolidone, it can form red). Add starch test solution (TS-235) 1ml, shake well, and there should be no blue color.
The content analysis is based on the nitrogen content obtained from the following quality index analysis.
toxicity
Allowable daily intake is 0~50 (FAO/WHO, 200 1)
LD50 & gt； 100g/kg (rats, orally).
It can be safely used in food (FDA, 173.55, 2000).
toxicity
ADI has no special regulations (FAO/WHO, 200 1).
It can be used safely in food (FDA,121.110,173.50,2000).
LD50 12g/kg (mice, intraperitoneal injection).
Usage limit GB 2760- 1996: GMP for beer.
Crosslinked homopolymer of chemically pure vinyl pyrrolidone. Free-flowing white or nearly white powder with certain hygroscopicity. It has a slight smell. Drugs are insoluble in water and all common solvents such as ethanol and ether, so it is impossible to determine the range of molecular fish. However, it has the same ability to complex with various substances (such as various sugars that cause discoloration of drinks such as wine) as polyvinylpyrrolidone (PVP). And is easy to remove after filtration due to its insolubility.
Use clarifier; Pigment stabilizer; Colloidal stabilizer. It is mainly used for the clarification and quality stabilization of beer (the reference dosage is 8 ~ 20g/ 100 L, which can be removed by filtration after 24 hours), and can also be used in combination with enzyme (protease) and protein adsorbent. It is also used as a stabilizer for clarifying wine and preventing discoloration (reference dosage is 24 ~ 72g/ 100l).
Use clarifier; Stabilizer; Thickening agent; Tablet filler; Dispersant. PVP with molecular weight of 360,000 is often used as a clarifier for beer, vinegar and wine.
Used as stationary liquid for gas chromatography
It is widely used as thickener, emulsifier, lubricant and clarifier, and also as a compound of disinfectant PVP-I.
Used as colloid stabilizer and clarifier, can be used to clarify beer, and can be used appropriately according to production needs.
Disinfectants are used in medical treatment, aquaculture and animal husbandry. Used for disinfection of skin and mucosa.
PolyFilterTM molecules with amide bonds are used to adsorb hydroxyl groups on polyphenol molecules to form hydrogen bonds. Therefore, it can be used as a stabilizer for beer, fruit wine/wine and beverage wine to prolong its shelf life and improve its transparency, color and taste. Products are available in disposable and renewable specifications, and disposable products are suitable for small and medium-sized enterprises. Recycled products need to buy special filtration equipment, but they can be recycled, which is suitable for recycling in large breweries.
In the use of daily cosmetics, PVP and * * * polymer have good dispersibility and film-forming properties, and can be used as styling liquid, styling agent for hair gel and mousse, shading agent for hair care agent, foam stabilizer for shampoo, wave styling agent and dispersant and affinity agent in hair dye. Adding PVP to cream, sunscreen and depilatory can enhance the wetting and lubricating effect. Using PVP's excellent surface activity, film-forming, no irritation to skin and no allergic reaction, it has broad prospects in hair care products and skin care products.
Uses: Used to adsorb phenols and tannins in water extract and purify plant enzymes. Used as chromatographic adsorbent to separate aromatic acids, aldehydes and phenols. Used for clarification of beer and wine.
The production method is as follows: N- vinyl -2- pyrrolidone is polymerized and crosslinked in the presence of alkaline catalyst or N, N'- divinamidine to obtain a crude product, and water, 5% acetic acid and 50% ethanol are used for reflux until the extract is less than or equal to ≤50mg/kg.
The production method is that the purified 1- ethylene -2- pyrrolidone 30% ~ 60% aqueous solution is crosslinked and homopolymerized at 50℃ in the presence of ammonia or amine with hydrogen peroxide as catalyst.
The production method comprises the following steps: polymerizing and crosslinking N- vinyl -2- pyrrolidone in the presence of an alkaline catalyst or N, N'- divinylimidazole to obtain a crude product, and refluxing with water, 5% acetic acid and 50% ethanol until the extract is less than or equal to ≤50mg/kg (about 3h or more).
Safety/security information
Safety instructions 22-24/25
Germany WGK 1
RTECS number TR8370000
The spontaneous combustion temperature is 440℃
TSCA yes
Customs code 39059990
Toxic Material Data 9003-39-8 (Hazardous Material Data)
Toxicity of oral LD50 in rabbits: > 2000mg/kg.
MSDS information
Language: English supplier: polyvinylpyrrolidone
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Price of polyvinylpyrrolidone (reagent grade)
Updated on 2022- 1 1-07.
Product number A 143 15
Product name: polyvinylpyrrolidone with an average molecular weight of 58,000.
CASNo. 9003-39-8
Packaging 100g
Price 450
Updated on 2022- 1 1-07.
Product number A 143 15
Product name: polyvinylpyrrolidone with an average molecular weight of 58,000.
CASNo. 9003-39-8
Packaging 500g
Price 14 19
Upstream and downstream product information of polyvinylpyrrolidone
Upstream raw material ethanolamine 1, 3- butadiene 1, 4- butanediol N- vinylpyrrolidone.
There are more suppliers of polyvinylpyrrolidone
Company name: Shanghai Chengyu Biotechnology Co., Ltd. Gold Products
Tel:+86-021-5152505513818175442.
Product introduction: Chinese name: povidone; polyvinylpyrrolidone
English name: PovidonePVP polyvinylpyrrolidone
CAS number: 9003-39-8
Purity: USP/BP/EP/TECH/COSMETIC Packing information: 25KG Note: 1
Company Name: Hefei Tian Jian Chemical Co., Ltd. Gold Products
Tel: 551-6541867915837135945.
Product description: Chinese name: polyvinylpyrrolidone
English name: polyvinylpyrrolidone
CAS number: 9003-39-8
Purity: 99% Minimum packing information: 25kg/ barrel Remarks: manufacturing
Company name: Shanghai Aladdin Biochemical Technology Co., Ltd. Gold Products
Tel: 400-62063333-115601730970.
Product description: Chinese name: polyvinylpyrrolidone
English name: polyvinylpyrrolidone
CAS number: 9003-39-8
Package information: 899. 1RMB/2.5KG Note: The average molecular weight of reagent grade is 58,000, K29-32.
Company name: Beijing Merida Gold Products Technology Co., Ltd.
Tel: 0 10-82387566
Product description: Chinese name: polyvinylpyrrolidone
CAS number: 9003-39-8
Purity: 8000, K 16- 18 packing information: 100g Remarks: average molecular weight: 8000, K 16- 18 8g.
Company name: Jiangsu Ai Kang Biomedical R&D Co., Ltd. Gold Products
Tel: 025-58859352 18068836627
Product description: English name: polyvinylpyrrolidone
CAS number: 9003-39-8
Purity: 95% HPLC or GC packing information: 10G, 5g; 1G
The price of polyvinylpyrrolidone
65438+Latest price of polyvinylpyrrolidone on February 6th.
65438+February 6th Latest offer of polyvinylpyrrolidone manufacturer: 78 yuan/kg.
2022- 12-07 08:35:05
The latest price of polyvinylpyrrolidone on February 4th is 65438.
65438+February 4th The latest offer of polyvinylpyrrolidone manufacturer: 78 yuan/kg.
2022- 12-05 08:33:32
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Sodium lauryl polyoxyethylene ether sulfate ethylenediamine platinum chloride 1, 1, 3,3-tetramethylbutyl isocyanate silver tert-butyl isocyanate ethyl isocyanate chromium salt aluminum triacetate isocyanate methyl tri (2,2,6,6-tetramethyl-3,5-heptanedioic acid) acetylacetone europium copper bissalicylamide ethyl cobalt povidone iodine poly.
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