Domagk/KLOC-0 was born in Lago, Brandenburg, Germany on October 30th, 1895.
In the late 1920s, Domagk, who was bent on playing a role in the pharmaceutical industry, entered the industry and worked for a large German dye company, I.G. Dye Industry Company. The reason why Domagk joined I.G. Dyestuff Industry Company is not that he changed his ambition. His purpose is to use the company's superior scientific research conditions to find new drugs from dyes.
It is not impossible to find drugs from dyes. At that time, people had not found the law of the relationship between drug molecular structure and efficacy, and could not effectively synthesize new chemical drugs. Therefore, people can only use the "screening method" to find new drugs, that is, screening various compounds one by one to determine whether they have curative effects. Dyes are mostly compounds, so testing whether dyes can be used as drugs was considered as one of the ways to find new drugs at that time. Because of this, Domagk came to I.G. Dye Industry Company and led a laboratory of the company to do drug screening.
Screening new drugs by "screening method" is a heavy workload and low efficiency, and it is impossible to do this work well without a certain will and perseverance. Since Ehrlich, a German bacteriologist, obtained a new drug 606 for the effective treatment of syphilis pathogens in 1907 by screening arsenic-containing organic compounds one by one, and started chemotherapy, many chemists and pharmacologists followed in his footsteps and tried to find ideal and effective antibacterial drugs through experiments. After more than 20 years, their sweat has merged into a small river, but it has little effect. They only found several drugs to treat malaria, such as adipine and malaquine. Now, Domagk has also become a member of this drug-seeking team.
Just as they were having trouble finding new drugs in Domagk, an unexpected opportunity appeared before them. At that time, there was a newly synthesized dye, and its commercial name was "Bailang Duoxi", which was a very beautiful orange-red compound. The sales prospect of this dye in the market is very promising.
1932 One day, Domagk came to the laboratory and found this orange dye. I asked my colleagues, only to know that this is the company's new "hundred waves and more interest". So, does this new dye have medical value? He decided to give it a try.
Colleagues advised him not to waste time because they had already done the experiment and the result was qualitative. Domagk didn't listen to his colleagues' advice, and his intuition told him that it was not that simple to have fun. He picked up a test tube, filled it with all kinds of bacteria in turn-Staphylococcus, Escherichia coli, Streptococcus ... and then dropped it into the tube respectively, and then observed its sterilization effect.
As my colleague said, hundreds of waves and many breaths can't kill any bacteria.
Is there something wrong with your intuition? Is it really of no medical value? Give up or continue? At this moment, he once again remembered ehrlich's famous saying that dyes can be the basis of treatment. He decided to break away from convention, skip the test tube and do experiments directly with animals.
Colleagues disagreed with Domagk's decision. What drugs can kill bacteria in the body without killing bacteria in vitro? But they couldn't beat Domagk, so they had to let him go. Just this Christmas, a miracle happened. Domagk injected this orange dye into two mice infected with Streptococcus. The two mice had been fatally infected and would die, but they miraculously survived after being injected with Brandoxi. Repeated experiments confirmed the same conclusion: Brando was able to subdue Streptococcus. In this way, Domagk discovered a new drug which can effectively inhibit bacteria.
Domagk was very happy when he discovered the medical value of Blanchard. The experiment on mice was very successful, so he decided to analyze and improve the chemical structure of Bailangduoxi to improve its curative effect, and on the other hand, to expand the scope of the experiment and further verify its curative effect.
1933 One day, his little daughter Ai Lisha suddenly fell ill.
Ai Lisha is the apple of his eye and is very popular with him. The reason for Ai Lisha's illness this time is very simple. He accidentally pricked his hand with a needle while playing. Domagk didn't take this seriously at first, but the next day, her daughter's hand was swollen. He rushed his daughter to the hospital for treatment. After examination, my daughter's hand was infected with streptococcus.
Hearing the news, Domagk was frightened to disgrace. He knew that the specific medicine for treating this infection had not yet come out, and even the word specific medicine had not yet appeared. Together with the doctor, he tried his best to treat her, but instead of getting better, his daughter's condition got worse every day, and death was approaching her.
In the face of her daughter's deteriorating condition, Domagk asked herself more than once: Do you want to give her a try with Brando? You know, this medicine has not been clinically tested, and he is not sure whether it is suitable for the human body, so he dare not take the risk. However, his daughter's illness no longer made him hesitate. If he doesn't try, he will surely die. If you try, you may still be saved. In this way, the clinical trial of Bai Lang Duo Xi was carried out ahead of schedule as a last resort.
The experiment began. Domagk watched nervously as a large dose of Blanchard was slowly injected into her daughter through a syringe. He was so nervous that he stayed by his daughter's side, observing the reaction and unwilling to leave for a moment. Miracle appeared again, my daughter's fever was gone, people began to wake up, and gradually got the spirit and could eat. It didn't take long to recover.
Domagk cured her daughter with hundreds of waves and many breaths. The story was widely circulated and soon spread all over London and the world. Soon, news came from the other side of the Atlantic that it would take hundreds of waves and many breaths to build great achievements again. It turned out that the son of American President Roosevelt was ill in bed with a high fever because of bacterial infection. The doctors tried their best, but they couldn't control the development of the disease. Mr. and Mrs. Roosevelt are very worried about this. Later, the doctor suggested trying a new drug, Bai Lang Duo Xi, which was shipped from England. This proposal was approved by Roosevelt. As a result of the test, Roosevelt turned the corner and was discharged soon. When this happened, people were even more impressed and interested. For a time, Brando was famous and popular all over the world. In this way, a new effective fungicide-sulfanilamide was finally born in the world. This is the origin of sulfonamides.