Let's just say that the genetic engineering of hepatitis B vaccine is to cut the plasmid (RNA) containing hepatitis B virus coat (surface antigen) gene through genetic engineering, and then transport it to the corresponding host (such as yeast and CHO cells), and then recombine with the gene in the host cell to make the recombinant yeast or CHO cells produce hepatitis B virus coat (surface antigen), and then purify, prepare and inoculate the human body. Genetically modified soybeans or something, the same principle. Therefore, if the host cell is yeast, then its vaccine is recombinant yeast hepatitis B vaccine; If the host is CHO cells, then its vaccine is recombinant CHO hepatitis B vaccine.
So the two factors in your question are only subordinate to each other. Recombinant yeast is a method to prepare hepatitis B vaccine through genetic engineering.
In addition, I will tell you some traditional methods of preparing hepatitis B vaccine.
The traditional method is to extract hepatitis B virus from the blood of hepatitis B virus carriers, and then prepare it through strict procedures such as purification and inactivation, that is, blood-borne vaccine, which has been eliminated due to reasons such as safety, source and cost (such as suspected blood-borne diseases, waste of a lot of plasma, high cost, etc.).
Expand more, which is better, recombinant yeast hepatitis B vaccine or recombinant CHO hepatitis B vaccine? I don't know. You can also search some professional documents online.
Here I can only use my existing knowledge to infer:
First of all, it is certain that there is little difference between the two vaccines.
Second, the host category gap.
Yeast is generally yeast, and there are many kinds of yeast. At present, beer yeast and Hansen yeast are used to produce hepatitis B vaccine. In any case, yeast belongs to the microbial community.
CHO cell is the ovary of China hamster, which is an animal tissue cell.
Both recombinant yeast and recombinant CHO cells produce hepatitis B virus surface antigen and other things at the same time.
In terms of host affinity, CHO cells are definitely closer to the human body. Of course, after all, we are inoculated with the hepatitis B virus surface antigen produced by it, which is a hepatitis B vaccine prepared after strict process purification, not the host, so it doesn't matter much.
Without participating in any authoritative professional literature, if you have to care, I suggest choosing recombinant CHO hepatitis B vaccine.
Once again, the above is an inference made by individuals at their current level without referring to any relevant authoritative literature. Doesn't represent reality. Please also participate in professional authoritative literature.